A5103154531- Carbon dioxide utilization in catalysis
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- CO2 Reduction Techniques and Catalysts
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Advanced Photocatalysis Techniques
- Asymmetric Hydrogenation and Catalysis
- Inorganic Fluorides and Related Compounds
- Catalytic Cross-Coupling Reactions
- Ionic liquids properties and applications
- Organoboron and organosilicon chemistry
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- HIV Research and Treatment
- Catalysis for Biomass Conversion
- Forest Insect Ecology and Management
- DNA and Nucleic Acid Chemistry
- Insect Resistance and Genetics
Henan Normal University
2015-2025
Ministry of Education
2025
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Tropical Agricultural Sciences
2019-2023
Nankai University
2017-2022
Henan University of Technology
2020-2022
Beijing Institute of Technology
2015-2021
Institute of Organic Chemistry
2020
China University of Petroleum, Beijing
2016
Fuzhou University
2013-2015
Abstract In the last few years, photochemical and electrochemical CO 2 transformations have attracted increasing attention in response to topical interest renewable energy green chemistry. The present minireview offers an overview about current approaches for carbon dioxide fixation with organic compounds. Valuable products, including carboxylic acids heterocyclic compounds, are accessible through carboxylation carboxylative cyclization, respectively. processes, photo‐ or electro‐induced...
This review discusses recent advances in the photocatalytic carboxylation of C(sp<sup>3</sup>)–X (X = H, N) bonds, C(sp<sup>2</sup>)–X N, (pseudo)halide) bonds and C(sp)–H with CO<sub>2</sub>.
The CF3S-substituted moiety serves as an important structural element in many bioactive molecules. A versatile copper catalyst that allowed for trifluoromethylthiolation of primary and secondary α-bromoketones is described. reaction with readily available elemental sulfur CF3SiMe3 afforded a broad scope moderate to good yields α-trifluoromethylthio-substituted ketones. This procedure represents very operationally simple yet powerful strategy the synthesis ketones, useful class synthetic synthons.
A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2 H -indazoles and imidazo[1,2- a ]pyridines (40 examples) using commercially available α-bromoesters was realized in water.
Direct, economical, and green synthesis of deuterated α-amino phosphine oxides remains an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven umpolung strategy for synthesizing from isocyanide using 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene as the photocatalyst D2O deuterium source. Moreover, streamlined sustainable methodology can be applied modification amino acids, natural products, drugs. The strong antiproliferative activity desired products...
Herein, we present an efficient synthesis of 1,7-fused indolines tethered with a spiroindolinonyl moiety through the cascade reaction indolin-1-yl(aryl)methanimines diazo oxindoles. To best our knowledge, this is first example in which indoline skeleton was constructed along simultaneous introduction spiro element initiated by C–H bond activation indoline. In forming title product, substrate and coupling partner demonstrated unprecedented pattern latter acts as C1 synthon to participate...
Presented herein is an atom- and step-economical method enabling the precise assembly of a heptacyclic scaffold containing both azocine indoline units through cascade reactions indolin-1-yl(aryl)methanimines with diazo indanediones. The formation products involves C–H bond activation double carbene insertion followed by intramolecular condensation, retro-[2 + 2] cycloaddition, recyclization. This reaction not only provided concise straightforward strategy for synthesis otherwise difficult to...
The cleavage of C–O bond in lignin β-O-4 model compounds to form aromatics has been achieved via a two-step process, comprising visible-light photocatalytic oxidation and situ carbonic acid-facilitated hydrogenolysis. In the first step, with readily available persulfate as radical initiator cheap copper catalyst, secondary alcohol alkyl-aryl ether linkage is selectively oxidized corresponding ketone up 99% yield under irradiation. second step features ketones promoted by acidic EtOH/H2O/CO2...
Abstract Efficient conversion of CO 2 into fuels and chemicals with solar energy would be promising, but also faces great challenge. In this context, we describe the photoreductive functionalization to construct new C−C, C−N, C−O bonds through respective Pd‐catalyzed Suzuki carbonylation, aminocarbonylation, alkoxycarbonylation aryl iodides in situ generated photoreduction . This protocol opens up an alternative avenue for utilization by harnessing energy.
The greener synthesis of N-substituted isonicotinamides is high importance and remains a significant challenge to the chemistry community. Herein we delineated visible-light-driven, transition-metal-free, external-oxidant-free radical-radical cross-coupling reaction access via consecutive photoinduced electron transfer (ConPET). utility this protocol highlighted through N-terminal modification peptides late-stage drugs.
Abstract An efficient and practical approach to α‐trifluoromethylthio‐substituted ketones was developed. The trifluoromethylthiolation of (bpy)Cu(SCF 3 ) (bpy = 2,2′‐bipyridyl) with various α‐bromo afforded the desired in good yields. reaction tolerates more functionally than previously reported methods demonstrates scalability practicality.
Abstract Highly efficient and selective hydroboration of nitriles carbodiimides with pinacolborane (HBpin) is achieved by using the simple convenient n ‐BuLi as a catalyst. Solvent‐free good functional group tolerance under mild conditions have been achieved. A possible mechanistic pathway catalyzed HBpin proposed.
The inexpensive Keggin‐type polyoxometalate, i.e. H 3 PW 12 O 40 was found to be an effect catalyst for the condensation‐cyclization reaction of 1,2‐phenylenediamines and trifluoromethyl ketones synthesize trifluoromethylated heterocycles, including benzimidazolines, benzoxazolines benzothiazolines. Only 1 mol% required in this work, synergistic proton polyanion vital reaction. Significantly, POM could easily recovered by using a biphasic solvent system (H 2 O/toluene, V/V = 1:5), reused at...
The search and use of diazo surrogates as safer carbene precursors constitute an important task among the synthetic community. Presented herein is a concise robust synthesis indoline fused 1,3‐diazepines via cascade reactions indolin‐1‐yl(aryl)methanimines with pyridotriazoles safe alternative precursors. With this method, 43 diazepine derivatives were prepared in up to 80% yield. Preliminary mechanism studies showed that formation product involves process including C−H bond metallation,...
Bruton's tyrosine kinase (BTK) is a crucial enzyme in the B cell receptor signaling pathway. It plays central role development, maturation, and signaling. This extends to survival, proliferation, migration of malignant cells, making BTK an intriguing target search for therapeutics against malignancies. Our research focused on discovery covalent inhibitor with good selectivity potency favorable safety profile. We identified compound 22, imidazo[1,2-b]pyridazine derivative, exhibiting potent...
β,γ-Alkenyl ketones are privileged structural motifs in organic synthesis with broad pharmaceutical relevance. In this context, we have successfully developed a visible-light-driven radical cross-coupling of α-keto acids vinylcyclopropanes, enabling...
As a bridging molecule for the conversion of CO<sub>2</sub> to CO, formic acid is successfully applied rhodium-catalyzed carbo- and hetero-Pauson–Khand-type reactions, affording moderate high yields bicyclic cyclopentenones.
Abstract A visible‐light‐promoted metal‐free carboxylative cyclization of propargylic amines with CO 2 was shown to offer exo ‐iodomethylene 2‐oxazolidinones. Incorporation both and iodo moieties into these compounds realized efficiently. The mechanism study revealed that this proceeds through a radical pathway. Notably, the iodine‐functionalized 2‐oxazolidinone as platform molecule could be easily converted wide range value‐added chemicals Buchwald–Hartwig, Suzuki, Sonogashira,...
Relatively mild conditions, easy work-up and a simple purification; the stable easily obtained catalyst presented here could be reused for more than 200 cycles 10 cm length of copper wire.