A5000903563- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Heart Failure Treatment and Management
- Monoclonal and Polyclonal Antibodies Research
- Organic Electronics and Photovoltaics
- Frailty in Older Adults
- Cardiac Arrhythmias and Treatments
- Glycosylation and Glycoproteins Research
- Cardiovascular and Diving-Related Complications
- Oxidative Organic Chemistry Reactions
- Stroke Rehabilitation and Recovery
- Cancer Genomics and Diagnostics
- Coordination Chemistry and Organometallics
- Atrial Fibrillation Management and Outcomes
- Cell Adhesion Molecules Research
- Conducting polymers and applications
Sakakibara Hospital
2013-2025
Horiba (Japan)
2023-2024
Tokushima University Hospital
2022-2023
Hiroshima University
2006-2022
Teine Keijinkai Hospital
2019-2021
Nippon Medical School
2016-2019
University of Fukui
2019
Hokkaido University of Science
2019
Asahikawa Medical University
2018
Juntendo University
2018
The actually direct Suzuki–Miyaura coupling with "protected" R–B(dan) (dan = naphthalene-1,8-diaminato) was demonstrated to smoothly occur without in situ deprotection of the B(dan) moiety. use t-BuOK (Ba(OH)2 some cases) as a base under anhydrous conditions is key successful cross-coupling, where readily converted into transmetalation-active borate-form, regardless well-accepted diminished boron-Lewis acidity.
Importance The characteristics and treatment strategies of atrial functional mitral regurgitation (AFMR) are poorly understood. Objective To investigate the prevalence, clinical characteristics, outcomes valve (MV) surgery in AFMR. Design, Setting, Participants This retrospective cohort study, called Real-World Observational Study for Investigating Prevalence Therapeutic Options Atrial Functional Mitral Regurgitation (REVEAL-AFMR), was conducted across 26 Japanese centers (17 university...
The prognostic relevance of plasma volume reduction (PVR) in acute heart failure patients remains unclear because the confounding hemodynamic effect left ventricular ejection fraction impairment on kidney function.Subjects enrolled West Tokyo Heart Failure Registry were examined. PV at admission and discharge was estimated from subjects' body weight its deviation ideal weight. Patients top tertile PVR classified as PVR+. Of 381 with failure, 181 (47.5%) had preserved (HFpEF). Estimated...
Background In patients with sarcoidosis, cardiac involvement is a crucial prognostic factor leading to severe cardiovascular events. Mitral regurgitation (MR) predisposes drug‐refractory heart failure; however, MR in sarcoidosis (CS) has been scarcely investigated and its therapeutic approach remains unclear. This study aimed investigate the clinical impact of transcatheter edge‐to‐edge repair CS. Methods Patients CS‐related ventricular functional were compared those other nonischemic...
Abstract Aims Plasma volume status (PVS) is recognized as a marker of systemic congestion, but its clinical utility in patients with mitral regurgitation (MR) undergoing transcatheter edge‐to‐edge valve repair (M‐TEER) has not been well established. This study aimed to evaluate the prognostic significance PVS these patients. Methods and results Data from 3763 who underwent M‐TEER were analysed Japanese multicentre registry. Patients classified into functional MR (FMR) degenerative (DMR)...
Mineralocorticoid receptor antagonists (MRAs) are integral components of medical therapy for patients with heart failure reduced ejection fraction. However, implication MRA dosing in older undergoing transcatheter edge-to-edge mitral valve repair (TEER) secondary regurgitation remains uncertain. The authors aimed to investigate the prognostic impacts receiving TEER regurgitation. This study included who underwent and were enrolled OCEAN (Optimized CathEter vAlvular iNtervention)-Mitral...
Background The management of mixed aortic valve disease (MAVD), defined as the concomitant presence stenosis (AS) and regurgitation, remains a clinical challenging. present study assessed impact transcatheter replacement (TAVR) on cardiac geometry prognosis in patients with MAVD. Methods Results A retrospective multicenter TAVR registry was conducted, including who underwent for severe symptomatic AS between January 2015 March 2019. Patients were subdivided into 2 groups according to...
During next generation sequencing (NGS) analysis, many missense mutations were found in a well-known oncogene, of which variant uncertain significance mutations. We recently treated an adult patient with pancreatoblastoma by chemotherapy. Using NGS cancer panel, we previously unreported mutation the 1835 codon adenomatous polyposis coli (APC) gene. also heterogeneous APC gene patient's germline Sanger sequencing. Although this did not have history familial polyposis, functional analysis...
// Shigeo Yamaguchi 1 , Shin Takahashi 2 Kaoru Mogushi 3 Yuki Izumi Yumi Nozaki Tadashi Nomizu 4 Yoichiro Kakugawa 5 Takanori Ishida 6 Noriaki Ohuchi Chikashi Ishioka and Shunsuke Kato 1, Department of Clinical Oncology, Juntendo University Graduated School, Tokyo 113-8421, Japan Institute Development, Aging Cancer, Tohoku University, Sendai 980-8575, Diagnostics Therapeutics Intractable Diseases, Disease Research Center, Surgery, Hoshi General Hospital, Fukushima 963-8501, Breast Miyagi...
Although obesity is associated with left ventricular hypertrophy, diastolic dysfunction, and occurrence of atrial fibrillation (AF), obese heart failure (HF) patients have a more favorable clinical outcome (obesity paradox). The impact AF on or lean HF has not been fully elucidated.Methods Results:We analyzed 1,681 who were enrolled in the West Tokyo Heart Failure Registry (WET-HF Registry), multicenter, prospective cohort registry from 2005 through 2014. We assigned them to 3 categories...
The aim of this study was to investigate the use a newly developed micro-computed tomography (micro-CT) system for diagnosis oral pathologies in small animals, using rabbit as model. dental diseases rabbits is usually based on endoscopy and radiographic imaging, but detailed pathological these methods frequently difficult. Micro-CT used address challenge. This conducted 50 privately owned rabbits, presented our hospital due loss appetite or difficulty feeding. Image recording times were 18 s...
A new dimethyl(phenyl)silylborane having a naphthalene-1,8-diaminato (dan) substituent on the boron center, PhMe2Si-B(dan), was synthesized. Owing to diminished Lewis acidity, it is highly stable toward air. Synthetic application of silylborane catalytic silylboration and silylation alkynes also described.
Trisilanylene-bridged oligothiophenes were synthesized, and their vapor-deposited spin-coated films examined as p-type semiconductors in field-effect transistors (FET). Of these, the best FET performance was achieved by using tris[(ethylquinquethiophenyl)dimethylsilyl]methylsilane active material, whose mobility on/off ratio determined to be 6.4 × 10-2 cm2 V-1 s-1 104, respectively. Interestingly, trisilanylene-bridged found photoactive activity of suppressed, when irradiated air (254 nm),...
Non-cardiac surgery for hypertrophic obstructive cardiomyopathy (HOCM) is considered to require meticulous perioperative care. β-blockers are the first-line drugs patients with HOCM, and they play a key role in preventing cardiovascular complications The bisoprolol transdermal patch has recently become available Japan, it useful who unable take oral medication during aim of this case series was assess hemodynamic features HOCM used care non-cardiac surgery.Between August 2016 2018, we...
Background Prognostic implications of transcatheter aortic valve implantation (TAVI) in low‐gradient (LG) stenosis (AS) remain controversial. The authors hypothesized that differences cardiac functional recovery may solve this ongoing controversy. aim was to evaluate clinical outcomes and the response left ventricular (LV) function following TAVI patients with LG AS. Methods Results This multicenter retrospective study included 1742 severe AS undergoing between January 2015 March 2019....
Abstract Aims The aim of this study was to identify phenotypes with potential prognostic significance in aortic stenosis (AS) patients after transcatheter valve replacement (TAVR) through a clustering approach. Methods and results This multi-centre retrospective included 1365 severe AS who underwent TAVR between January 2015 March 2019. Among demographics, laboratory, echocardiography parameters, 20 variables were selected dimension reduction used for unsupervised clustering. Phenotypes...
ABSTRACT Self‐assembled structures from poly(isoprene‐b‐styrene‐b‐2‐vinylpyridine)(ISP)/styrene homopolymer blend were investigated. Five terpolymers whose total molecular weight, M , is in the narrow range of 121k < 214k, and volume fractions center block polystyrenes, ϕ S are similar at around 0.55, prepared as parent terpolymers. Their P / I ratios, used an indicator asymmetry, varied 0.32 2.46. Three low‐molecular weight styrene homopolymers with weights 3k, 9k, 12k, respectively,...