A5037531631- Muscle Physiology and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition and Health in Aging
- Rheumatoid Arthritis Research and Therapies
- Body Composition Measurement Techniques
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Hematological disorders and diagnostics
- Systemic Sclerosis and Related Diseases
- T-cell and Retrovirus Studies
- Vagus Nerve Stimulation Research
- Musculoskeletal Disorders and Rehabilitation
- Medical research and treatments
- Congenital Anomalies and Fetal Surgery
- GDF15 and Related Biomarkers
- Musculoskeletal synovial abnormalities and treatments
- Salivary Gland Disorders and Functions
- Traditional Chinese Medicine Studies
- Parasitic infections in humans and animals
- Exercise and Physiological Responses
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- HER2/EGFR in Cancer Research
Hospital de Clínicas de Porto Alegre
2019-2024
Universidade Federal do Rio Grande do Sul
2019-2024
Thales (United Kingdom)
2019
Abstract Morphometry of striated muscle fibres is critical for monitoring health and function. Here, we evaluated functional parameters skeletal cardiac in two experimental models using the Morphometric Analysis Muscle Fibre tool (MusMA). The collagen‐induced arthritis model was used to evaluate function non‐alcoholic fatty liver disease analysis. After euthanasia, haeamatoxylin eosin stained sections perform fibre segmentation morphometric analysis classified into six subpopulations:...
Abstract Introduction/objectives Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because the poor understanding signaling pathways involved SLE wasting, aim this study was to evaluate effects vitamin D supplementation on mice with pristane-induced lupus. Methods Balb/c lupus-like disease induced by pristane injection were randomized into three groups: (PIL; n = 10), + (PIL VD; 10) and healthy controls (CO; 8). Physical function...
Abstract Background Sarcopenia is a muscle disease characterized by reduction of strength and mass. In RA, 25.9 to 43.3% the patients present sarcopenia. The loss mass observed in RA occurs either activation catabolic pathways or inhibition anabolic pathways. Despite having list drugs capable treating inflammation, their effect on unclear. Our objective was evaluate tofacitinib collagen-induced arthritis (CIA) mice. Methods CIA induced male DBA/1J mice subcutaneous injection Type 2 Collagen...
Abstract Background Rheumatoid arthritis is an autoimmune inflammatory disease that often leads patients to muscle impairment and physical disability. This study aimed evaluate changes in the activity of proteasome system skeletal muscles mice with collagen-induced (CIA) treated etanercept or methotrexate. Methods Male DBA1/J were divided into four groups (n = 8 each): CIA-Vehicle (treated saline), CIA-ETN etanercept, 5.5 mg/kg), CIA-MTX methotrexate, 35 mg/kg) CO (healthy control group)....
<h3>Background</h3> Myokines, such as the growth differentiation factor (GDF) 8 and 11, have function of regulating autocrine paracrine activities on muscle tissue metabolism. In Rheumatoid Arthritis (RA), there is increased expression GDF-8 in synovial membrane compared to osteoarthritis (OA) patients, more specifically by fibroblast-like synoviocytes (FLS). On other hand, GDF-11 treatment appears a protective effect against development experimental arthritis. Therefore, studies evaluating...
<h3>Background</h3> Sarcopenia is a muscle disease characterized by reduction of strength and mass. In RA, 25.9 to 43.3% the patients present sarcopenia [1]. The loss mass observed in RA occurs either activation catabolic pathways or inhibition anabolic [2]. Despite having list drugs capable treating inflammation, effect these therapeutic interventions on are not elucidated [3]. <h3>Objectives</h3> To evaluate tofacitinib collagen-induced arthritis (CIA) mice. <h3>Methods</h3> CIA was...
BACKGROUNDMyokines, such as the growth differentiation factor (GDF) 8 and 11, regulate autocrine paracrine activities on muscle tissue metabolism.In Rheumatoid Arthritis (RA), there is increased expression of GDF8 in synovial membrane, specifically by fibroblastlike synoviocytes (FLS).On other hand, GDF-11 treatment appears to have a protective effect against development experimental arthritis.Therefore, more studies evaluating these myokines' serum levels RA patients are needed define their...
<h3>Background:</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality and associated with metabolic disorders including dyslipidaemia, insulin resistance cachexia. Since the metabolomic profile known to vary in response different conditions, metabolome analysis could substantially contribute diagnosis prognosis. <h3>Objectives:</h3> To analyse urine assess its correlation body composition parameters activity of RA patients. <h3>Methods:</h3>...
Muscle quality in rheumatoid arthritis (RA) is a new concept that involves morphological features and function. A measurement associates cell morphology with clinical physical parameters has not been reported the literature. CIA RA mice model characterized by loss of muscle mass similar to human RA, thereby it convenient study disease impact physiology. Our main goal was develop an index measure morphometry fibers correlate functional performance CIA.
Background: Cystatins are cysteine proteases-inhibitors secreted by Fasciola hepatica in order to modulate the host immune response promote survival of parasite. These molecules able inhibit different mammal cathepsins, regulate balance via Th2 and T regulatory responses, downregulate antigen presentation release pro-inflammatory cytokines (1,2) – mechanisms that important development maintenance several immunopathology, as rheumatoid arthritis (RA) (3). Objectives: To evaluate therapeutic...
Background: Muscle quality in rheumatoid arthritis (RA) is a new concept that involves morphological features and function. A measurement associates cell morphology with clinical physical parameters has not been reported the literature. CIA RA mice model characterized by loss of muscle mass similar to human RA, thereby it convenient study disease impact physiology. Objectives: Develop an index measure morphometry fibers correlate functional performance CIA. Methods: 18 DBA/1J were induced...
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that may affect the joints skeletal muscle system.The growth differentiation factors (GDF)-8 11 have play important role in homeostasis this study aimed to evaluate expression of proteins GDF-8 throughout development collagen induced (CIA).