- Adipokines, Inflammation, and Metabolic Diseases
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Ion Channels and Receptors
- Rheumatoid Arthritis Research and Therapies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Cytokine Signaling Pathways and Interactions
- Studies on Chitinases and Chitosanases
- Autoimmune and Inflammatory Disorders Research
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurobiology and Insect Physiology Research
- Exercise and Physiological Responses
- Spondyloarthritis Studies and Treatments
- NF-κB Signaling Pathways
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Fibroblast Growth Factor Research
- Plant chemical constituents analysis
- Inflammasome and immune disorders
- Biomarkers in Disease Mechanisms
Tampere University
2015-2024
Tampere University Hospital
2014-2024
Mount Sinai Hospital
2009
University of Toronto
2009
GlaxoSmithKline (United Kingdom)
2001
The Royal Free Hospital
2001
University College London
2001
Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also hand pointing to obesity-related metabolic that influences on the pathogenesis of OA. Leptin adipokine regulating energy balance, and it has recently been related arthritis inflammation as a proinflammatory factor. In present paper, effects leptin human OA cartilage were studied. alone or combination with IL-1 enhanced expression iNOS COX-2, production NO,<mml:math...
Low mitochondrial number and activity have been suggested as underlying factors in obesity, type 2 diabetes, metabolic syndrome. However, the stage at which dysfunction manifests adipose tissue after onset of obesity remains unknown. Here we examined subcutaneous (SAT) samples from healthy monozygotic twin pairs, 22.8–36.2 years age, who were discordant (ΔBMI &gt;3 kg/m2, mean length discordance 6.3 ± 0.3 years, n = 26) concordant &lt;3 14) for body weight, assessed their detailed...
Abstract Introduction Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation arthritis. The purpose of the present study was investigate association effects adiponectin on cartilage destruction osteoarthritis (OA). Methods Cartilage blood samples were collected from 35 male OA patients undergoing total knee replacement surgery. Preoperative radiographs evaluated using Ahlbäck classification criteria...
Objectives: Resistin is an adipocytokine that has been related to inflammation and insulin resistance. Following knee injury, elevated levels of resistin have found in synovial fluid (SF) while very little known about the role osteoarthritis (OA). The aim present study was investigate OA joints determine if it associated with inflammatory catabolic factors joints.Method: SF, plasma, cartilage samples were collected from 88 patients undergoing replacement surgery. measured by enzyme-linked...
YKL-40 is associated with tissue injury and inflammation, consequently to diseases in which these mechanisms lead degradation, for example, asthma rheumatoid arthritis. The purpose of the present study was investigate if also a significant factor osteoarthritis (OA) by assessing associations mediators related pathogenesis OA: cartilage destructing matrix metalloproteinases (MMPs) proinflammatory cytokines interleukin-6 (IL-6) interleukin-17 (IL-17). Cartilage, synovial fluid (SF), plasma...
Objectives: Fibroblast growth factor (FGF)-2 is a member of the FGF family and found in synovial fluid patients with osteoarthritis (OA). The aim this study was to investigate effects FGF-2 on human OA cartilage/chondrocytes by examining association between cartilage degrading enzymes matrix metalloproteinase (MMP)-1 MMP-13 major components aggrecan collagen II.
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved nociception neurogenic inflammation. We showed recently that TRPA1 mediates cartilage degradation joint pain the MIA-model of osteoarthritis (OA) suggesting hitherto unknown role for OA. Therefore, we aimed to investigate whether functional human OA chondrocytes. Expression primary chondrocytes was assessed by qRT-PCR Western blot. The functionality channel...
Interleukin-6 (IL-6) is involved in the pathogenesis of various inflammatory diseases, like rheumatoid arthritis (RA). In present study, we investigated role IL-6 osteoarthritis (OA) patients and effects stilbenoids monomethyl pinosylvin on expression cartilage matrix components aggrecan collagen II cytokine human OA chondrocytes. Synovial fluid plasma samples were obtained from 100 with severe [BMI 29.7 (8.3) kg/m2, age 72 (14) years, median (IQR); 62/38 females/males] undergoing total knee...
Transient receptor potential (TRP) ion channels are expressed in neuronal and some non-neuronal cells involved particularly pain thermosensation. We previously showed that TRPA1 is functionally human osteoarthritic (OA) chondrocytes mediates inflammation, cartilage degradation, monosodium-iodoacetate-induced experimental OA. In the present study, we explored expression of TRP-channels primary OA investigated whether drugs used treatment OA, ibuprofen glucocorticoids, have effects on...
Background and purpose: The aim of this study was to investigate the levels three adipocytokines: leptin, adiponectin adipsin, in serum cerebrospinal fluid (CSF) twins discordant for multiple sclerosis (MS). Adipose tissue is an important component connecting immune system several tissues organs including CNS. Fat cells produce adipocytokines, which seem have a role various autoimmune disorders MS. Methods: Plasma samples were collected from twelve CSF four concentrations interleukine...
Adipokines are protein mediators secreted by adipose tissue. Recently, adipokines have also been involved in the regulation of inflammation and allergic responses, suggested to affect risk asthma especially obese female patients. We assessed if predict responsiveness glucocorticoids plasma adipokine levels associated with lung function or inflammatory activity non-obese (body mass index (BMI) ≤ 30 kg/m2) women newly-diagnosed steroid-naïve asthma.Lung function, exhaled NO, leptin, resistin,...
3',5'-Cyclic nucleotide PDE4 is expressed in several inflammatory and immune cells, catalyses the hydrolysis of cAMP to 5'AMP, down-regulating signalling cells. MAPK phosphatase-1 (MKP-1) an endogenous p38 suppressor limits gene expression inflammation. In present study, we investigated effect a inhibitor rolipram on MKP-1 whether involved anti-inflammatory effects rolipram.The TNF production was J774 mouse macrophage cell line primary peritoneal macrophages (PM) from wild-type (WT)...
COPD (chronic obstructive pulmonary disease) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, adipose tissue mediated inflammation has gathered increasing interest in the pathogenesis of disease. In this study, we investigated role novel adipocytokines nesfatin-1 visfatin measuring if they are associated with inflammatory activity, function, or symptoms. Plasma levels NUCB2/nesfatin-1 were measured together IL-6, IL-8, TNF- α , MMP-9, exhaled...
Running a marathon causes strenuous joint loading and increased energy expenditure. Adipokines regulate metabolism, but recent studies have indicated that they also exert role in cartilage degradation arthritis. Our aim was to investigate the effects of running on levels adipokines indices metabolism. Blood samples were obtained from 46 male marathoners before after run. We measured matrix metalloproteinase-3 (MMP-3), oligomeric protein (COMP) chitinase 3-like 1 (YKL-40) as biomarkers...
Inducible prostaglandin synthase (cyclooxygenase-2, COX-2) is expressed in rheumatoid and osteoarthritic cartilage produces high amounts of proinflammatory prostanoids the joint. In present study we investigated effects inhibitors mitogen-activated protein kinase (MAPK) pathways Erk1/2, p38, JNK on COX-2 expression E2 (PGE2) production human chondrocytes. Proinflammatory cytokine IL-1beta caused a transient activation immortalized T/C28a2 chondrocytes that was followed by enhanced PGE2...