A5005552103- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Plant Pathogenic Bacteria Studies
- Microbial Applications in Construction Materials
- Bacteriophages and microbial interactions
- Wound Healing and Treatments
- Autoimmune Bullous Skin Diseases
- Antimicrobial Peptides and Activities
- Health, Education, and Cultural Studies
- Antifungal resistance and susceptibility
Universität Hamburg
2019-2023
Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure clonality at level. We show that S. complex is divided into 23 monophyletic lineages, most which harbour strains all degrees human virulence. Lineage Sm6 comprises highest rate human-associated...
Fluorescently labeled bacterial cells have become indispensable for many aspects of microbiological research, including studies on biofilm formation as an important virulence factor various opportunistic bacteria environmental origin such Stenotrophomonas maltophilia. Using a Tn7-based genomic integration system, we report the construction improved mini-Tn7 delivery plasmids labeling S. maltophilia with sfGFP, mCherry, tdTomato and mKate2 by expressing their codon-optimized genes from...
Microorganisms living in a biofilm are much more tolerant to antibiotics and antimicrobial substances than planktonic cells are. Thus, the treatment of infections caused by microorganisms biofilms is extremely difficult. Nosocomial (among others) S. maltophilia , particularly lung infection among CF patients, have increased prevalence recent years. The intrinsic multidrug resistance tolerance agents its make significance our research based on understanding common mechanisms involved...
Biofilms are a major problem in hard-to-heal wounds. Moreover, they composed of different species and often tolerant to antimicrobial agents. At the same time, interspecific synergy and/or competition occurs when some bacterial clash. For this reason, tolerance two dual-species wound biofilm models Pseudomonas aeruginosa Staphylococcus aureus or Enterococcus faecium against antimicrobials dressings were analyzed quantitatively by confocal laser scanning microscopy (CLSM). The results...
Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analysed an international collection the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure clonality at level. We show that S. complex is divided into 23 monophyletic lineages, most which harboured strains all degrees human virulence. Lineage Sm6 comprised highest rate human-associated...
Stenotrophomonas maltophilia is a multidrug-resistant human opportunistic pathogen. S. contributes to disease progression in cystic fibrosis patients and found wounds infected tissues on catheter surfaces. Due its well-known multidrug resistance, it difficult treat infections. Strain-specific susceptibility antimicrobials has also been reported several studies. Recently, three fungal diorcinols 14 rubrolides were shown reduce K279a biofilm formation. Based these initial findings, we...
<p><strong>Stenotrophomonas maltophilia</strong><strong> is one of the most frequently isolated multidrug resistant opportunistic pathogens. It contributes to disease progression in cystic fibrosis patients and found wounds, other infected tissues on catheter surfaces. Only little known key processes linked biofilm formation S. maltophilia a broader basis. Thus aim this study was identification involved global level. Therefore, we...
<p><em>Stenotrophomonas maltophilia</em> is a multidrug resistant human nosocomial opportunistic pathogen. It contributes to disease progression in cystic fibrosis patients and found wounds, other infected tissues on catheter surfaces. <em>S. globally distributed forms 23 distinct phylogenetic clusters (1, 2). Due its resistance, it extremely difficult heal caused infections. Colistin last-resort antibiotic against pathogens. However,...