A5010173108- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Immune cells in cancer
- Mast cells and histamine
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Diet and metabolism studies
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Barrier Structure and Function Studies
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
Goethe University Frankfurt
2021-2024
Saarland University
2021
Next to their role in IgE-mediated allergic diseases and promoting inflammation, mast cells also have antiinflammatory functions. They release pro- as well mediators, depending on the biological setting. Here we aimed better understand of during resolution phase a local inflammation induced with Toll-like receptor (TLR)-2 agonist zymosan. Multiple sequential immunohistology combined statistical neighborhood analysis showed that are located predominantly microenvironment cell-deficiency...
Non-alcoholic steatohepatitis (NASH) and alcoholic (ASH) are the leading causes of liver disease worldwide. To identify disease-specific pathomechanisms, we analyzed lipidome, metabolome immune cell recruitment in livers both diseases. Mice harboring ASH or NASH had comparable severities regarding mortality rate, neurological behavior, expression fibrosis marker albumin levels. Lipid droplet size was higher than qualitative differences lipidome were mainly based on incorporation...
Ischemic stroke is a highly prevalent vascular disease leading to oxygen- and glucose deprivation in the brain. In response, ischemia-induced neovascularization occurs, which supported by circulating CD34+ endothelial progenitor cells. Here, we used transient middle cerebral artery occlusion (tMCAO) mouse model characterize spatio-temporal alterations within ischemic core from acute chronic phase using multiple-epitope-ligand cartography (MELC) for sequential immunohistochemistry. We found...
Article21 December 2022Open Access Source DataTransparent process Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation Anja Kolbinger orcid.org/0000-0003-3120-7277 Institute of Clinical Pharmacology, Goethe-University Frankfurt, Germany Contribution: Investigation, Visualization, Writing - review & editing Search for more papers by this author Tim J Schäufele Hanna Steigerwald orcid.org/0000-0002-4219-6270 Joschua Friedel...
Extracellular vesicles (EVs) secreted by cancer cells have been shown to take a pivotal part in the process of local and systemic tumor progression promoting formation supportive microenvironment preparing premetastatic niches distant organ systems. In this study, we analyzed organ-specific uptake EVs urological using an innovative in-vivo approach. from benign malignant prostate, kidney, bladder were isolated ultracentrifugation, fluorescence-labeled injected intravenously immunodeficient...
Introduction During an innate inflammation, immune cells form distinct pro- and anti-inflammatory regions around pathogen-containing core-regions. Mast are localized in microenvironment during the resolution of suggesting antiinflammatory roles these cells. Methods High-content imaging was used to investigated mast cell-dependent changes regional distribution induced by toll-like receptor (TLR)-2 agonist zymosan. Results The distance between zymosan-containing core-region region, described...
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely prescribed in world due to their analgesic, antipyretic and effects. However, NSAIDs inhibit prostanoid synthesis, interfering with pro-inflammatory functions potentially prolonging acute inflammation.