- Neuroscience and Neuropharmacology Research
- Proteoglycans and glycosaminoglycans research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Glycosylation and Glycoproteins Research
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Chemical Sensor Technologies
- Virus-based gene therapy research
- Caveolin-1 and cellular processes
- Bacteriophages and microbial interactions
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Heart Rate Variability and Autonomic Control
- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- Neurobiology and Insect Physiology Research
- Eicosanoids and Hypertension Pharmacology
University of Oslo
2016-2025
Beth Israel Deaconess Medical Center
2020-2025
Harvard University
2020-2025
Abstract Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons. It has been suggested PNNs stabilize synaptic connections long-term memories, but their role the cell remains elusive. We show removal leads to lower spiking activity, reduces cells’ ability create stable representations novel...
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end period heightened visual cortex plasticity in juveniles, whereas removal adults reopens for plasticity. mechanisms underlying this phenomenon remain elusive. We have used chronic electrophysiological recordings to investigate accompanying changes activity-dependent and we report on novel involved both induced critical By...
In the adult brain, extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan core component condensed ECM structures termed perineuronal nets (PNNs), specific role PNNs on neural plasticity remains elusive. Here, we genetically targeted Acan gene encoding for using novel animal model. This allowed conditional loss vivo , which ablated PNN structure caused shift...
Significance Perineuronal nets (PNNs), a type of extracellular matrix only found in the central nervous system, wraps tightly around cell soma and proximal dendrites subset neurons. The PNNs are long-lasting structures that restrict plasticity, making them eligible candidates for memory processing. This work demonstrates lateral secondary visual cortex (V2L) essential recall remote fear memory. results suggest role molecules storage retrieval memories.
Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that condense around the soma and proximal dendrites of subpopulations neurons. Emerging evidence suggests they involved in regulating brain plasticity. However, expression PNNs varies between within areas. A lack quantitative studies describing distribution cell-specificity makes it difficult to reveal functional roles PNNs. In current study, we examine identity PNN-enwrapped neurons three areas with different...
Genetically encoded Ca
Abstract Perineuronal nets (PNNs) are a condensed form of extracellular matrix primarily found around parvalbumin-expressing (PV+) interneurons. The postnatal maturation PV+ neurons is accompanied with the formation PNNs and reduced plasticity. Alterations in PNN neuron function have been described for mental disorders such as schizophrenia autism. highly dependent on aggrecan, proteoglycan encoded by ACAN gene, but it remains unknown if produced themselves. Thus, we established knockout...
Abstract The transition from juvenile to adult is accompanied by the maturation of inhibitory parvalbumin-positive (PV+) neurons and reduced plasticity. This involves formation perineuronal nets (PNNs), a dense configuration extracellular matrix that predominantly envelops neurons. Aggrecan, proteoglycan encoded ACAN gene, has been shown have key role in PNNs as knock-out brain reactivates plasticity, but contribution different cell populations unknown Here, we establish characterize mouse...
The medial entorhinal cortex (MEC) is pivotal in spatial computations and episodic memory. In particular, an animal’s position can be decoded from the activity of grid cells. However, it remains elusive whether MEC could play a more general role different types associative learning how representations develop during process. It has been shown that postrhinal (POR), which directly connected to MEC, integrates visual stimuli with salient outcomes. Here, we use non-spatial association task...
The medial entorhinal cortex (MEC) is pivotal in spatial computations and episodic memory. In particular, an animal’s position can be decoded from the activity of grid cells. However, it remains elusive whether MEC could play a more general role different types associative learning how representations develop during process. It has been shown that postrhinal (POR), which directly connected to MEC, integrates visual stimuli with salient outcomes. Here, we use non-spatial association task...
Abstract Studies of body-to-brain communication often examine one stimulus or organ at a time, yet the brain must integrate many body signals during behavior. For example, food consumption generates diverse oral and post-oral chemical mechanical transduced by well-characterized peripheral neuronal pathways. Far less is known about how these other bodily are integrated organized in brainstem lateral parabrachial nucleus (LPBN), key interoceptive sensory hub. We established methods to image...
Highly salient events activate neurons across various brain regions. During subsequent rest or sleep, the activity patterns of these often correlate with those observed during preceding experience. Growing evidence suggests that reactivations play a crucial role in memory consolidation, process by which experiences are solidified cortical networks for long-term storage. Here, we use longitudinal two-photon Ca 2+ imaging alongside paired LFP recordings hippocampus and cortex, to show targeted...
Spatial code of grid cells is independent theta oscillations and phase precession.
ABSTRACT Calcium imaging using genetically encoded Ca 2+ indicators (GECIs) is a widely adopted method to measure neural activity in modern neuroscience. Here, we explore the use of systemically administered viral vectors for brain-wide expression GECIs, and adapt novel GECIs optimize signal-to-noise. We show that systemic injections PHP.eB AAVs express highly promising technique circumvent need transgenic GECI expressing mouse lines. also establish soma-targeted outperform current both...
Abstract Grid cells are part of a widespread network that supports navigation and spatial memory. Stable grid patterns appear late in development, concert with extracellular matrix aggregates termed perineuronal nets (PNNs) condense around inhibitory neurons. To reveal the relationship between stable representations presence PNNs we recorded from populations neurons adult rats. We show removal leads to lower spiking activity, reduces cells’ ability create novel environment. Furthermore,...
Abstract Highly salient events activate neurons across various brain regions. During subsequent rest or sleep, the activity patterns of these often correlate with those observed during preceding experience. Growing evidence suggests that reactivations play a crucial role in memory consolidation, process by which experiences are solidified cortical networks for long-term storage. Here, we demonstrate lateral visual cortex vital consolidation association learning. By employing longitudinal...
Abstract The medial entorhinal cortex (MEC) is pivotal in spatial computations and episodic memory. In particular, an animal’s position can be decoded from the activity of grid cells. However, it remains elusive whether MEC could play a more general role different types associative learning how representations develop during process. It has been shown that postrhinal (POR), which directly connected to MEC, integrates visual stimuli with salient outcomes. Here, we use non-spatial association...