Xavier Coves

ORCID: 0000-0002-8970-8907
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About
Contact & Profiles
Research Areas
  • Bacterial biofilms and quorum sensing
  • Infections and bacterial resistance
  • Bacteriophages and microbial interactions
  • Plant Pathogenic Bacteria Studies
  • Microbial Fuel Cells and Bioremediation
  • Membrane Separation Technologies
  • Bacterial Genetics and Biotechnology
  • Cystic Fibrosis Research Advances
  • Antimicrobial Peptides and Activities

Universitat Autònoma de Barcelona
2015-2025

Abstract Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic phenotypic diversity between the isolates was high making detected strain-specific. Despite this, clinical origin strains, some common pairs. For most pairs, P. exoproducts affected biofilm formation reduced growth vitro its S. counterpart. Conversely, did not impair stimulated swarming motility ....

10.1038/s41598-022-07018-5 article EN cc-by Scientific Reports 2022-03-01

The pathogenicity of Stenotrophomonas maltophilia is regulated in part by its quorum sensing (QS) system. main QS signaling molecule S. known as diffusible signal factor (DSF), and the rpf gene cluster responsible for synthesis perception. Two variants have been previously described, rpf-1 rpf-2, which differ basically conditions under DSF produced. Here, correlations between variant antibiotic susceptibility, LPS electrophoretic profiles virulence-related phenotypes were evaluated a...

10.3389/fmicb.2020.01160 article EN cc-by Frontiers in Microbiology 2020-06-03

Fluorescently labeled bacterial cells have become indispensable for many aspects of microbiological research, including studies on biofilm formation as an important virulence factor various opportunistic bacteria environmental origin such Stenotrophomonas maltophilia. Using a Tn7-based genomic integration system, we report the construction improved mini-Tn7 delivery plasmids labeling S. maltophilia with sfGFP, mCherry, tdTomato and mKate2 by expressing their codon-optimized genes from...

10.1128/aem.00317-23 article EN cc-by Applied and Environmental Microbiology 2023-05-17

Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. It is a remarkably adaptable species capable of thriving various environments, thanks to the plasticity its genome diverse array genes that encode wide range functions. Among these functions, one notable trait remarkable ability resist antimicrobial agents, primarily through mechanisms regulate diffusion across cell membranes. We have investigated Mla ABC transport system S. ,...

10.3389/fcimb.2024.1346565 article EN cc-by Frontiers in Cellular and Infection Microbiology 2024-02-26

Stenotrophomonas maltophilia are opportunistic, multi-drug-resistant Gram-negative pathogens increasingly prevalent in clinical settings. Quorum sensing (QS) systems play a crucial role their pathogenesis, coordinating bacterial populations and enabling interactions within polymicrobial communities. While not the primary QS mechanism S. maltophilia, these bacteria can respond to acyl-homoserine lactone (AHL)-type autoinducers. Some isolates exhibit AHL-quorum quenching activity, though...

10.1038/s41598-025-92749-4 article EN cc-by-nc-nd Scientific Reports 2025-03-12

Stenotrophomonas maltophilia is an environmental bacterium as well emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate population behavior and regulate virulence processes but can also respond exogenous N-acyl-homoserine lactone (AHL) signals produced by neighboring bacteria. The effect of these QS on global gene expression this species remains, however, unknown. Whole-transcriptome sequencing...

10.1128/aem.00635-23 article EN cc-by Applied and Environmental Microbiology 2023-06-05

We report the draft genome sequence of Stenotrophomonas maltophilia UV74, isolated from a vascular ulcer. This shall contribute to understanding evolution and pathogenicity this species, particularly regarding isolates clinical origin.

10.1128/genomea.00611-15 article EN Genome Announcements 2015-06-12

ABSTRACT Stenotrophomonas maltophilia is an environmental bacterium and it also emerging opportunistic multidrug-resistant pathogen. It uses the endogenous DSF quorum sensing (QS) system to coordinate population behaviors regulate virulence processes but can respond exogenous AHL signals produced by neighboring bacteria. Whole-transcriptome sequencing analyses were performed for S. K279a in exponential stationary phases as well cultures after treatment with or AHLs. The results revealed that...

10.1101/2022.08.31.506136 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2022-09-03
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