A5067139791- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Imaging and Diagnostics
- Autism Spectrum Disorder Research
- Vector-Borne Animal Diseases
- Ultrasound and Hyperthermia Applications
- Virus-based gene therapy research
- Viral Infections and Vectors
- Healthcare and Venom Research
- Vector-borne infectious diseases
- Thermal Regulation in Medicine
- Animal testing and alternatives
- Veterinary Pharmacology and Anesthesia
- Intensive Care Unit Cognitive Disorders
- Advanced X-ray and CT Imaging
- Nail Diseases and Treatments
- Parasitic Infections and Diagnostics
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neuropharmacology Research
- Wildlife Ecology and Conservation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Biology Techniques and Applications
- Primate Behavior and Ecology
- Invertebrate Immune Response Mechanisms
- Microbial Inactivation Methods
Incyte (United States)
2025
Jena University Hospital
2021-2024
University of Göttingen
2013-2019
University of California, San Francisco
2010
University of California, Berkeley
1999-2009
International Union for Conservation of Nature (United States)
2008
California Department of Public Health
2008
Virginia–Maryland College of Veterinary Medicine
1989-1990
Virginia Tech
1989-1990
University of California, Davis
1988
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, long-term cognitive dysfunction. We identified microglia C1q complement activation in hippocampal autopsy tissue patients with increased C1q-mediated synaptic pruning murine polymicrobial model. Unbiased transcriptomics isolated derived from septic mice revealed an involvement the innate immune system, activation, up-regulation lysosomal pathways during SAE parallel to neuronal...
Sepsis-associated encephalopathy (SAE) is a frequent complication of severe systemic infection resulting in delirium, premature death, and long-term cognitive impairment. We closely mimicked SAE murine peritoneal contamination (PCI) model. found long-lasting synaptic pathology the hippocampus including defective plasticity, reduction mature neuronal dendritic spines, severely affected excitatory neurotransmission. Genes related to signaling, gene for activity-regulated...
We investigated the role of western gray squirrel (Sciurus griseus) as a reservoir host Lyme disease spirochete Borrelia burgdorferi. A survey 222 squirrels in California showed an overall prevalence B. burgdorferi infection 30%, although at county level, ranged from 0% to 50% by polymerase chain reaction. Laboratory trials with wild-caught indicated that were competent hosts bacterium and infected up 86% feeding Ixodes pacificus larvae. Infections long-lasting (up 14 months), which...
Abstract Background Immunoglobulin replacement therapy (IgRT) is the current standard of care for primary antibody deficiency patients (majority all immunodeficiency (PID) diseases), with growing real-world evidence supporting use secondary (SID) patients. Infusion methods and practices can affect patients’ satisfaction their treatment perception health-related quality life. Methods An online survey US PID SID was conducted. This research investigates primarily impact two IgRT infusion...
The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric "classical" Epo receptors, alternative receptors are involved in neuroprotection. However, their identity remains enigmatic due complex ligand receptor interactions conflicting experimental results. Besides the classical receptor, family type I also includes poorly characterized...
The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of eumetazoan nervous system. Human CRLF3 belongs to class I helical receptors that mediate pleiotropic cellular reactions injury diverse physiological challenges. It is expressed various tissues including central system but its ligand remains unidentified. A ortholog holometabolous beetle Tribolium castaneum recently shown induce...
The genome of Drosophila melanogaster includes homologs to approximately one third the currently known human disease genes. Flies and humans share many biological processes, including principles information processing by excitable neurons, synaptic transmission chemical signals involved in intercellular communication. Studies on molecular behavioural impact genetic risk factors neuro-developmental disorders (autism spectrum disorders, schizophrenia, attention deficit hyperactivity Tourette...
Microglia are innate immune cells in the brain and show exceptional heterogeneity. They key players physiological development regulating synaptic plasticity shaping neuronal networks. In pathological disease states, microglia-induced pruning mediates loss targeting microglia was proposed as a promising therapeutic strategy. However, effect of depletion subsequent repopulation on dendritic spine density function adult is largely unknown. this study, we investigated whether pharmacological...
The utility of myocardial imaging and assessment regional metabolism omega-(123I-paraphenyl-)pentadecanoic acid (I-PPA) by means serial single-photon tomography is demonstrated in animal experiments. High quality cross sectional images dog hearts with clear delineation left ventricular walls are obtained. Myocardial infarcts visualized as areas deficient radioactivity uptake. I-PPA elimination from non-infarcted regions significantly (p less than 0.001) prolonged when compared unaffected...
In comparison to bulk sequencing or single cell sequencing, spatial transcriptomics preserves the information in tissue slices and can even be mapped immunofluorescent stainings, allowing translation of gene expression into their context. This enables unravel complex interactions neighboring cells link morphology transcriptome data. The 10× Genomics Visium platform offers combine with staining cryo-sectioned slices. We applied this technique fresh frozen mouse brain developed a protocol that...
Commonly applied genotyping of transgenic mice involves using tail or ear biopsies which may cause discomfort to the animal. We tested possibility polymerase chain reaction (PCR)‐based mouse stool specimens from three lines that overexpress 10–18 transgene copies human keratin polypeptide 18, as compared biopsies. Stool were obtained with ease and provided easy detection product. The method was also able detect endogenous actin genes presumably are present at two each. Nested PCR not...
A serological study of antibodies to Ehrlichia risticii was carried out on 10 species wild and domestic mammals found or near 21 horse farms in an area the USA which Potomac fever is endemic. No were 133 peridomestic rodents (Norway rats house mice), nor 108 (white-footed mice meadow voles) captured farms. Three six animal examined, cats, pigs a goat, showed evidence exposure E risticii. Seropositive animals detected three premises. The eight seropositive cats (of 48 tested) two farms, 14...