A5055789401- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Dental Implant Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Dental Research and COVID-19
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Cellular Mechanics and Interactions
- Reconstructive Surgery and Microvascular Techniques
- Cytokine Signaling Pathways and Interactions
- Engineering Education and Technology
- Nanoparticle-Based Drug Delivery
- Surface Modification and Superhydrophobicity
- Magnesium Alloys: Properties and Applications
- Ultrasound and Hyperthermia Applications
- Problem and Project Based Learning
- Dental Radiography and Imaging
Wenzhou Medical University
2023-2025
Wuhan University
2014-2023
Hubei University of Technology
2021
Soochow University
2021
Ruihua Affiliated Hospital of Soochow University
2021
West Virginia University
2020
Ministry of Education of the People's Republic of China
2012
The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth factors which are expressed in a coordinated cascade events. aim this study was to create dual factor-release system that allows for time-controlled release facilitate regeneration. We fabricated core–shell SF/PCL/PVA nanofibrous mats using coaxial electrospinning layer-by-layer (LBL) techniques, where morphogenetic protein 2 (BMP2) incorporated into the core nanofibers connective factor (CTGF) attached...
Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation, differentiation chondrocytes. These properties make it suitable for the fabrication scaffolds broad range silk fibroin-based biomaterials cartilage regenerative therapy, which can heal functional without scar tissue. It be used single material making different kinds or composite other types biomaterials....
The treatment of massive bone defects is still a significant challenge for orthopedists. Here we have engineered synthetic porous AuPd alloy nanoparticles (pAuPds) as hyperthermia agent in situ regeneration through photothermal therapy (PTT). After being swallowed by cells, pAuPds produced mild localized heat (MLH) (40-43 °C) under the irradiation near-infrared laser, which can greatly accelerate cell proliferation and regeneration. Almost 97% cranial defect area (8 mm diameter) was covered...
Abstract Various materials are utilized as artificial substitutes for bone repair. In this study, a silk fibroin (SF) hydrogel reinforced by short silica nanoparticles (SiNPs)‐distributed‐silk nanofibers (SiNPs@NFs), which exhibits superior osteoinductive property, is fabricated treating defects. SF acts the base part of composite scaffold to mimic extracellular matrix (ECM), organic component native bone. The distribution SiNPs clusters within partially mimics mineral crystals ECM....
Bone tissue engineering has become one of the most effective methods for treating bone defects. In this study, an electrospun membrane containing magnesium was successfully fabricated by incorporating oxide (MgO) nanoparticles into silk fibroin and polycaprolactone (SF/PCL)-blend scaffolds. The release kinetics Mg2+ effects on scaffold morphology, cellular behavior were investigated. obtained Mg-functionalized nanofibrous scaffolds displayed controlled Mg2+, satisfactory biocompatibility...
As a non-invasive technology, photodynamic therapy (PDT) has been widely studied for tumor ablation and infection control. In recent years, nanoparticle (NP)-based PDT attracted significant interest in improving wound healing. By photodynamically tuning the temperature of wounds, NP-based may promote cell proliferation generate reactive oxygen species, thereby playing beneficial role tissue regeneration. this mini review, pioneering work enhancing healing skin, bone, cartilage is presented....
Exosomes are extracellular membranous nanovesicles that mediate local and systemic cell-to-cell communication by transporting functional molecules, such as proteins, into target cells, thereby affecting the behavior of receptor cells. originating from adipose-derived mesenchymal stem cells (ADSCs) considered a multipotent abundant therapeutic tool for tissue injury. To investigate ADSC-secreted exosomes their potential function in repair, we isolated supernatants ADSCs via...
Osteochondral scaffolds designed with bi-phasic and multi-phasic have typically struggled post-implantation delamination. To address this issue, we developed a novel integrated scaffold natural continuous interface heterogeneous bilayer structure. Through layer-by-layer wet electrospinning, two-dimensional (2D) bi-layer membranes of silk fibroin (SF) polycaprolactone (PCL) were fabricated. These then transformed into three-dimensional (3D) using CO2 gas foaming technique, followed by gelatin...
Abstract Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in site induces marrow mesenchymal (BMSCs) migration, but its mechanism remains unclear. Our previous study studies by other groups have reported the involvement of signal transducer activator transcription 3 (STAT3) pathway cell migration. However, role STAT3 hypoxia‐induced still unknown. In this study, we investigated signaling BMSCs osteogenic differentiation. isolated...
Objective: Osteochondral defect presents a big challenge for clinical treatment. This study aimed at constructing bi-layered composite chitosan/chitosan-β-tricalcium phosphate (CS/CS-β-TCP) scaffold and repairing the rat osteochondral defect. Approach: The CS/CS-β-TCP was fabricated by lyophilization, its microstructure observed scanning electron microscope. Chondrocytes bone marrow stem cells (BMSCs) were seeded into CS layer CS-β-TCP layer, respectively. Viability proliferation ability of...