A5114376484- Blood groups and transfusion
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Biosensors and Analytical Detection
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Molecular Biology Techniques and Applications
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Blood transfusion and management
- Mycobacterium research and diagnosis
- Platelet Disorders and Treatments
- Cervical Cancer and HPV Research
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Organ Transplantation Techniques and Outcomes
- Bacteriophages and microbial interactions
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
Asan Medical Center
2016-2025
Ulsan College
2014-2025
University of Ulsan
2015-2025
Daegu Gyeongbuk Institute of Science and Technology
2012-2025
Sungkyunkwan University
2025
Korea University Medical Center
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023
ProQuest (United States)
2023
Sangmyung University
2015-2021
Dong-Eui University
2021
New semi-crystalline photovoltaic polymers were synthesized and the optimized device exhibited 9.39% efficiency in a ∼300 nm thick single-cell device.
<h3>Importance</h3> Despite the increased use of rituximab therapy in neuromyelitis optica spectrum disorder (NMOSD), overall efficacy and safety long-term treatment a large group patients is uncertain. Furthermore, identification predictor response an important issue for assessing individual risk-benefit making decisions. <h3>Objective</h3> To assess clinical with NMOSD influence fragment c gamma receptor 3A (<i>FCGR3A</i>) polymorphisms on response. <h3>Design, Setting, Participants</h3> A...
DDX41 mutations are associated with hematologic malignancies including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but the incidence in idiopathic cytopenia of undetermined significance (ICUS) is unknown. We investigated incidence, genetic characteristics, clinical features Korean patients ICUS, MDS, or AML. performed targeted deep sequencing 61 genes 457 ICUS (n=75), MDS (n=210), AML (n=172). Germline causality were identified 28 (6.1%) patients, whom 27 (96.4%) had...
Abstract Background Array comparative genomic hybridization (CGH) is currently the most powerful method for detecting chromosomal alterations in pre and postnatal clinical cases. In this study, we developed a BAC based array CGH analysis platform whole genome DNA copy number changes including specific micro deletion duplication disorders. Additionally, report our experience with implementation of platform. was performed on 5080 samples from patients referred variety phenotypes. Results A...
Passive exposure to tobacco smoke significantly contributes morbidity and mortality in children. Children, particular, seem be the most susceptible population harmful effects of environmental (ETS). Paternal smoking inside home leads significant maternal fetal ETS may subsequently affect health. has been associated with adverse on pediatric health, including preterm birth, intrauterine growth retardation, perinatal mortality, respiratory illness, neurobehavioral problems, decreased...
A colorimetric-fluorescent dual-mode lateral flow immunoassay sensor incorporating metal-enhanced fluorescence (MEF) for the rapid and sensitive serological detection of SARS-CoV-2 IgG was developed.
We evaluated a new immunochromatographic assay (ICA) using mouse monoclonal anti-MPT64 antibody for rapid discrimination between Mycobacterium tuberculosis and nontuberculous mycobacteria in clinical isolates. A study with other organisms showed excellent sensitivity (approximately equal 99%) specificity (100%) an appropriate detection limit (10(5) CFU/ml) when tested M. H37Rv. This ICA can simplify the identification of laboratories.
Biology is generating more data than ever. As a result, there an ever increasing number of publicly available databases that analyse, integrate and summarize the data, providing invaluable resource for biological community. this trend continues, pressing need to organize, catalogue rate these resources, so information they contain can be most effectively exploited. MetaBase (MB) (http://MetaDatabase.Org) community-curated database containing 2000 commonly used databases. Each entry...
Abstract Background: Lung cancer is a leading cause of deaths. Unfortunately, no effective early screening modality exists for lung cancer. We aimed to evaluate the prevalence HOXA9 promoter methylation in tissue and induced sputum samples from Korean patients with Methods: Using pyrosequencing, was analyzed 40 pairs primary normal tissues 185 specimens, including 76 Results: The significantly higher compared (67.4%±17.6% vs. 23.6%±10.3%, respectively; p<0.001). With cut-off >45.6%...
Frequent itemset mining is widely used as a fundamental data technique. However, the size increases, relatively slow performances of existing methods hinder its applicability. Although many sequential frequent have been proposed, there clear limit to performance that can be achieved using single thread. To overcome this limitation, various parallel multi-core CPU, multiple machine, or many-core graphic processing unit (GPU) approaches proposed. these still drawbacks, including performance,...
Human papillomavirus testing by self-sampling and urine sampling might be alternatives to Papanicolaou test (Pap test) for cervical cancer screening (CCS), may increase compliance adherence thereto. The present study aimed explore satisfaction preferences modalities among Korean women.In total, 732 women aged between 20 69 years responded a questionnaire designed survey the women's perceived 3 CCS modalities: clinician-collected Pap test, self-collected vaginal (self-sampling)...
Loop-mediated isothermal amplification (LAMP) is a nucleic acid method that allows the simple, quick, and low-cost detection of various viral genes. LAMP assays are susceptible to generating non-specific amplicons, as high concentrations DNA primers can give rise primer dimerization mismatched hybridizations, resulting in false-positive signals. Herein, we reported poly(ethylene glycol)-engrafted nanosized graphene oxide (PEG-nGO) significantly enhance specificity LAMP, owing its ability...
ABSTRACT Since vancomycin-intermediate Staphylococcus aureus (VISA) was first reported in Japan 1997, there has been great concern that heterogeneous S. (hetero-VISA) is the putative precursor of VISA. To investigate prevalence, clinical significance, and molecular epidemiology with reduced susceptibility to vancomycin, all consecutive isolates isolated from specimens December 1998 August 1999 at Asan Medical Center were screened for VISA hetero-VISA by using brain heart infusion agar...
ABSTRACT We evaluated high-resolution melting (HRM) curve analysis as a tool for detecting rifampin (RIF) and isoniazid (INH) resistance in Mycobacterium tuberculosis an accurate, affordable, rapid manner. Two hundred seventeen M. clinical isolates of known phenotype were used. Twenty-nine rpoB mutant DNAs, including rare mutations, also included. Four pairs primers designed: -F/R (for codons 516 to 539 ), -516F/R 508 536 katG the codon 315 region inhA nucleotide substitution C T at position...
Rapid, simple, and inexpensive diagnostic point-of-care tests (POCTs) are essential for controlling infectious diseases in resource-limited settings. In this study, we developed a new detection system based on nanoparticle-DNA aggregation (STat of tagged DNA, STAT-DNA) to yield visual change that can be easily detected by the naked eye. This simplified optical was applied detect hepatitis C virus (HCV). Reverse transcription-polymerase chain reaction (RT-PCR) performed using primers labeled...
Possible correlations between the expression of immune checkpoint molecules and prognosis in childhood acute leukemia were investigated.The programmed-death 1 (PD1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), B- T-lymphocyte attenuator (BTLA) was determined by flow cytometry on peripheral αβ+ γδ+ T-cells from patients with newly diagnosed lymphoblastic (ALL) (n=9) or myeloid (AML) (n=12), healthy volunteers (n=7). The ligand (PD-L1), B7-1, B7-2, human leukocyte antigen-ABC...
Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the distribution and antimicrobial resistance of S. isolated between 2014 2016 Korea.We collected a total 1,855 isolates from 44 hospitals May 2016, analyzed serotypes by sequential multiplex PCR. each patient age, source clinical specimen, pattern.The most common were 11A (10.1%), followed 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), 35B (6.2%). The major invasive (12.6%), (7.8%),...
A finger-actuated microfluidic reciprocator was developed and exploited to improve the recovery rate of nucleic acid purification in a device.