A5003168483- Cutaneous lymphoproliferative disorders research
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- FOXO transcription factor regulation
- Clostridium difficile and Clostridium perfringens research
- Connective tissue disorders research
- RNA modifications and cancer
- Phytochemical compounds biological activities
- Pneumonia and Respiratory Infections
- T-cell and Retrovirus Studies
- 14-3-3 protein interactions
- Congenital Ear and Nasal Anomalies
- Genetics and Neurodevelopmental Disorders
- Hemoglobinopathies and Related Disorders
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Muscle Physiology and Disorders
- Neonatal Health and Biochemistry
- Neurogenetic and Muscular Disorders Research
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- Trypanosoma species research and implications
- Plant and Fungal Interactions Research
- Nosocomial Infections in ICU
- Cardiovascular Issues in Pregnancy
Hamad Medical Corporation
2020-2025
Quaid-i-Azam University
2013-2018
Infectious Disease Research Institute
2008
The tumor microenvironment (TME) exerts a profound influence on the oncogenesis and progression of various cancers, notably those instigated by human papillomavirus (HPV) Epstein-Barr virus (EBV). etiology HPV EBV-associated malignancies is rooted in intricate interactions that intertwine viral infections, genetic predispositions, distinct TME dynamics. These foster milieu can either support or hinder tumorigenic progression. Gaining in-depth knowledge TME's unique features, including its...
Human papillomavirus (HPV) has been implicated in the etiology of a variety human cancers. Studies investigating presence high-risk (HR) HPV breast tissue have generated considerable controversy over its role as potential risk factor for cancer (BC). This is first investigation reporting prevalence and type distribution infection population Qatar. A prospective comparison blind research study herein reconnoitered twelve HR-HPV types’ DNA using multiplex PCR by screening total 150 fresh...
Background/Objectives: Arterial Tortuosity Syndrome (ATS) is a rare, autosomal recessive connective tissue disorder characterized by arterial twists, abnormal bulges, constriction, and tears. Patients have distinctive features disease manifestations. The syndrome's full clinical spectrum course remain incompletely understood. Methods: We sought to review the medical records of Qatari patients who had ATS. cohort study included 21 were genetically confirmed mutations in SLC2A10 gene. Results:...
Abstract The advent of personalised medicine promises a deeper understanding mechanisms and therefore therapies. However, the connection between genomic sequences clinical treatments is often unclear. We studied 50 breast cancer patients belonging to population-cohort in state Qatar. From Sanger sequencing, we identified several new deleterious mutations estrogen receptor 1 gene (ESR1). effect these on drug treatment protein target encoded by ESR1, namely receptor, was achieved via rapid...
Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development progression several cancers, including chronic myelogenous leukemia (CML). However, molecular mechanism FOXM1/BUB1B regulatory network role Neosetophomone-B (NSP-B) in remains unclear. NSP-B, a meroterpenoid fungal secondary metabolite, possesses anticancer potential human leukemic cells lines; however, underlying has not been...
Nitazoxanide has been proven to be efficacious for the treatment of Clostridium difficile infection (CDI), but data is limited in peritoneal dialysis (PD) patients. This report details successful utilization nitazoxanide and probiotics treat multirecurrent CDI a PD patient. A 58-year-old woman was admitted with hypotension, nausea vomiting attributed metronidazole therapy CDI, her third regimen 3 months. During admission, patient developed started on 6-week assist re-establishing colonic...
Two inherited unconjugated hyperbilirubinemias, Crigler-Najjar syndrome and Gilbert syndrome, arise due to deficiency of UGT1A1 enzyme activity. type 1 (CN1) lies at the extreme severe end spectrum activity characterized by complete absence, followed less 2 (CN2). is mild form having only partial loss The present study aimed identify molecular genetic defects underlying hyperbilirubinemias in children from six consanguineous Pakistani families. patients were clinically diagnosed exclusion...
Abstract The aim of the current study is to review molecular characteristics Neisseria meningitidis ( N. ) in Hamad Medical Corporation, which provider secondary and tertiary care state Qatar. A total 39 isolates from period 2013 2018 were revived identified by Vitek, susceptibility on basis E test was retrieved patient’s files. subjected multilocus sequence typing. most common serogroup (19) W135, 12 isolated blood CSF. ST-11 predominant ST clonal complex causing cases (61.53%). Clonal...
Background: Mucolipidosis III gamma (MLIIIγ) is a rare autosomal recessive disorder characterized by radiographic evidence of mild-to-moderate dysostosis multiplex, progressive joint stiffness and pain, scoliosis, normal to mildly impaired cognitive development. Cardiac valve involvement respiratory complications can be significant. MLIIIγ caused mutations in the GNPTG, which encodes γ subunit enzyme N-acetylglucosamine-1-phosphotransferase. Objective: Clinical genetic study seven...
Background: Escobar syndrome, a nonlethal variant of multiple pterygium syndromes (MPS), is rare autosomal recessive disorder characterized by pterygia and joint contractures along with other anomalies. Variants in cholinergic receptor nicotinic gamma subunit (CHRNG) have been previously reported patients syndrome. Objective: We studied consanguineous Pakistani family affected syndrome to identify the underlying genetic defect through short tandem repeat (STR) genotyping direct DNA...
IntroductionThe etiology and pathogenesis of acrodermatitis continua Hallopeau (ACH), a form localized pustular psoriasis, remain poorly understood.1Navarini A.A. Burden A.D. Capon F. et al.European consensus statement on phenotypes psoriasis.J Eur Acad Dermatol Venereol. 2017; 31: 1792-1799https://doi.org/10.1111/jdv.14386Crossref PubMed Scopus (147) Google Scholar Despite the availability several treatment options, patients with ACH often have an insufficient response to therapy. No...
Cutaneous T cell lymphoma (CTCL) is a varied group of neoplasms that affects the skin. Acquired resistance against chemotherapeutic drugs and associated toxic side effects are limitations warrant search for novel CTCL. Embelin (EMB) naturally occurring benzoquinone derivative has gained attention owing to its anticancer pharmacological actions nontoxic nature. We assessed activity EMB CTCL lines, HuT78, H9. inhibited viability cells in dose-dependent manner. activated extrinsic intrinsic...
Purpose:Clostridium difficile infection (CDI) is a significant problem which increasing in incidence and severity hospitalized patients. While reported vitro resistance to metronidazole (MTZ) vancomycin (VAN) relatively nonexistent, clinical outcomes with these drugs have been less than desirable (Clin Infect Dis 2005;40:1586–90, Clin 2006;43:421–7). Furthermore, the concern of possible selection for VAN has created need alternative antibiotic therapies CDI. Nitazoxanide (NTZ) first class...
Background: The advent of personalised medicine promises a deeper understanding mechanisms and therefore therapies. However, the connection between genomic sequences clinical treatments is often unclear. Methods: We studied 50 breast cancer patients belonging to population-cohort in state Qatar. effect these mutations on drug treatment protein target encoded by ESR1, namely estrogen receptor, was achieved via rapid accurate protein-ligand binding affinity interaction studies which were...