A5051843313- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- Ion Channels and Receptors
- Peroxisome Proliferator-Activated Receptors
- Orthopaedic implants and arthroplasty
- Immune cells in cancer
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Studies on Chitinases and Chitosanases
- Chronic Myeloid Leukemia Treatments
- Osteoarthritis Treatment and Mechanisms
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Invertebrate Immune Response Mechanisms
- Total Knee Arthroplasty Outcomes
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Neurobiology and Insect Physiology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Bone and Joint Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
Tampere University Hospital
2013-2024
Tampere University
2013-2024
Abstract We report the first long-term follow-up of a randomized trial (NCT04978259) addressing effects remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of 208 patients recruited 11 Finnish hospitals, 198 survived, whom 181 (92%) completed follow-up. At year, self-reported occurred in 85% 86% standard care (SoC) (RR 0.94, 95% CI 0.47-1.90). infer no convincing difference between SoC quality life or symptom (...
YKL-40 is associated with tissue injury and inflammation, consequently to diseases in which these mechanisms lead degradation, for example, asthma rheumatoid arthritis. The purpose of the present study was investigate if also a significant factor osteoarthritis (OA) by assessing associations mediators related pathogenesis OA: cartilage destructing matrix metalloproteinases (MMPs) proinflammatory cytokines interleukin-6 (IL-6) interleukin-17 (IL-17). Cartilage, synovial fluid (SF), plasma...
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved nociception neurogenic inflammation. We showed recently that TRPA1 mediates cartilage degradation joint pain the MIA-model of osteoarthritis (OA) suggesting hitherto unknown role for OA. Therefore, we aimed to investigate whether functional human OA chondrocytes. Expression primary chondrocytes was assessed by qRT-PCR Western blot. The functionality channel...
Introduction Hip arthroplasty is the standard treatment of a painful hip destruction. The use modern metal-on-metal (MOM) bearing surfaces gained popularity in total arthroplasties during last decade. Recently, worrisome failures due to adverse reaction metal debris (ARMD), including pseudotumor response, have been widely reported. However, pathogenesis this remains poorly understood. aim present study was investigate ARMD response by flow cytometry approach. Methods Sixteen patients with...
Abstract Cobalt (Co) is vital for cells in trace amounts, but excessive exposure to Co possible due surgical devices such as artificial metal‐on‐metal joints. Cobalt( II ) chloride (CoCl 2 has also been shown imitate hypoxic conditions by stabilizing the transcription factor hypoxia‐inducible factor‐1α ( HIF ‐1α). The purpose of this study was investigate immunomodulatory action CoCl investigating its effects on expression inflammatory genes macrophages. following factors were assessed:...
Abstract Macrophage polarization refers to the ability of these cells adopt different functional phenotypes according their environment. Mitogen‐activated protein kinase phosphatase‐1 (MKP‐1) is known regulate classical lipopolysaccharide (LPS)‐induced pro‐inflammatory macrophage activation and inflammatory response. Here, we investigated effects MKP‐1 on anti‐inflammatory healing‐promoting phenotype induced by cytokines IL‐4 IL‐13 examined potential mediator role in glucocorticoid two...
Peroxisome proliferator-activated receptor (PPAR) agonists are widely used drugs in the treatment of diabetes and dyslipidemia. In addition to their metabolic effects, PPAR isoforms PPARα PPARγ also involved regulation immune responses inflammation. present study, we investigated effects a dual PPARγ/α agonist muraglitazar on inflammatory gene expression activated macrophages carrageenan-induced inflammation mouse. J774 murine were by lipopolysaccharide (LPS) treated with muraglitazar,...
Tristetraprolin (TTP) is a <i>trans</i>-acting factor that can regulate mRNA stability by binding to the <i>cis</i>-acting AU-rich element (ARE) in 3′-untranslated region mRNAs of certain transiently expressed genes. The best-studied target TTP tumor necrosis (TNF)-α. By ARE, increases degradation TNF-α mRNA, thereby reducing expression TNF-α. We examined effects cAMP analogs and cAMP-elevating agents forskolin β<sub>2</sub>-agonists on lipopolysaccharide (LPS)-induced protein quantitative...
Excessive alternative macrophage activation contributes to fibrosis. We studied the effects of nortrachelogenin, major lignan component Pinus sylvestris knot extract, on (M2) activation. J774 murine and THP-1 human macrophages were cultured with IL-4+IL-13 induce activation, together extract its components. Effects nortrachelogenin also in bleomycin-induced dermal fibrosis model. Knot significantly decreased expression markers-arginase 1 (97.4 ± 1.3% inhibition at 30 μg/mL) CCL13 PDGF...
Abstract We report the short- and long-term results of SOLIDARITY Finland on mortality other patient-important outcomes in patients hospitalised for COVID-19. Between 08/2021 03/2023, we randomised 156 15 hospitals. In imatinib group, 7.2% had died at 30 days 13.3% 1 year standard care group 4.1% 8.3% (adjusted HR 1.09, 95% CI 0.23–5.07). a meta-analysis trials versus (n=732), allocation to was associated with risk ratio 0.73 (95% 0.32–1.63). At 1-year, self-reported recovery occurred 79.0%...
Abstract Background Coronavirus disease 2019 (COVID-19) patients frequently suffer from long-term sequelae, often called “long COVID” or “post COVID-19 condition”. Remdesivir, given in early disease, decreases the risk of hospitalization and potentially mortality. No randomized trials have thus far published follow-up data on any drug treatment. We investigated effects remdesivir a range patient-important outcomes at one year. Methods Between July 2020 January 2021, an open-label multicenter...
Abstract Peroxisome proliferator-activated receptor (PPAR) agonists, fibrates and thiazolidinediones, are commonly used drugs in the treatment of dyslipidemia diabetes. Their targets, PPARα PPARγ, have also been shown to a role regulation inflammatory responses linking metabolism inflammation. In present study we investigated effects PPAR agonists on macrophage activation. addition proinflammatory classical activation, focused interleukin (IL) 4 13 -induced alternative activation which is...