Kerstin Puchinger
A5063894204- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Biosensors and Analytical Detection
LMU Klinikum
2021-2023
Ludwig-Maximilians-Universität München
2020-2023
Institut für Mikrobiologie der Bundeswehr
2021
Roche Pharma AG (Germany)
2021
German Center for Infection Research
2021
Universität der Bundeswehr München
2021
Helmholtz Zentrum München
2021
Quantitative serological assays detecting response to SARS-CoV-2 are needed quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 in oligo-/asymptomatic individuals from a population-based cohort.In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, 143 positive serology without confirmation by RT-PCR) were tested (Euroimmun Anti-SARS-CoV-2 QuantiVac...
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates magnitude pandemic. We therefore aimed to assess sero-prevalence in Munich general population after first wave For this purpose, we drew a representative sample 2994 private households and invited household members 14 years older complete questionnaires blood samples. seropositivity was defined as Roche N pan-Ig ≥ 0.4218. adjusted prevalence for sampling design,...
Abstract Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components early immune response protect against development severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis nasopharyngeal peripheral blood samples obtained during acute phase infection with SARS-CoV-2. We find that soluble transcriptional markers systemic inflammation peak first week after symptom onset correlate directly upper airways viral...
The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological associated with successful containment in upper airways remains unclear. Here, we combine a multi-omics approach longitudinal sampling reveal temporally resolved signatures non-pneumonic ambulatory infected patients associate specific trajectories airway containment. We see distinct systemic rather than local state containment,...
Abstract Background In the 2nd year of COVID-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding acute long-term virological immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May December 2020 in Munich, Germany, followed up at multiple defined timepoints to one year. viral culture performed seroresponses measured. Participants classified applying the WHO clinical scale. Short symptom test time (median 5.0 days; p = 0.0016) high loads (VL;...
Measuring specific anti-SARS-CoV-2 antibodies has become one of the main epidemiological tools to survey ongoing SARS-CoV-2 pandemic, but also vaccination response. The WHO made available a set well-characterized samples derived from recovered individuals allow normalization between different quantitative anti-Spike assays defined Binding Antibody Units (BAU).To assess sero-responses longitudinally, cohort ninety-nine RT-PCR positive subjects was followed up together with forty-five...
Abstract Background In the 2 nd year of Covid-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Background: Population-based studies investigating the dynamics of SARS-CoV-2 pandemic are needed. Here, we report on baseline findings from April through June 2020 a prospective cohort study in Munich, Germany.Methods: We drew representative sample 2994 private households. The 5313 participating household members 14 years and older completed questionnaires provided blood samples. seropositivity was defined as Roche N pan-Ig ≥ 0·4218. adjusted prevalence for sampling design, sensitivity,...
<title>Abstract</title> Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components early immune response protect against development severe COVID-19. To address this issue, we performed a comprehensive immunogenetic and virologic analysis nasopharyngeal peripheral blood samples obtained during acute phase infection with SARS-CoV-2. We found that soluble transcriptional markers systemic inflammation peaked first week after symptom onset...