A5014307531- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biochemical effects in animals
- Liver Diseases and Immunity
- Cancer survivorship and care
- Hepatocellular Carcinoma Treatment and Prognosis
- Digestive system and related health
- Inflammatory Bowel Disease
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Escherichia coli research studies
- Exercise and Physiological Responses
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infant Nutrition and Health
- Adolescent and Pediatric Healthcare
University of Birmingham
2021-2023
NIHR Birmingham Biomedical Research Centre
2021-2023
National Institute for Health Research
2021-2023
University Hospitals Birmingham NHS Foundation Trust
2023
Cancer Research UK Clinical Trials Unit
2022
Queen Elizabeth Hospital
2021
Abstract Background Electronic patient-reported outcome (ePRO) systems are increasingly used in clinical trials to provide evidence of efficacy and tolerability treatment from the patient perspective. The aim this study is twofold: (1) describe how we developed an electronic platform for patients report their symptoms, (2) develop undertake usability testing ePRO solution use a cell therapy seeking early test feasibility system later phase studies. Methods An was designed be single arm,...
There is no consensus for diagnosis or treatment of RA muscle loss. We aimed to investigate metabolites in arthritic mice urine as biomarkers DBA1/J comprised collagen-induced arthritis (CIA) and control (CO) groups. Urine samples were collected at 0, 18, 35, 45, 55, 65 days disease subjected nuclear magnetic resonance spectroscopy. Metabolites identified using Chenomx Birmingham Metabolite libraries. The statistical model used principal component analysis, partial least-squares discriminant...
Introduction The use of electronic patient-reported outcome (ePRO) systems to capture PRO data in clinical trials is increasing; however, their feasibility, acceptability and utility advanced therapy medicinal products (ATMPs) are not yet well understood. This protocol describes a qualitative study that aims evaluate the feasibility ePRO using trial-specific system (the PROmics system) within an trial involving patients with immune-mediated inflammatory disease (rheumatoid arthritis, lupus,...
4012 Background: A previous study by our group using autologous monocyte-derived DC pulsed ex vivo with HepG2 cell lysate showed some clinical benefit evidence of antigen-specific T-cell responses in patients advanced HCC. The current trial reports the activity this vaccine combination TACE All also received low-dose cyclophosphamide to deplete regulatory T cells and thereby enhance vaccination. Methods: Patients intermediate stage HCC (performance status 0-2, Child Pugh A/B7) were...
The serine protease autotransporters of the Enterobacteriaceae (SPATEs) are a large family virulence factors commonly found in enteric bacteria. These secreted have diverse functions during bacterial infection, including adhesion, aggregation and cell toxicity. One such SPATE, Pic mucinase (protein involved colonisation) cleaves mucin, allowing cells to utilise mucin as carbon source penetrate gut mucus lining, thereby increasing mucosal colonisation. pic gene is widely distributed within...