A5103001998- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Lipid metabolism and disorders
- Renal Diseases and Glomerulopathies
- Medicinal plant effects and applications
- RNA modifications and cancer
- Neutropenia and Cancer Infections
- Fungal Biology and Applications
- Medicinal Plants and Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Chronic Kidney Disease and Diabetes
- Immune cells in cancer
- Cholinesterase and Neurodegenerative Diseases
- Hybrid Renewable Energy Systems
- Renal and Vascular Pathologies
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Computational Drug Discovery Methods
- Gout, Hyperuricemia, Uric Acid
Xiamen University
2023-2024
First Affiliated Hospital of Xiamen University
2023-2024
Xiamen Blood Center
2023-2024
Chengdu University of Traditional Chinese Medicine
2014-2022
City University of Hong Kong, Shenzhen Research Institute
2022
University of Hong Kong
2022
Shandong University
2022
Diabetic nephropathy (DN) is one of the most common complications diabetes mellitus and a major cause end-stage kidney disease. Cordyceps sinensis (Cordyceps, Dong Chong Xia Cao) widely applied ingredient for treating patients with DN in China, while molecular mechanisms remain unclear. This study aimed at revealing therapeutic by undertaking network pharmacology analysis. In this study, active ingredients associated target proteins were obtained via Traditional Chinese Medicine Systems...
Background Hyperuricemia is a recognised risk factor for the development of nonalcoholic fatty liver disease (NAFLD). This study aims to investigate therapeutic effect resveratrol (RES) on treatment hyperuricemia-related NAFLD in rats and underlying mechanisms. Methods with hyperuricemia was induced using high-yeast high-fat diet containing potassium oxonate. The impact RES pathology, expression silent information regulator 1 (SIRT1), fork-head box class O-3a (FOXO3a), nuclear kappa B...
Objectives. Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) throughout the world, and identification novel biomarkers via bioinformatics analysis could provide research foundation for future experimental verification large-group cohort in DN models patients. Methods. GSE30528, GSE47183, GSE104948 were downloaded from Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs). The difference gene expression between normal tissues was...
Background Cuproptosis is a novel mode of cell death, which strongly related to energy metabolism in mitochondria and regulated by protein lipoylation. Currently, the molecular mechanisms cuproptosis-related genes (CRGs) involved systemic lupus erythematosus (SLE) largely remained unclear, our study aimed explore cuproptosis CRGs SLE. Methods Bulk RNA-seq datasets were collected display expressions peripheral blood mononuclear cells (PBMCs) SLE healthy individuals, then ROC analysis was used...
Background Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease that lacks reliable diagnostic biomarkers. In our study, we aimed to identify novel biomarker for the diagnosis and activity monitoring of SLE. Methods Bulk RNA scRNA-seq datasets were obtained from Gene Expression Omnibus database. this differential analysis, cell-cell communication algorithm, functional enrichment human protein map database protein-protein interaction analysis immune cell infiltration...
Recurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) an important protein in many biological processes, such as differentiation and development. However, the exact underlying mechanism whereby RARα affects RIF remains unknown. This study investigated expression its contribution mid-luteal phase endometria of patients RIF. The levels CCAAT/enhancer-binding (C/EBP) β normal group were using western blotting...
Potential drug toxicities and interactions of redundant compounds plant complexes may cause unexpected clinical responses or even severe adverse events. On the other hand, super-additivity between natural products synthetic drugs be utilized to gain better performance in disease management. Although without enough datasets for prediction model training, based on SwissSimilarity PubChem platforms, first time, a feasible workflow both toxicity interaction was built this study. The optimal...
In order to establish the quality standard of Berberidis Cortex and improve its control level, water, total ash, acid-insoluble ash alcohol-soluble extract were determined according procedures recorded in Chinese Pharmacopoeia (2010 edition). The qualitative quantitative analyses performed by thin layer chromatography (TLC) high performance liquid (HPLC) methods. results showed that TLC identification had a good resolution with clear spots. water content was 8.39%-12.23%; 4.50%-9.96%;...
Gram-negative bacteremia (GNB) is a common complication in malignant patients. Identifying risk factors and developing prognostic model for GNB might improve the survival rate. In this observational real-world study, we retrospectively analyzed outcomes of Multivariable regression was used to identify incidence GNB, while Cox analysis performed significant factors. A constructed based on presented nomogram. ROC curves, calibration plots, Kaplan-Meier were estimate model. It comprised 1004...
Preterm birth is the leading cause of neonatal death, and there are no effective clinical means for prevention treatment spontaneous preterm birth, mainly because mechanism labor initiation has not been fully elucidated. The effect enucleation with Zhuyun I Recipe Capsule enema (ZRC) on maternal-fetal interface microenvironment in SD rats kidney deficiency blood stasis. In this study, poor endometrial tolerance was induced by hydroxyurea epinephrine stasis type endometrium, gavage...