A5101813922- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Platelet Disorders and Treatments
- Frailty in Older Adults
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Management of metastatic bone disease
- Nutrition and Health in Aging
- Bacterial Identification and Susceptibility Testing
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- RNA and protein synthesis mechanisms
- Generative Adversarial Networks and Image Synthesis
- Lung Cancer Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hepatitis B Virus Studies
- Thermal Regulation in Medicine
- Kruppel-like factors research
Sichuan Cancer Hospital
2021-2025
University of Electronic Science and Technology of China
2021-2025
North Sichuan Medical University
2022
National University of Defense Technology
2016
The current prognostic tools for esophageal squamous cell carcinoma (ESCC) lack the necessary accuracy to facilitate individualized patient management strategies. To address this issue, study was conducted develop a machine learning (ML) prediction model ESCC patients' survival management. Six ML approaches, including Rpart, Elastic Net, GBM, Random Forest, GLMboost, and learning-extended CoxPH method, were employed risk models. trained on dataset of 1954 patients with 27 clinical features...
This single-arm phase 2 trial (ChiCTR2100046715) examined previously untreated patients with advanced esophageal squamous cell carcinoma (ESCC) who received four cycles of paclitaxel carboplatin every 3 weeks. Toripalimab was infused intravenously weeks for 12 months, or until disease progression intolerable toxicity. Radiotherapy that encompassed the primary lesions and metastases commenced in third cycle. The median progression-free survival time 9.8 months (95% confidence interval [CI]:...
Abstract Background Isothermal amplification is considered to be one of the most promising tools for point-of-care testing molecular diagnosis. However, its clinical application severely hindered by nonspecific amplification. Thus, it important investigate exact mechanism and develop a high-specific isothermal assay. Methods Four sets primer pairs were incubated with Bst DNA polymerase produce Gel electrophoresis, sequencing, sequence function analysis used product generation, which was...
Objective. To investigate the expression of Yin-Yang-1 (YY1) in esophageal carcinoma (ESCA) and its effect on glutamine metabolism ESCA. Methods. The roles YY1 ESCA were investigated using a series bioinformatics databases tools. between tissues with corresponding adjacent was validated real-time PCR, western blot, immunohistochemical staining method. Furthermore, effects ESCC cell proliferation migration examined. correlation evaluated by blot. Results. gene highly conserved evolution...
RNA-binding proteins (RBPs) are widely involved in the transcriptional and posttranscriptional regulation of multiple biological processes. The regulatory ability RBPs was indicated by identification chromatin-enriched (Che-RBPs). One these proteins, KH-type splicing protein (KHSRP), is a multifunctional RBP that has been implicated mRNA decay, alternative splicing, miRNA biogenesis plays an essential role myeloid differentiation facilitating maturation miR-129. In this study, we revealed...
Esophageal cancer is a kind of with high morbidity and mortality, which accompanied by profound poor prognosis. A prognostic nutritional index, based on serum albumin levels peripheral lymphocyte count, has been confirmed to be significantly associated various cancers. This study was aimed at exploring the significance PNI in overall survival prognosis patients esophageal cancer. As real-world big database, clinical data 2661 were evaluated retrospectively, individuals randomly divided into...
Abstract Objectives This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase type M and B (CK-MB) total (CK) ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods was a single-center retrospective cohort analysis. Subjects were stage I-III CRC hospitalized Sichuan Cancer Hospital from January 2017 May 2021. Patients divided into abnormal group normal according whether CK-MB/CK surgery. Through comparative analysis clinical...
Abstract Background This study aimed at exploring the correlation between T‐cadherin and programmed death‐ligand 1 (PD‐L1), as well their prognostic value in patients with human papillomavirus (HPV)‐negative head neck squamous cell carcinoma (HNSCC). Methods Immunohistochemical staining was used to identify protein expression of PD‐L1. Spearman linear analysis determine association. Kaplan–Meier utilized plot overall survival (OS) disease‐free (DFS) curves. Cox proportional hazards...
T-cadherin functions as a suppressor gene, which is frequently inactivated by aberrant promoter methylation in several human cancers, but its status oral squamous cell carcinoma (OSCC) has been scarcely studied.Thus this study aimed at exploring the clinical significance and prognostic value of sera patients with OSCC.Methylation-specific PCR (MSP) bisulfate sequencing (BSP) was performed to examine T-cadherin.Then, associations between various clinicopathological variables or patient...
Original scientific
Given the significant therapeutic efficacy of anti-HER-2 treatment, HER-2 status is a crucial piece information that must be obtained in breast cancer patients. Currently, as per guidelines, typically acquired from tissue However, there growing interest obtaining serum and other samples due to convenience potential for dynamic monitoring. In this study, we have developed Raman spectroscopy technique allows rapid acquisition convenient manner. The established negative positive classification...
Abstract Background It has been widely reported that the prognostic nutritional index (PNI) played a pivotal role in assessment of surgical patients and tumor prognosis. In order to improve accuracy evaluation Western China, we established reference intervals (RIs) PNI healthy controls. Methods A retrospective cohort study on ethnic Han adults (18–79 years) was conducted explore influences age, gender, centers, instruments establish RIs. The data came from routine examination center database...
Abstract Background The effectiveness of chemo-immunotherapy for advanced esophageal squamous cell carcinoma (ESCC) remains limited. Therefore, we evaluated the safety and efficacy radiotherapy plus as a first-line therapy ESCC. Methods In this single-arm clinical trial, individuals aged 18–75 years with previously untreated stage IV ESCC received chemotherapy comprising four cycles 135–175 mg/m 2 paclitaxel carboplatin every three weeks. Toripalimab (240 mg) was intravenously infused weeks...
Abstract Platelets are vital in many pathophysiological processes, yet there is a lack of comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, knowledge base aimed at enhancing the understanding and study platelets related diseases. Our team retrieved information from various public databases, extracting analyzing RNA-seq data 3,711 samples across 41 different conditions available on NCBI. PlateletBase offers six analytical...
Gram-negative bacteremia (GNB) is a common complication in malignant patients. Identifying risk factors and developing prognostic model for GNB might improve the survival rate. In this observational real-world study, we retrospectively analyzed outcomes of Multivariable regression was used to identify incidence GNB, while Cox analysis performed significant factors. A constructed based on presented nomogram. ROC curves, calibration plots, Kaplan-Meier were estimate model. It comprised 1004...
Vaccination is effective to prevent hepatitis B virus (HBV) infection. However, there still a risk of infection after vaccination. In clinical work, we found that newborns were positive for HBV surface antigen (HBsAg) vaccination.To determine the effect vaccination on detection HBsAg trend in newborns.We collected data at birth, history B, quantitative results, and other information about born our hospital from July 2017 2020. Serum samples healthy neonates randomly selected be supplemented...
Abstract Objectives: The purpose of this study was to evaluate the prognostic significance Creatine Kinase (CK)-MB total-CK ratio (CK-MB/CK) in patients with stage I-III colorectal cancer (CRC) after radical resection. Methods: This a single-center retrospective cohort analysis. Subjects were CRC hospitalized Sichuan Cancer Hospital from January 2017 May 2021, who underwent curative overall survival (OS), disease-free rate (DFS), and recurrence analyzed between two groups according serum...
<title>Abstract</title> Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: was a single-center retrospective cohort analysis. Subjects were stage I-III CRC hospitalized Sichuan Cancer Hospital from January 2017 May 2021. The overall survival (OS) and disease-free rate (DFS) analyzed between two groups according serum CK-MB/CK levels...
Purpose In patients with resectable esophageal squamous cell carcinoma (ESCC), neoadjuvant therapy increased the curative resection rate, disease-free survival, and overall survival for ESCC. However, efficacy of varies among different patients. We aim to compare differences in characteristics peripheral blood T lymphocyte subsets before after efficacy. Method This study enrolled 266 ESCC who received esophagectomy from August 2018 2022. The postoperative pathological results divided into...
Background: Esophageal squamous cell cancer (ESCC) was a disease with male predominance. Accordingly, the applicability of prognostic indicators values previously set for general population ESCC have not been reported determining physical state in female.Methods: A total 2660 patients were pooled this study. We analyzed clinicopathologic features and clinical predictors to determine associations outcome by sex. also evaluated relationship between cholesterol overall survival (OS) further...