A5033683918- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
- Menstrual Health and Disorders
- Hemophilia Treatment and Research
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- COVID-19 Impact on Reproduction
- Blood Coagulation and Thrombosis Mechanisms
- Urticaria and Related Conditions
- Vitamin K Research Studies
- Stress Responses and Cortisol
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
Semmelweis University
2023-2024
Research Network (United States)
2024
Hungarian Research Network
2024
University of Pecs
2022
Hungarian Academy of Sciences
2017-2019
HUN-REN Institute of Experimental Medicine
2017-2019
Observations of women and clinicians indicated that the prevalence menstrual cycle problems has escalated during COVID-19 pandemic. However, it was not clear whether observed changes were related to vaccination, disease itself or pandemic-induced psychological alterations. To systematically analyze this question, we conducted a human online survey in aged between 18 65 Hungary. The 1563 individuals analyzed our study relation infection, pandemic mental health. We found no association vaccine...
Social behavior is important for our well-being, and its dysfunctions impact several pathological conditions. Although the involvement of glutamate undeniable, relevance vesicular transporter type 3 (VGluT3), a specific transporter, in control social not sufficiently explored. Since midbrain median raphe region (MRR) implicated nucleus contains high amount VGluT3+ neurons, we compared male VGluT3 knock-out (KO) VGluT3-Cre mice, latter after chemogenetic MRR-VGluT3 manipulation. Appropriate...
BackgroundIn hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE), bradykinin-mediated submucosal and/or subcutaneous dominates the clinical picture. The of can lead over-activation complement system. Complement plays an important role in all types hypersensitivity reactions. On other hand, during degranulation mast cells, heparin is also released amongst substances. Heparin activate plasma kinin-kallikrein system, leading bradykinin generation. These observations suggest...
Due to the similarity between pathomechanism of SARS-CoV-2 infections and hereditary angioedema due C1-inhibitor deficiency (C1-INH-HAE), a possibility emerged that C1-INH-HAE may worsen course infection, or infection influence severity (HAE) attacks in patients. Our study aimed evaluate effects COVID-19 pandemic on quality life (QoL) Hungarian patients, survey acute post COVID symptoms (PCS), vaccination coverage side vaccines this patient population. 93 patients completed our questionnaire...
C1 inhibitor (C1INH) functions as a key endogenous of contact pathway coagulation factors XII, XI and plasma kallikrein (PKa). Patients with congenital deficiency in C1INH suffer from rare swelling disorder called hereditary angioedema (HAE) caused by excess bradykinin generation. HAE also have elevated circulating levels markers activation an increased risk venous thromboembolism, phenotypes recapitulated C1INH-deficient mice. We sought to evaluate the molecular mechanism which leads basal...