A5012524854- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Osteoarthritis Treatment and Mechanisms
- Adrenal Hormones and Disorders
- Orthopaedic implants and arthroplasty
- Rheumatoid Arthritis Research and Therapies
- Ocular Infections and Treatments
- Adipose Tissue and Metabolism
- Protist diversity and phylogeny
- Bone and Joint Diseases
- Microbial Community Ecology and Physiology
- Muscle Physiology and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Science and Education Research
- Exercise and Physiological Responses
- Autoimmune and Inflammatory Disorders Research
- Knee injuries and reconstruction techniques
- Nutrition and Health in Aging
- T-cell and B-cell Immunology
- Legionella and Acanthamoeba research
- Ocular Surface and Contact Lens
- Cytokine Signaling Pathways and Interactions
- Healthcare Regulation
- Microbial Fuel Cells and Bioremediation
Hospital de Clínicas de Porto Alegre
2013-2024
Universidade Federal do Rio Grande do Sul
2013-2024
Universidade de São Paulo
2021
Food & Nutrition
2021
Universidade Estadual Paulista (Unesp)
2021
Universidade de Ribeirão Preto
2021
Hospital de Clínicas
2018
Southwest Bahia State University
2017
Pontifícia Universidade Católica do Rio Grande do Sul
2014
Abstract Background Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% the patients. This can progress severely debilitating state known rheumatoid cachexia—without loss fat mass body weight—for which there little consensus terms diagnosis or treatment. study aims evaluate whether collagen‐induced (CIA) animal model also develops clinical functional features...
This study aimed to investigate the molecular pathways involved in muscle wasting an animal model of osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT) rats. Reduction protein syntheses, increased proteolysis and impaired regeneration are important related wasting, myogenin, MyoD, myostatin MuRF-1 some their markers. Female Wistar rats were allocated into two groups: OA (submitted ACLT) SHAM surgery without ACLT). Nociception, spontaneous exploratory locomotion body...
Systemic lupus erythematosus (SLE) is a multifactorial and autoimmune inflammatory disease with pleomorphic clinical manifestations involving different organs tissues. The study of murine models has provided better understanding these phenomena. Pristane-induced represents suitable model to factors that could influence the induction and/or progression SLE, including genetic factors. objective present was evaluate development evolution SLE after vitamin D supplementation in PIL model. Here,...
Purpose: The incidence of fungal infection after corneal transplant has increased significantly in recent years, especially Candida spp. This study aimed to evaluate the efficacy and safety addition cycloheximide Optisol-GS media decreasing growth strains. Methods: vitro laboratory measured colony 24 vials that were divided into 6 groups 4 each, as follows: (1) MIC/2 cycloheximide, (2) MIC (3) MICx5 (4) MICx10 from values obtained for each strain, (5) unsupplemented optisol-GS a positive...
Abstract To evaluate neuropsychiatric manifestations in the pristane-induced lupus (PIL) model, as well to immunoregulatory effects of vitamin D (vit-D) brain mice with PIL. Eighty female BALB/c were divided into six groups 90 (3 months) and 180 (6 days experimentation: CO3, CO6 (controls), PIL3, PIL6 (pristane-induced lupus), VD3 VD6 (PIL supplemented 1,25-dihydroxyvitamin D). Forced-swim, elevated plus maze Barnes behavioral tests performed. Expression pVDR was assessed by...
Epistylis riograndensis n. sp., a freshwater peritrich hosting symbiotic algae in its cytoplasm, was collected from an artificial lake, Botanical garden Southern Brazil. Its detailed morphology investigated using live and silver-stained specimens. The colonial sessile E. has elongate zooids measuring, on average, 162 μm length 45 width. A single contractile vacuole located near the infundibulum C-shaped macronucleus transversely adoral half of cell were also observed. oral infraciliature...
There is no consensus for diagnosis or treatment of RA muscle loss. We aimed to investigate metabolites in arthritic mice urine as biomarkers DBA1/J comprised collagen-induced arthritis (CIA) and control (CO) groups. Urine samples were collected at 0, 18, 35, 45, 55, 65 days disease subjected nuclear magnetic resonance spectroscopy. Metabolites identified using Chenomx Birmingham Metabolite libraries. The statistical model used principal component analysis, partial least-squares discriminant...
Abstract Introduction/objectives Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because the poor understanding signaling pathways involved SLE wasting, aim this study was to evaluate effects vitamin D supplementation on mice with pristane-induced lupus. Methods Balb/c lupus-like disease induced by pristane injection were randomized into three groups: (PIL; n = 10), + (PIL VD; 10) and healthy controls (CO; 8). Physical function...
Our objective was describing an algorithm to identify and prevent vascular injury in patients with intrapelvic components.Patients were defined as at risk injuries when components or cement migrated 5 mm more beyond the ilioischial line any of pelvic incidences (anteroposterior Judet view). In those patients, a serial investigation initiated by CT angiography, followed surgeon evaluation. The proceeded if necessary. main goal assure safe tissue plane between hardware vessels.In ten at-risk...
<h3>Background</h3> Rheumatoid arthritis (RA) patients have loss of muscle mass. The balance between protein synthesis and degradation is regulated by cytokines growth factors, named myokines, such as irisin myostatin. Myokines are mainly expressed skeletal exert systemic effects promoting crosstalk among different tissues. Irisin increases cortical bone mass its low levels related to atrophy obesity[,<sup>1, 2</sup> while myostatin a negative regulator regeneration has direct role in...
Keratitis caused by Acanthamoeba spp. is a rare disease, although increasingly common, especially among contact lens users. The occurrence and the devastating effect of this disease are associated with lack care in cleaning disinfecting lenses their storage cases, as well ineffective drugs to mainly eliminate parasite’s cysts. This work evaluated amoebicidal activity imidazolium salt 1-hexadecyl-3-methylimidazolium chloride (C16MImCl) against cysts two characterized isolates from keratitis...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system suffer from complications known as neuropsychiatric (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown hypovitaminosis lead to cognition deficits cerebral hypoperfusion in patients NPSLE. In this review article, we will address main features related supplementation serum...
<h3>Background:</h3> Neuropsychiatric lupus affects the central and peripheral nervous system. Physiopathology includes a blood-brain barrier disruption that leads to infiltration of autoantibodies immune cells into brain [1]. Vitamin D (VitD) has immunoregulatory properties have been explored in autoimmune diseases Pristane-induced (PIL) presents multiple classification criteria SLE, but neuropsychiatric manifestations are poorly studied [2]. The role VitD this context is unknown....
<h3>Background:</h3> Neuropsychiatric lupus (NPSLE) affects the central (CNS) and peripheral (PNS) nervous system. Complications in CNS associated with SLE include behavioral cognitive dysfunction, use of animal models becomes indispensable to better understand NPSLE [1]. Pristane-induced (PIL) presents multiple classification criteria SLE, but neuropsychiatric manifestations are poorly studied this model [2]. In context, vitamin D (VitD) has been for its immunomodulatory neuroprotective...
Decalcification of mineralized samples for microscopic analysis involves competing factors including decalcification time, preservation tissue integrity and cost. We investigated the utility different solutions studying joints in AG/WT, BALB/c, C57, DBA1/J mice Wistar rats. The hind paws rodents were removed fixed with 10% buffered formalin. Specimens divided randomly into three groups demineralization: nitric acid, 12.5% EDTA at room temperature 35 °C shaking. Sections stained hematoxylin...
<h3>Background</h3> Rheumatoid arthritis (RA) extra-articular features frequently involved metabolism alterations which in a context are known as rheumatoid cachexia. Loss of lean muscle mass, reduction grip strength and fatigue the most common signs RA. body weight food intake not usually part human cachexia, but have been demonstrated before animal models arthritis. Recently, Evans et al<sup>1</sup> published definition for cachexia that seems to fulfil condition. Therefore better...
<h3>Background:</h3> Myokines, such as irisin and myostatin, are cytokines growth factors mainly expressed in skeletal muscle, which is also their primary target tissue. They released into circulation exert a variety of systemic effects promoting crosstalk among different tissues [1]. Irisin known to retrieve disuse-induced bone loss by stimulating the osteoblast pathways, while myostatin was demonstrated be highly synovial rheumatoid arthritis (RA) subjects, with direct role...
<h3>Background:</h3> SLE is an autoimmune disease, characterized by the production of autoantibodies and tissue damage. The role vitamin D (VD) in has been increasingly explored. VD a steroid hormone notably involved regulation calcium bone homeostasis, its deficiency implicated development other connective diseases (2,3). study different murine models provided better understanding these phenomena. Pristane-induced lupus (PIL) represents suitable model to factors that could influence...