A5057698092- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Force Microscopy Techniques and Applications
- Iron oxide chemistry and applications
- Lipid Membrane Structure and Behavior
- Characterization and Applications of Magnetic Nanoparticles
- Magnetic Properties and Synthesis of Ferrites
- Minerals Flotation and Separation Techniques
- Conducting polymers and applications
- Advanced biosensing and bioanalysis techniques
- Solidification and crystal growth phenomena
- Microstructure and Mechanical Properties of Steels
- Material Dynamics and Properties
- Trace Elements in Health
- Remote Sensing and Land Use
- Biochemical and Structural Characterization
- Alzheimer's disease research and treatments
- Microfluidic and Bio-sensing Technologies
- Nanoparticle-Based Drug Delivery
- Fungal Infections and Studies
- Computational Drug Discovery Methods
- Quasicrystal Structures and Properties
- Metallic Glasses and Amorphous Alloys
- Cultural Heritage Materials Analysis
National University of Science and Technology
2005-2025
National University of Science and Technology
2011-2024
The Ministry of Education and Science of the Russian Federation
2015
In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism action and design new drugs. this work, a platinized nanoelectrode placed into single cell detection ROS signal, drug-induced production then recorded. The main advantages method are short incubation time drug its high sensitivity which allows low intracellular concentrations. We have shown that our can measure response to chemotherapy...
Mechanical properties of living cells determined by cytoskeletal elements play a crucial role in wide range biological functions.
β-Amyloid aggregation on living cell surfaces is described as responsible for the neurotoxicity associated with different neurodegenerative diseases. It suggested that of β-amyloid (Aβ) peptide neuronal surface leads to various deviations its vital function due myriad pathways defined by internalization calcium ions, apoptosis promotion, reduction membrane potential, synaptic activity loss, etc. These are structural reorganizations and pathologies cytoskeleton mainly involving actin...
The biodistribution of chemotherapy compounds within tumor tissue is one the main challenges in development antineoplastic drugs, and techniques for simple, inexpensive, sensitive, selective detection various analytes tumors are great importance. In this paper we propose use platinized carbon nanoelectrodes (PtNEs) electrochemical platinum-based drugs biological models, including single cells spheroids vitro inside solid vivo. We have demonstrated quantitative direct Pt(II) breast...
Microscopic mechanisms of the crystallization from melt provide for conversion short-range order a liquid state into long-range solid crystalline and determine in much primary microstructure. The "choice" proper structure is not trivial process that ruled by thermodynamics. On other hand microscopic point view it takes time atoms to be incorporated ordered leads formation some intermediate region between disordered crystal. In paper origin properties was called "the pre-crystallization...
In connection with the emergence of new pathogenic strains Candida, search for more effective antifungal drugs becomes a challenge. Part preclinical trials such can be carried out using innovative ion-conductance microscopy (ICM) method, whose unique characteristics make it possible to study biophysical biological objects high accuracy and low invasiveness. We conducted novel synthesized thiazolidinedione’s antimicrobial (for Candida spp.) anticancer properties (on samples human prostate...
Additive manufacturing of metallic parts by Selective Laser Melting (SLM) implies high temperature gradients and small volume the melt bath. These conditions make process scales close to those available for state-of-the-art massively parallel atomistic simulations. In paper, microscopic mechanisms responsible formation primary microstructure during molten metal solidification are investigated using classical molecular dynamics (CMD). The 316L austenitic stainless steel with face centred...
Abstract Alzheimer’s disease (AD) is the most common form of dementia, a progressive neurological disorder characterized by short and long-term memory loss, including cognitive functional impairment, which refractory to current therapy. It suggested that aggregation β-amyloid (Aβ) peptide on neuronal cell surface leads various deviations its vital function due myriad pathways defined internalization calcium ions, apoptosis promotion, reduction membrane potential, synaptic activity loss etc....
Super-resolution microscopy is widely used in the development of novel antimicrobial testing vitro. In presented work, a scanning protocol was developed by method ion-conducting (SICM), which makes it possible to study microorganisms without rigid fixation and saline, obtaining an index map nanosized structures. The effect azole echinocandins drugs on morphology mechanical properties Candida parapsilosis yeast studied. findings are consistent with previously proposed drug mechanisms reports...
Five bifunctional copper chelating agents,
The morphological and mechanical properties of hydrogels with different stiffness have been assessed by SICM AFM.
Abstract This study aims to investigate the potential role of antioxidants in oxidative stress and its consequent impact on mechanical properties neuronal cells, particularly induced by amyloid‐beta (1–42) (Aβ 42 ) aggregates. A key aspect our research involved using scanning ion‐conductance microscopy (SICM) assess (Young's modulus) cells under stress. Reactive oxygen species (ROS) level was measured single‐cell electrochemical method low‐invasive Pt nanoelectrode. We investigated effects...
Studying single cells opens opportunities for understanding many biological processes and, as a consequence, plays an important role in the development of biomedicine. Scanning Ion Conductance Microscopy (SICM) and nanopipette systems analysis represent powerful tool investigating morphological, mechanical, biochemical features living with nanometer spatial resolution under near-natural conditions. Over last decades, SICM has shown great success studying manipulating cells, non-contact...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation F. N. Chukhovskii, S. V. Salikhov, A. M. Polyakov; Statistical cumulant average theory for describing the grazing-incidence small-angle X-ray scattering from rough surfaces. AIP Conf. Proc. 6 September 2012; 1476 (1): 105–108. https://doi.org/10.1063/1.4751575 Download citation file: Ris (Zotero) Reference...