Clinical studies have revealed a number of important risk factors for postoperative infection following total knee arthroplasty. Because the small numbers cases in those studies, there is obtaining false-negative results statistical analyses. The purpose present study was to determine primary and revision replacement large register-based series.A 43,149 arthroplasties, registered Finnish Arthroplasty Register, were followed median three years. Register Hospital Discharge searched surgical...

Background: Diabetes and obesity are common in patients undergoing joint replacement. Studies analyzing the effects of diabetes on occurrence periprosthetic infection have yielded contradictory results, combined these conditions not known. Methods: The one-year incidence infections was analyzed a single-center series 7181 primary hip knee replacements (unilateral simultaneous bilateral) performed between 2002 2008 to treat osteoarthritis. data regarding (defined according Centers for Disease...

Total knee replacements (TKRs) are being increasingly performed in patients aged < or = 65 years who often have high physical demands. We investigated the relation between age of patient and prosthesis survival following primary TKR using nationwide data collected from Finnish Arthroplasty Register.From Jan 1, 1997 through Dec 31, 2003, 32,019 TKRs for secondary osteoarthritis were reported to Register. The followed until end 2004. During follow-up, 909 revised, 205 (23%) due infection 704...

Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also hand pointing to obesity-related metabolic that influences on the pathogenesis of OA. Leptin adipokine regulating energy balance, and it has recently been related arthritis inflammation as a proinflammatory factor. In present paper, effects leptin human OA cartilage were studied. alone or combination with IL-1 enhanced expression iNOS COX-2, production NO,<mml:math...

Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and coronary heart disease (CHD) risk. We determined the apoE phenotypes in 1577 youths aged 3 to 18 years 1980. The subjects were randomly selected from five areas Finland. ApoE phenotyping was performed directly by isoelectric focusing immunoblotting. allele frequencies population sample epsilon 2 = 0.039, 0.767, 4 0.194. There no differences phenotype distribution between East West Finland or sexes....

Abstract Introduction Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation arthritis. The purpose of the present study was investigate association effects adiponectin on cartilage destruction osteoarthritis (OA). Methods Cartilage blood samples were collected from 35 male OA patients undergoing total knee replacement surgery. Preoperative radiographs evaluated using Ahlbäck classification criteria...

The introduction and development of new total knee arthroplasty (TKA) implant designs are industry driven. To date, an adequately powered randomized controlled trial (RCT) to provide evidence the superiority novel over conventional ones is often lacking. aim our RCT was investigate functional outcomes a TKA design compared with 2 designs. Primary outcome difference in change Oxford Knee Score (OKS) at years. Secondary were Forgotten Joint Score, 15D quality life questionnaire, UCLA activity...

Objectives: Resistin is an adipocytokine that has been related to inflammation and insulin resistance. Following knee injury, elevated levels of resistin have found in synovial fluid (SF) while very little known about the role osteoarthritis (OA). The aim present study was investigate OA joints determine if it associated with inflammatory catabolic factors joints.Method: SF, plasma, cartilage samples were collected from 88 patients undergoing replacement surgery. measured by enzyme-linked...

Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several cytokines signal through the JAK-STAT pathway, which is negatively regulated by suppressors of cytokine signalling (SOCS) proteins. Since SOCS protein levels can profoundly modulate cellular responses to cytokines, we have investigated their expression chronic RA.

Objectives: Interleukin (IL)-10 functions as an anti-inflammatory cytokine in rheumatoid arthritis (RA). New IL-10 family cytokines IL-19, IL-20, IL-22, IL-24, and IL-26 have recently been discovered. Information concerning the expression function of these autoimmune diseases is currently limited. The aim this study was to investigate their RA.

Background — Randomized trials evaluating efficacy of local infiltration analgesia (LIA) have been published but many these lack standardized analgesics. There is a paucity reports on the effects LIA functional capability and quality life.Methods 56 patients undergoing unilateral total knee arthroplasty (TKA) were randomized into 2 groups in this placebo-controlled study with 12-month follow-up. In group, mixture levobupivacaine (150 mg), ketorolac (30 adrenaline (0.5 mg) was infiltrated...

YKL-40 is associated with tissue injury and inflammation, consequently to diseases in which these mechanisms lead degradation, for example, asthma rheumatoid arthritis. The purpose of the present study was investigate if also a significant factor osteoarthritis (OA) by assessing associations mediators related pathogenesis OA: cartilage destructing matrix metalloproteinases (MMPs) proinflammatory cytokines interleukin-6 (IL-6) interleukin-17 (IL-17). Cartilage, synovial fluid (SF), plasma...

In some patients, for unknown reasons pain persists after joint replacement, especially in the knee. We determined prevalence of persistent following primary hip or knee replacement and its association with disorders glucose metabolism, metabolic syndrome (MetS), obesity.

Objectives: Fibroblast growth factor (FGF)-2 is a member of the FGF family and found in synovial fluid patients with osteoarthritis (OA). The aim this study was to investigate effects FGF-2 on human OA cartilage/chondrocytes by examining association between cartilage degrading enzymes matrix metalloproteinase (MMP)-1 MMP-13 major components aggrecan collagen II.

Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved nociception neurogenic inflammation. We showed recently that TRPA1 mediates cartilage degradation joint pain the MIA-model of osteoarthritis (OA) suggesting hitherto unknown role for OA. Therefore, we aimed to investigate whether functional human OA chondrocytes. Expression primary chondrocytes was assessed by qRT-PCR Western blot. The functionality channel...

Interleukin-6 (IL-6) is involved in the pathogenesis of various inflammatory diseases, like rheumatoid arthritis (RA). In present study, we investigated role IL-6 osteoarthritis (OA) patients and effects stilbenoids monomethyl pinosylvin on expression cartilage matrix components aggrecan collagen II cytokine human OA chondrocytes. Synovial fluid plasma samples were obtained from 100 with severe [BMI 29.7 (8.3) kg/m2, age 72 (14) years, median (IQR); 62/38 females/males] undergoing total knee...

Transient receptor potential (TRP) ion channels are expressed in neuronal and some non-neuronal cells involved particularly pain thermosensation. We previously showed that TRPA1 is functionally human osteoarthritic (OA) chondrocytes mediates inflammation, cartilage degradation, monosodium-iodoacetate-induced experimental OA. In the present study, we explored expression of TRP-channels primary OA investigated whether drugs used treatment OA, ibuprofen glucocorticoids, have effects on...