A5035952998- Plant Stress Responses and Tolerance
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Plant responses to water stress
- Toxic Organic Pollutants Impact
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Microplastics and Plastic Pollution
- Kruppel-like factors research
- Immune cells in cancer
- biodegradable polymer synthesis and properties
- Microbial bioremediation and biosurfactants
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Nanoparticles: synthesis and applications
- RNA Research and Splicing
- Cerebrovascular and Carotid Artery Diseases
- Plant nutrient uptake and metabolism
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- Plant Molecular Biology Research
- RNA regulation and disease
Nanjing Agricultural University
2016-2025
University of California, Davis
2014-2023
Hebei Agricultural University
2023
Shanghai First People's Hospital
2021-2023
Shanghai Jiao Tong University
2023
University of California Davis Medical Center
2009-2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
BioScience Laboratories (United States)
2023
Nanjing University of Science and Technology
2019-2021
MicroRNAs (miRNAs) regulate gene expression and have a critical role in many biologic pathologic processes. We hypothesized that miRNA profiles injured brain (hippocampus) would show common as well unique when compared with those of blood. Adult, untouched, control rats were sham surgeries, ischemic strokes, hemorrhage (lysed blood, fresh or thrombin), kainate-induced seizures. Brain whole-blood assessed 24 h later using TaqMan rodent arrays. MicroRNA response different for each condition....
We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Escherichia coli bacteria can form extracellular amyloid and have been reported as the predominant found in normal human brains.Brain samples from gray white matter were studied patients AD (n = 24) age-matched controls 18). Lipopolysaccharide (LPS) E K99 pili protein evaluated by Western blots immunocytochemistry. Human brain assessed for...
Nanoscale plastic particles are widely found in the terrestrial environment and being increasingly studied recent years. However, knowledge of their translocation accumulation mechanism controlled by nanoplastic characterizations plant tissues is limited, especially cells. Here, 20 mg L–1 polystyrene nanoparticles (PS NPs) with different sizes amino/carboxy groups were employed to investigate internalization process wheat roots From results, we that uptake small-size PS NPs root was...
microRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell expression present. this study sought to determine the miRNA differentially expressed peripheral blood cells acute and thus may regulate expression.miRNA from forty-eight vascular risk factor controls were compared. Differentially determined by microarray qRT-PCR confirmation. The targets pathways associated be regulated identified...
A blood-based biomarker of acute ischemic stroke would be significant value in clinical practice. This study aimed to (1) replicate a larger cohort our previous using gene expression profiling predict stroke; and (2) refine prediction by including control groups relevant stroke.Patients with (n=70, 199 samples) were compared subjects who healthy (n=38), had vascular risk factors (n=52), myocardial infarction (n=17). Whole blood was drawn ≤3 hours, 5 24 hours after onset from subjects. RNA...
Background and Purpose— Although peripheral blood mRNA micro-RNA change after ischemic stroke, any role for long noncoding RNA (lncRNA), which comprise most of the genome have been implicated in various diseases, is unknown. Thus, we hypothesized that lncRNA expression also changes stroke. Methods— was assessed 266 whole-blood samples drawn once per individual from patients with stroke matched vascular risk factor controls. Differential by ANCOVA ( P <0.005; fold change>|1.2|),...
Abstract Objective: The cause of stroke remains unknown or cryptogenic in many patients. We sought to determine whether gene expression signatures blood can distinguish between cardioembolic and large‐vessel causes stroke, these profiles predict etiology the group. Methods: A total 194 samples from 76 acute ischemic patients were analyzed. RNA was isolated run on Affymetrix U133 Plus2.0 microarrays. Genes that determined at 3, 5, 24 hours following onset. Predictors evaluated using...
Aims Epidemiological studies suggest that sex has a role in the pathogenesis of cardioembolic stroke. Since stroke is vascular disease, identifying sexually dimorphic gene expression changes blood leukocytes can inform on sex-specific risk factors, response and outcome biology. We aimed to examine immune following by studying differential peripheral white cells. Methods Results Blood samples from patients with were obtained at ≤3 hours (prior treatment), 5 24 (after treatment) after onset (n...
Soil management practices, such as tillage method or straw return, could alter soil organic carbon (C) contents. However, the effects of return on C (SOC) have showed inconsistent results in different soil/climate/cropping systems. The Yangtze River Delta China is main production region rice and wheat, rice-wheat rotation most important cropping system this region. few studies been conducted to assess methods combined with labile fractions system. In study, a field experiment was used...
Process of entry for ZnO NP uptake in wheat leaves.
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to improve multiple normal endothelial cell functions and inhibit vascular wall proliferation. We hypothesized that one such agent, simvastatin, would attenuate chronic hypoxic pulmonary hypertension. Male adult Sprague-Dawley rats were exposed (14 days) normoxia (N), plus once-a-day administered simvastatin (20 mg/kg ip) (NS), hypoxia (10% inspired O2 fraction) (H), or (HS). Mean artery pressure,...
Gene expression studies require appropriate normalization methods. One such method uses stably expressed reference genes. Since suitable genes appear to be unique for each tissue, we have identified an optimal set of the most in human blood that can used normalization.Whole-genome Affymetrix Human 2.0 Plus arrays were examined from 526 samples males and females ages 2 78, including control subjects patients with Tourette syndrome, stroke, migraine, muscular dystrophy, autism. The top 100 a...
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are of particular concern due to their hydrophobic, recalcitrant, persistent, potentially carcinogenic, mutagenic and toxic properties, ubiquitous occurrence in the environment. Most PAHs environment present surface soil. Plants grown PAH-contaminated soils or water can become contaminated with because uptake. Therefore, they may threaten human animal health. However, mechanism for uptake by crop roots is little understood. It...
The cause of ischemic stroke remains unclear, or cryptogenic, in as many 35% patients with stroke. Not knowing the restricts optimal implementation prevention therapy and limits research. We demonstrate how gene expression profiles blood can be used conjunction a measure infarct location on neuroimaging to predict probable cryptogenic stroke.The was predicted using previously described differentially expressed genes characteristic cardioembolic, arterial, lacunar RNA isolated from peripheral...
Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and rats following ischemic stroke, we tested whether elevating would improve stroke outcomes rats. Young adult were subjected to a temporary middle cerebral artery occlusion (MCAO) or sham operation. A polyethylene glycol-liposome-based transfection system was used administer mimic after MCAO. Neurological deficits, brain infarction, vessel integrity, adhesion molecule expression target...