A5102006473- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Chemical Reactions and Isotopes
- Cancer Genomics and Diagnostics
- Diabetes Management and Research
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Digestive system and related health
- Radiopharmaceutical Chemistry and Applications
- Clinical practice guidelines implementation
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neurogenetic and Muscular Disorders Research
- Ear Surgery and Otitis Media
- Congenital Heart Disease Studies
Rothman Orthopaedics
2024-2025
Indianapolis Zoo
2023
Varian Medical Systems (Switzerland)
2023
Jacksonville College
2020-2023
Mayo Clinic in Florida
2018-2023
St. Jude Children's Research Hospital
2006-2022
Indiana University School of Medicine
2022
Indiana University
2022
University School
2022
WinnMed
2019-2021
A prospective study to determine the lymph node involvement in 33 pancreatectomy specimens (regional 18, total 7, Whipple partial 8) was undertaken. There were 22 patients with pancreas duct adenocarcinoma, 6 ampullary carcinoma, 3 duodenal 1 bile carcinoma and of undetermined site origin. Peripancreatic nodes divided into 5 main groups subgroups. They are 1) Superior, Superior Head, Body Gastric; 2) Inferior: Inferior Head Body, 3) Anterior: Anterior Pancreaticoduodenal, Pyloric Mesenteric,...
The release of mitochondrial intermembrane space proteins to the cytosol is a key event during apoptosis. We used in situ fluorescent labeling tagged with short tetracysteine-containing sequence follow Smac, Omi, adenylate kinase-2, cytochrome c, and apoptosis-inducing factor (AIF) apoptosis compared that c GFP individual cells observed over time. caspase-independent, simultaneous kinase-2. Although AIF also was caspase-independent commenced other proteins, it proceeded much more slowly...
Review of 140 Cases3 I N C E the early work Lubarsch,29 in 1888, a primary tumor gastrointestinal tract has been recognized that is present most commonly appendix, superficially resembles carcinoma upon histological examination, yet distinctive appearance and behavior.Oberndorfer, 1907, used term "carcinoid" for this because his belief neoplasm was benign, despite its resemblance to carcinoma.Masson colleagueslg first noted remarkable affinity silver salts displayed by intracytoplasmic...
Degeneration of pancreatic acinar cells in rats injected with ethionine was studied by electron microscopy. The most conspicuous morphologic lesions occurred the ergastoplasm. There a widening endoplasmic reticulum, decrease number membrane-associated ribosomes, and development fine coarse vacuoles containing agranular disoriented membranes. Cytoplasmic ribosomes unassociated membranes were less numerous. Nuclear changes consisted coarsening clumping nuclear chromatin, chromatin margination,...
The mitochondrial pathway of apoptosis is the major mechanism physiological cell death in vertebrates. In this pathway, proapoptotic members Bcl-2 family cause outer membrane permeabilization (MOMP), allowing release cytochrome c , which interacts with Apaf-1 to trigger caspase activation and apoptosis. Despite conservation Bcl-2, Apaf-1, caspases invertebrate phyla, existence any is, at best, controversial. Here we show that a lophotrochozoan, planaria (phylum Platyhelminthes), associated...
Noncanonical functions of autophagy proteins have been implicated in neurodegenerative conditions, including Alzheimer's disease (AD). The WD domain the protein Atg16L is dispensable for canonical but required its noncanonical functions. Two-year-old mice lacking this presented with robust β-amyloid (Aβ) pathology, tau hyperphosphorylation, reactive microgliosis, pervasive neurodegeneration, and severe behavioral memory deficiencies, consistent human disease. Mechanistically, we found was...
The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)-dependent necroptosis vivo. Here, we show that spontaneous RIPK3, phosphorylation MLKL, Caspase-8- FADD-deficient cells was dependent on the nucleic acid sensor, Z-DNA binding protein-1 (ZBP1). We genetically engineered a mouse model by single insertion FLAG tag onto N terminus endogenous MLKL (
By contract with the National Cancer Institute, accuracy of diagnostic techniques was assessed in 184 patients suspected having pancreas cancer. Of 138 who were operated upon, 89 found to have duct cancer, 30 had cancer a different site origin head region and 19 there no evidence at operation. All 46 not 13 proven 33 discharged as free followed our clinic. The majority presented signs symptoms biliary obstruction. Computerized transaxial tomography (CTT) gave "correct" diagnosis 31 (94%) 2...
After 10 days of a protein-free diet the acinar cells rat pancreas showed coarsening nuclear matrix, depletion zymogen granules, some loss ribosomes, and widening spaces between ergastoplasmic membranes. In addition, there could be found, but rarely, lesion ergastoplasm consisting vacuoles agranular, disoriented membranes, which was similar to produced by ethionine. Thereafter, return toward normal structure occurred characterized beginning increase in size Golgi apparatus at 12 days,...
The regeneration of the pancreatic acinar cell was studied at four time periods after ethionine had destroyed most cells. Within 2 days last injection, small basophilic cells (pre-acinar cells) with whorls ergastoplasm or nebenkern were present. These also contained a decreased amount Golgi substance, zymogen granules, and fine granularity nuclear matrix. They showed persistence characteristic lesion produced by ethionine. Eight replaced approximately normal appearing nucleoli bodies...
A series of 53 cases chronic pancreatic disease is described and attention drawn to the frequency with which symptoms are persistent rather than intermittent. plea made for use term ;progressive' ;relapsing' in describing many these cases. Alcohol was an unimportant factor aetiology. The possibility achieving accurate early diagnosis using serum secretin/pancreozymin test emphasized. frequent relief prevention progress by surgery, especially sphincterotomy, recorded.
IN the six-year period from 1943 to 1949, there have been studied by radioautographic technique at Department of Pathology, Memorial Hospital, and Physics, Sloan-Kettering Institute, New York City, 100 specimens carcinoma thyroid patients who had previously given radioactive iodine (I131). In all cases diagnosis was made histologic sections either hospital or submitted material. The group comprises 94 operative one aspiration biopsy specimen 81 patients, tissue necropsies 5 patients. 89...