Jiaojiao Chen

ORCID: 0000-0003-3137-2571
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Research Areas
  • Catalytic Processes in Materials Science
  • Catalysis and Oxidation Reactions
  • ZnO doping and properties
  • Gas Sensing Nanomaterials and Sensors
  • Advanced Photocatalysis Techniques
  • Copper-based nanomaterials and applications
  • Graphene research and applications
  • Nanocluster Synthesis and Applications
  • Advanced biosensing and bioanalysis techniques
  • Receptor Mechanisms and Signaling
  • Nanomaterials for catalytic reactions
  • Ammonia Synthesis and Nitrogen Reduction
  • Quantum Dots Synthesis And Properties
  • Advanced Chemical Physics Studies
  • X-ray Diffraction in Crystallography
  • Hydrogels: synthesis, properties, applications
  • Nanoparticle-Based Drug Delivery
  • Analytical chemistry methods development
  • Inorganic Chemistry and Materials
  • Pesticide Residue Analysis and Safety
  • Boron and Carbon Nanomaterials Research
  • Molecular Sensors and Ion Detection
  • Ga2O3 and related materials
  • Autophagy in Disease and Therapy
  • Electrochemical Analysis and Applications

Shenyang University of Chemical Technology
2023-2025

Zhangjiakou Academy of Agricultural Sciences
2021-2025

Inner Mongolia University of Science and Technology
2025

Jiangsu University
2024-2025

First People's Hospital of Chongqing
2024

Hubei University of Chinese Medicine
2020-2024

Chongqing Public Health Medical Center
2024

Chongqing Medical University
2024

Yuhuangding Hospital
2019-2024

Chinese Academy of Sciences
2017-2023

Abstract Objective Hepatocellular carcinima is one of the most common tumors in clinic and also leading causes death from cancer worldwide. Quercetin shows significant effects on blocking development various cancers. Methods We used human hepatocellular carcinoma LM3 nude mice tumor model to assess quercetin clarify its mechanism action. collected cell line treated with different doses at time periods determined vital indexes. The liver tissues were for western boltting (WB), Hematoxylin...

10.1002/cam4.2388 article EN cc-by Cancer Medicine 2019-07-05

Cleavage of the triple N≡N bond by metal clusters is fundamental interest and practical importance in nitrogen fixation. Previous studies cleavage gas-phase emphasized dinuclear centers. Herein, dissociative adsorption N2 subsequent C-N coupling on trinuclear carbide cluster anions V3C4- under thermal collision conditions have been characterized employing mass spectrometry (collision induced dissociation), cryogenic photoelectron imaging spectroscopy, quantum chemistry calculations. A...

10.1021/jacs.0c02021 article EN Journal of the American Chemical Society 2020-05-25

Shikonin is a natural product with many activities, including anti-cancer effects. Pyruvate kinase type M2 (PKM2) plays crucial role in the growth of tumor cells. However, effect shikonin on PKM2 hepatocellular carcinoma (HCC) unclear.Cell viability, apoptosis level, glucose uptake, and lactate production were detected HCC Lentivirus-overexpressed -shRNA used to verify key target shikonin. A xenograft mouse model was detect efficacy its combination sorafenib vivo.Shikonin inhibited...

10.2147/jhc.s237614 article EN cc-by-nc Journal of Hepatocellular Carcinoma 2020-02-01

Oxide supported gold catalysts (e.g., Au/TiO2) are of great significance in heterogeneous catalysis owing to their extraordinary catalytic activity. Study heteronuclear metal oxide clusters (HMOCs, e.g., AuxTiyOzq) is an important way uncover the molecular-level mechanisms related systems. However, current studies HMOCs focused on charged with little attention paid neutral species. The reactivity study vital have a comprehensive understanding catalysis, but it experimentally challenging...

10.1021/jacs.8b11118 article EN Journal of the American Chemical Society 2018-12-29

Hepatic ischemia reperfusion (IR) injury (IRI) occurs during liver transplantation, hepatectomy, and hemorrhagic shock. Oleanolic acid (OA) is a natural compound with antioxidant anti-inflammatory activity that has been used to treat disorders in clinical practice for several years. Here, we investigated the effects underlying mechanisms of OA hepatic IRI. A 60-minute partial (70%) hepatic, warm, ischemic model was established BALB/c mice, two doses (30 60 mg/kg) were administered...

10.1155/2019/3240713 article EN cc-by Mediators of Inflammation 2019-06-18

The electronic structure of two-dimensional (2D) materials in van der Waals heterojunctions also appears extensive theoretical research, we use DFT-D2 theory to calculate the energy band, density states, formation energy, work function, charge difference, optical properties, and our calculations show that there is no electrons holes redistribution at intrinsic ZnO composite graphene interface, vacancy defects doping not only make electron–hole good separation, but a significant increase UV...

10.1016/j.egyr.2021.12.016 article EN cc-by-nc-nd Energy Reports 2021-12-24

Catalytic conversion of toxic nitrogen oxide (NO) and carbon monoxide (CO) into (N2) dioxide (CO2) is imperative under the weight increasingly stringent emission regulations, while a fundamental understanding nature active site to selectively drive N2 generation elusive. Herein, in combination with state-of-the-art mass-spectrometric experiments quantum-chemical calculations, we demonstrated that rhodium-cerium clusters RhCe2O3-5- can catalytically NO reduction by CO give rise CO2. This...

10.1021/jacs.3c06565 article EN Journal of the American Chemical Society 2023-08-12

Salvianolic acid A (SAA), an important bioactive polyphenolic found in Salvia miltiorrhiza Bunge, may be used for treating metabolic disorders due to its anti-inflammatory activity. Since chronic inflammation plays role type 2 diabetes mellitus (T2DM) complicated with atherosclerosis (AS), SAA have beneficial effects on AS. Here, we evaluated the of male Zucker diabetic fatty (ZDF) rats induced by a high-fat diet and Vitamin D3 injections. Compared model group, high dosage (1 mg/kg) group...

10.3390/molecules25051089 article EN cc-by Molecules 2020-02-28

Aflatoxin B1 (AFB1) is highly toxic and challenging to remove, posing significant risks both human health economic development. Therefore, there an urgent need develop rapid, simple, sensitive detection technologies. In this study, we introduce a naked-eye colorimetric method based on multiple isothermal amplifications coupled with CRISPR–Cas14a investigate its biosensing properties. This technique utilizes composite nanoprobes (MAPs) comprising magnetic nanoparticles gold nanoparticles....

10.1021/acsami.3c13331 article EN ACS Applied Materials & Interfaces 2023-11-28

Pectate lyase (PL) holds significant potential for applications in various industries. However, the existing PL was unable to adapt thermo-alkaline industrial environments. In this work, a from Caldicellulosiruptor bescii DSM 6725 (hereafter, CbPelD) studied disclose its structural and biochemical properties. CbPelD consisted of putative signal peptide sequence, short linker region, catalytic domain (PelD-II), along with an exoacting β-fructofuranosidase (PelD-I). molecular dynamics...

10.1021/acs.jafc.4c12214 article EN Journal of Agricultural and Food Chemistry 2025-03-04
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