A5034644521- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Plant Pathogenic Bacteria Studies
- Infections and bacterial resistance
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Protist diversity and phylogeny
- Bacteriophages and microbial interactions
- Viral Infections and Vectors
- Identification and Quantification in Food
- Plant Disease Resistance and Genetics
- Nosocomial Infections in ICU
- Angiogenesis and VEGF in Cancer
- Oral microbiology and periodontitis research
- Geology and Paleoclimatology Research
- Mosquito-borne diseases and control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vibrio bacteria research studies
- Microscopic Colitis
- Probiotics and Fermented Foods
- Diabetic Foot Ulcer Assessment and Management
- Ethics and Legal Issues in Pediatric Healthcare
- Mesenchymal stem cell research
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
Universitat de Miguel Hernández d'Elx
2009-2025
Instituto de investigación sanitaria y biomédica de Alicante
2023
Instituto de Agroquímica y Tecnología de Alimentos
2021
Consejo Superior de Investigaciones Científicas
2021
Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures
2019-2020
German Center for Infection Research
2019
Secretaria da Saúde
2018
Alteromonas macleodii is a marine gammaproteobacterium with widespread distribution in temperate or tropical waters. We describe three genomes of isolates from surface waters around Europe (Atlantic, Mediterranean and Black Sea) compare them previously described deep isolate (AltDE) that belongs to widely divergent clade. The are quite similar, the most being Sea (BS11) isolate. contain several genomic islands different gene content. recruitment very similar fragments metagenomes locations...
Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure clonality at level. We show that S. complex is divided into 23 monophyletic lineages, most which harbour strains all degrees human virulence. Lineage Sm6 comprises highest rate human-associated...
We have compared genomes of Alteromonas macleodii "deep ecotype" isolates from two deep Mediterranean sites and surface samples the Aegean English Channel. A total nine different were analyzed. They belong to five clonal frames (CFs) that differ among them by approximately 30,000 single-nucleotide polymorphisms (SNPs) over their core genomes. Two CFs contain three strains each with nearly identical (∼100 SNPs genome). One had representatives isolated taken more than 1,000 km away, 2,500 m...
OXA-48 is the most common carbapenemase in Germany and one of frequent carbapenemases worldwide. Several reports have associated blaOXA-48 with a virulent host phenotype. To challenge this hypothesis, 35 OXA-48-producing clinical isolates Escherichia coli (n=15) Klebsiella pneumoniae (n=20) were studied vitro, vivo by whole-genome sequencing. Clinical belonged to 7 different sequence types (STs) E. 12 STs K. pneumoniae. In 27/35 was located on 63 kb IncL plasmid. Horizontal gene transfer...
We have analyzed a natural population of the marine bacterium, Alteromonas macleodii, from single sample seawater to evaluate genomic diversity present. performed full genome sequencing four isolates and 161 metagenomic fosmid clones, all which were assigned A. macleodii by sequence similarity. Out strain genomes, deep ecotype (AltDE1) represented different genome, whereas AltDE2 AltDE3 identical previously described AltDE. Although core (~80%) had an average nucleotide identity 98.51%, both...
Alteromonas is a genus of marine bacteria that very easy to isolate and grow in the laboratory. There are genomes available species macleodii from different locations around world an sp. isolated sediment Korea. We have analyzed two strains classified by 16S rRNA (>99% similarity) as recently described australica, opposite ends world; A. australica DE170 was South Adriatic (Mediterranean) at 1000 m depth while H17T sea water sample collected St Kilda Beach, Tasman Sea. Although these belong...
Abstract To trace the routes and frequencies of transmission Clostridioides difficile in a tertiary-care hospital Madrid (Spain), we sequenced genomes from all C . isolates collected over 36 months (2014–2016) that were indistinguishable any other isolate by PCR ribotyping. From total 589 infection cases, cultivated PCR-ribotyped 367 (62%), which 265 genome-sequenced. Based on close relatedness successively (≤2 SNPs difference their genomes), whole-genome sequencing revealed 17 independent,...
Patients ineligible for lung transplant with end-stage Interstitial Lung Disease (ILD) on Extra-Corporeal Membrane Oxygenation (ECMO) face an appalling prognosis limited therapeutic options. Due to the beneficial effect of Mesenchymal Stromal Cells (MSC) inflammatory, immunological and infectious diseases, cell therapy has been proposed as option, but administration is hampered by ECMO. Cryopreserved Wharton-jelly derived MSC (WJ-MSC) were conveniently diluted directly applied consecutively...
The use of carbon monoxide (CO) as a biological energy source is widespread in microbes. In recent years, the role CO oxidation superficial ocean waters has been shown to be an important supplement for heterotrophs (carboxydovores). key enzyme dehydrogenase was found both isolates and metagenomes from ocean's photic zone, where continuously generated by organic matter photolysis. We have also genes that code forms I (low affinity) II (high fosmids metagenomic library 3,000-m depth...
The genome of Alteromonas macleodii strain ATCC 27126(T) has been resequenced and closed into a single contig. We describe here the this important globally distributed marine bacterium.
The aim of this study was to characterize the Acinetobacter calcoaceticus clinical isolate AC_2117 with novel carbapenem-hydrolysing class D β-lactamase (CHDL) OXA-679.Identification species and β-lactamases verified by genome sequencing (PacBio) phylogenetic analyses. Antibiotic susceptibility transformants harbouring cloned blaOXA-679 evaluated using antibiotic gradient strips microbroth dilution. OXA-679 purified heterologously kinetic parameters were determined spectrometry or isothermal...
Phascolarctobacterium faecium is a strict anaerobe belonging to the Firmicutes phylum that found abundantly in human gastrointestinal tract. Here, we report complete genome sequence of P. G 104, strain isolated from fresh stool sample healthy lean donor.
Globally, a leg is amputated approximately every 30 seconds, with an estimated 85 percent of these amputations being attributed to complications arising from diabetic foot ulcers (DFU), as stated by the American Diabetes Association. Peripheral arterial disease (PAD) risk factor resulting in DFU and can, either independently or conjunction diabetes, lead recurring, slow-healing amputations. According guidelines amputation recommended treatment for patients no-option critical ischemia limb...
Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analysed an international collection the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure clonality at level. We show that S. complex is divided into 23 monophyletic lineages, most which harboured strains all degrees human virulence. Lineage Sm6 comprised highest rate human-associated...