We investigated the potential hepatoprotective effects of misoprostol (MP) on doxorubicin (DOX) induced liver injury in rats using histology and biochemistry. used 21 male Sprague-Dawley divided randomly into three groups: group 1, control; 2, DOX; 3, DOX + MP. The control was injected intraperitoneally (i.p.) with 0.5 ml 0.9% w/v NaCl given 1 orally for 6 days. administered i.p. as a single dose 20 mg/kg. MP, 0.2 mg/kg, Treatment MP increased high density lipoprotein cholesterol levels...

Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown that silibinin inhibits experimentally induced malignancies of the liver, prostate, skin, colon well promotes inhibition proliferation cancer cell lines in vitro. This study aimed to investigate effects on human breast carcinoma MDA-MB-231 MCF-7 monolayer spheroid cultures.The were cultured both...

We investigated the potential neuroprotective effects of thymoquinone (TQ) on amikacin (AK) induced oxidative damage in rat brain. used 21 male rats divided randomly into three equal groups. The control group was injected intraperitoneally (i.p.) with 0.5 ml 0.9% aqueous NaCl and given 1 orally. AK administered 1.2 g/kg i.p. as a single dose day 3 study. + TQ study plus 40 mg/kg/day by oral gavage daily. Treatment increased serum ferritin decreased calcium levels significantly. also NADPH...

We investigated the potential cardioprotective effects of misoprostol (MP) on doxorubicin (DOX) induced cardiac damage using histologic and biochemical assessment rat heart. used 21 male rats divided randomly into three groups: group 1, control; 2, DOX; 3, DOX + MP. The control was given 0.5 ml 0.9% NaCl intraperitoneally (i.p.) 1 orally for 6 days. administered as a single dose 20 mg/kg i.p. day 3. MP found that treatment with decreased significantly serum troponin-I, brain natriuretic...

This study sought to assess the protective effects of resveratrol and avocado oil in relation paracetamol-induced hepatotoxicity rats. The rats were divided into five groups, namely control, paracetamol (600 mg/kg), (RES; 10 mg/kg) + paracetamol, (AVO; 200 RES AVO groups. hepatoprotective activity was evaluated by measuring biochemical parameters such as total antioxidant status (TAS) oxidant (TOS) each rat's liver homogenates. Any DNA damage assessed means a comet assay. results showed that...

Apoptotic effects of secoisolariciresinol diglucoside (SDG) in 2D and 3D cultures SW480 cells were investigated. 40–200 μM SDG was used IC50 values determined for three different time intervals as 24, 48, or 72 hr further experiments. BrdU, TUNEL, AIF, caspase-3 stainings used. inhibited cell proliferation almost half all also, induced apoptosis. percentages the control group 27.00%, 29.00%, 28.00%, respectively, while treatment 59.00%, 61.00%, 62.00%, respectively. In spheroid culture,...

This study aimed to investigate the effects of juglone on human bladder carcinoma cell lines TCC-SUB and RT-4 in monolayer spheroid cultures. Cells were treated with at 24, 48, 72 h incubation. The activity caspase-3 was detected vitro using a colorimetric assay kit according manufacturer's instructions. bromodeoxyuridine (BrdU) labeling index used determine cells synthesis phase. terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling death both control group had large S-phase...

Colon cancer is a major cause of morbidity and mortality in the world. Juglone natural compound which has been isolated from Juglans mandshurica Maxim, it various pharmacological effects such as antiviral, antibacterial, anticancer. In our study, we aimed to investigate effect juglone on CCL-228-SW 480 colon carcinoma cell line monolayer spheroid culture medium.The lines were cultured both cultures. Cells treated with at 24, 48, 72 h incubation. ID50 inhibition was determined dose for after...

Aim: In this article, we evaluated the possible cardiac protective effects of silymarin on valproic acid-induced heart injury by histological and biochemical parameters in rat heart.Material Methods: The experiment was performed with 21 Sprague Dawley male rats. Rats were divided into three groups: group 1; control, 2; acid, 3; acid + silymarin. groups received 500 mg/kg/day per os (p.o.) 100 p.o. for 14 days except control group.Results: Silymarin treatment decreased levels lactate...

Being the most commonly used antipyretic and analgesic, paracetamol is one of common causes childhood poisoning in world maintains its importance also our country. Paracetamol liver failure. This study aimed to investigate if pomegranate juice had protective effect acute toxicity related with paracetamol.A total 36 Wistar-Albino rats were divided into four groups as group (3 000 mg/kg paracetamol), + (1.5 mL plus 3 juice) control distilled water). Pomegranate water administered for eight...

Little is known about the pathogenesis of high fructose corn syrup (HFCS) induced hepatic toxicity. We investigated lesions by chronic HFCS consumption and protective effects alpha-lipoic acid (ALA) on liver pathology. used 24 rats allocated randomly into three groups eight. The group was given in drinking water for 10 weeks. ALA + same dose also administered during last 6 weeks experiment. control untreated. were euthanized at end h after administration. A significant increase observed...

Background. This experimental study aimed to assess the effects of Vitamins C and E on orthodontictooth movement. Methods. Fifty-one male Wistar albino rats were divided into six groups: five appliance groups onecontrol group. The had an orthodontic consisting a closed-coil springligated between maxillary incisor first molar (50 g). Vitamin (150 mg/kg)were injected intraperitoneally per day in second groups, respectively. andC (20 μL) locally periodontal gap moving teeth third fourthgroups,...

Quercetin (QCT) is a dietary flavonoid with many beneficial effects (e.g., antioxidant, antiaging, antidiabetic, antifungal effects, and regulation of gastrointestinal motor activity in human); furthermore, it induces apoptosis, cell cycle arrest, differentiation.The apoptotic OCT were investigated on SW480 human colon cancer lines monolayer spheroid cultures.Quercetin (40-200 μM) was applied, Inhibitory Concentration (IC50) doses determined for three time intervals (24, 48, 72 h). The...

Methotrexate is an important immunosuppressive and antineoplastic drug widely used for treatment. However, hepatotoxicity one of the major adverse effects methotrexate. In this study, it was aimed to investigate whether ramelteon has a possible protective effect on induced by Thirty-two Wistar albino rats were equally divided into four groups: control, methotrexate, methotrexate + ramelteon, ramelteon. Following single dose 20 mg/kg, (i.p.), either saline or 10 mg/kg (orally) administered 7...

To investigate the efficiency of Capparis ovata as a protective agent against acute paracetamol toxicity liver.A total 36 Wistar albino rats were divided into 4 groups: 1) paracetamol, 2) + 3) ovata, and 4) control. Groups 2 3 given 1 distilled water for 8 days. On day 8, 3000 mg kg-1 was administered orally to 2. Samples taken on 9. AST, ALT, bilirubin, direct GGT, ALP levels assessed. Lipid peroxidation markers thiobarbituric acid-reactive substance (TBARS) measured in blood liver. Liver...

Methotrexate is an immunosuppressive and antineoplastic drug that may induce hepatotoxicity. Resveratrol a compound has protective effect thanks to its antioxidant role. In present study was aimed investigate posibble effects of resveratrol in methotrexate induced Eighteen Wistar Albino rats were equally divided into three groups: Control, Methotrexate, + Resveratrol. After single dose (15 mg/kg, i.p.), (10 orally) applied for 7 days. Fallowing days, sacrificed. Histopathological (H-E...

Valproic acid (VA), widely used as an antiepileptic, causes structural and functional kidney disorders. Whether thymoquinone (TQ) has a beneficial effect on valproic (VA)-induced nephrotoxicity been investigated. Twenty-one male Spraque Dawley rats were grouped into control, VA, VA + TQ groups (n=7 for per group). (500 mg/kg/day) (50 applied to the orally 14 days. They euthanized 15th day of treatment. The cyclooxygenase 1 (COX-1) 2 (COX-2) gene expression levels, biochemical parameters,...