A5058616234- Microbial infections and disease research
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Vectors
- Exercise and Physiological Responses
- Genomics and Phylogenetic Studies
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Cystic Fibrosis Research Advances
- Veterinary Equine Medical Research
- Bacillus and Francisella bacterial research
- Veterinary Orthopedics and Neurology
- Sports injuries and prevention
- Muscle metabolism and nutrition
- Poxvirus research and outbreaks
- Muscle and Compartmental Disorders
- Pharmacological Effects and Assays
- Orthopedic Surgery and Rehabilitation
- Cardiovascular Effects of Exercise
- Shoulder Injury and Treatment
- Bird parasitology and diseases
- Adipose Tissue and Metabolism
- Virology and Viral Diseases
- Coccidia and coccidiosis research
University of Alaska Fairbanks
2011-2024
University Medical Center Groningen
2024
University of Georgia
2018
New York State College of Veterinary Medicine
2018
Cornell University
2018
To address the role of bacterial infection in hatching failure wild geese, we monitored embryo development a breeding population Greater white-fronted geese (Anser albifrons) on Arctic Coastal Plain Alaska. During 2013, observed mortality normally developing embryos and collected 36 addled eggs for analysis. We also 17 infertile comparison. Using standard culture methods gene sequencing to identify bacteria within eggs, identified potentially novel species Neisseria 33 Macrococcus...
Abstract Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis , ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from rabbit tick ( Haemophysalis leporis-palustris ) 1938. Since then, F. has been wildlife and humans throughout state. Serologic surveys have found measurable antibodies with prevalence ranging < 1% to 50% 4% 18% for selected populations of species humans, respectively. We...
Exercise is associated with the development of oxidative stress, but specific source and mechanism production pro-oxidant chemicals during exercise has not been confirmed. We used equine skeletal muscle mitochondria to test hypothesis that hyperthermia acidosis affect mitochondrial oxygen consumption reactive species (ROS). Skeletal biopsies were obtained at rest, after an acute episode fatiguing exercise, a 9-wk conditioning program increase aerobic fitness. Mitochondrial ROS measured...
Serum muscle enzymes in endurance sled dogs peak within 2-4 days of racing. The object this study was to compare mid-race serum chemistry profiles, select hormones, and markers inflammation the acute phase response that successfully completed half 2015 Yukon Quest dog race (n = 14) those who developed clinical exertional rhabdomyolysis (ER) 5). Concentrations phosphorus ER were moderately elevated compared healthy (median 5.5 vs. 4.25 mg/dL, P 0.001) at mid race. ALT, AST, CK show a marked...
A combination of butorphanol-azaperone-medetomidine was used to immobilize four captive caribou (Rangifer tarandus granti) in Palmer, Alaska, US. The average induction time for this 5:17±2:06 min. Inductions were smooth, and recoveries excellent. This drug may provide an alternative the use potent opioids immobilizing caribou.
Whole blood (WB) is commonly used to assess mercury (Hg) exposure in mammals, but handling and shipping samples collected remote areas can be difficult. We describe validate use of cellulose filter paper (FP) for quantifying WB total Hg concentration. Advantec Nobuto® FP was soaked with bottlenose dolphin (Tursiops truncatus) or harbor seal (Phoca vitulina) (collected between March July 2012), then air dried. Untreated blood-soaked FPs were analyzed eluted phosphate-buffered saline (PBS) the...
During the summers of 2013 and 2014, isolates a novel Gram-stain-negative coccus in genus Neisseriawere obtained from contents nonviable greater white-fronted goose (Anseralbifrons) eggs on Arctic Coastal Plain Alaska. We used polyphasic approach to determine whether these represent species. 16S rRNA gene sequences, 23S chaperonin 60 sequences suggested that Alaskan are members distinct species is most closely related Neisseria canis, Neisseriaanimaloris Neisseriashayeganii. Analysis rplF...
Long distance racing sled dogs are fed diets high in fat since lipid metabolism has long been thought to be the major substrate utilised during endurance racing. However, recent studies suggests that equally, if not more, dependent on carbohydrate metabolism. Considering metabolic disparity regarding energetics of exercise, our study aimed explore serum metabolomic profiles running a 1,609 km (1000 mile) race. We hypothesised there would amino acid depletion due gluconeogenesis and...
The objective of this study was to investigate the effects running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and factor binding proteins 1 3 (IGFBP-1 IGFBP-3). Serum examined from 12 dogs prior race, at midrace (approximately 690 km), again finish. IGF-1, IGFBP-1, IGFBP-3 were assessed using radioimmunoassay or enzyme linked immune-absorbance assays. Mean prerace concentrations significantly higher than end-race 215.93 ± 80.51 ng/mL, 54.29...
The intracellular environment of skeletal muscle can develop pronounced hyperthermia and acidosis during strenuous exercise, these alterations in the typical conditions have been shown to alter mitochondrial respiration. However, impact on ATP synthesis is poorly understood. We used Thoroughbred racehorses test hypothesis that both decrease rate synthesis, but athletic conditioning mitigates this loss phosphorylation capacity. Isolated mitochondria were harvested from before after a 9-week...
Introduction The purpose of this study was to evaluate medical record data from the 2018–2020 Yukon Quest International Sled Dog race examine injury patterns and risk factors for dogs competing in multi-day ultra-endurance events. Specifically, we summarized injuries illnesses that resulted canine athletes being removed (“dropped”) competition, orthopedic diagnosed both dropped finished dogs. Methods records 989 started were examined, but only teams went on finish included, a total 711...
We report here the draft genome sequence of a unique Neisseria strain that was isolated from greater white-fronted goose (Anser albifrons) egg. The sequencing performed with an Illumina MiSeq system, and consists 275 contigs. total is 2,397,978 bp long has G+C content 46.4%.
To evaluate the serum concentrations of myostatin and growth differentiation factor 15 (GDF-15) in Alaskan Husky sled dogs participating a 350-mile (560-km) race an older population, to examine correlations between changes body condition scores (BCSs).Dogs were recruited from 3 teams Huskies Alaskan-Yukon Quest sled-dog retirees research colony.Serum samples BCSs collected prior racing, midway, postrace; cohort (13 14 years). Myostatin GDF-15 assessed using commercially available ELISA...
Abstract An expected consequence of climate warming is an expansion the geographic distribution biting insects and associated arthropod-borne diseases (arboviruses). Emerging reemerging arboviruses that can affect human health are likely to pose significant consequences for Northern communities where access resources limited. In North American Arctic, little known about arboviruses. Thus, in 2019, we sampled Nunavik (Kuujjuaq), Nunavut (Igloolik, Karrak Lake Cambridge Bay), Northwest...