A5008251719- Enzyme Structure and Function
- Biochemical and Molecular Research
- Tuberculosis Research and Epidemiology
- RNA and protein synthesis mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Cytokine Signaling Pathways and Interactions
- Microtubule and mitosis dynamics
- Protein Structure and Dynamics
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- 3D Printing in Biomedical Research
- CAR-T cell therapy research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Biochemical Analysis and Sensing Techniques
- Facial Rejuvenation and Surgery Techniques
- Biochemical effects in animals
- Synthesis of Tetrazole Derivatives
- Monoclonal and Polyclonal Antibodies Research
- Hair Growth and Disorders
- Zoonotic diseases and public health
- Mycobacterium research and diagnosis
- Vitamin C and Antioxidants Research
- Glycosylation and Glycoproteins Research
- Neuropeptides and Animal Physiology
- Vaccine Coverage and Hesitancy
King Abdulaziz University
2020-2025
University College London
2020-2023
University of Jeddah
2023
Protein filaments are used in myriads of ways to organize other molecules within cells. Some filament-forming proteins couple the hydrolysis nucleotides their polymerization cycle, thus powering movement molecules. These termed cytomotive. Only members actin and tubulin protein superfamilies known form cytomotive filaments. We examined basis cytomotivity via structural studies cycles homologs from across tree life. analyzed published data performed experiments designed disentangle functional...
New triazoloquinazoline derivatives were synthesized to explore their cytotoxic activity on various cancer cell lines, prompted by the need for effective anticancer agents. All compounds confirmed spectroscopic methods and tested in vitro inhibitory activities against hepatocellular carcinoma (HepG-2), breast (MCF-7), prostate (PC3) lines. Ten VEGFR-2. Additionally, studies investigated most active compound 6, including cycle analysis, apoptotic assessment, effect gene expression, safety...
This study aimed to develop three-dimensional (3D) baricitinib (BAB) pills using polylactic acid (PLA) by fused deposition modeling. Two strengths of BAB (2 and 4% w/v) were dissolved into the (1:1) PEG-400 individually, diluting it with a solvent blend acetone ethanol (27.8:18:2) followed soaking unprocessed 200 cm~6157.94 mg PLA filament in acetone—ethanol. FTIR spectrums 3DP1 3DP2 filaments calculated recognized drug encapsulation PLA. Herein, 3D-printed showed amorphousness infused...
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the Middle East coronavirus (MERS-CoV) are highly pathogenic human coronaviruses (CoVs). Anti-CoVs mAbs vaccines may be effective, but emergence of neutralization escape variants is inevitable. Angiotensin-converting enzyme 2 dipeptidyl peptidase 4 getaway receptors for SARS-CoV-2 MERS-CoV, respectively. Thus, we reformatted these as Fc-fusion decoy receptors. Then, tested them in parallel with anti-SARS-CoV (ab1-IgG)...
Summary Protein filaments are used in myriads of ways to organise other molecules space and time within cells. Some filament-forming proteins couple the hydrolysis nucleotides their polymerisation cycle, thus powering directed movement molecules. These termed cytomotive. Only members actin tubulin protein superfamilies known form cytomotive filaments. We sought examine basis cytomotivity via structural studies cycles homologues from across tree life. analysed published data performed new...
Background: Mpro protease, an enzyme found in coronaviruses (PDB codes: 6LU7 and 2GTB), provides a unique way to recognize potentially active substances. All of the suggested drugs shared ethanolamine/propylamine bridge, consisting two three lengths carbon atoms, treat COVID-19 patients. Because this, author chose conduct study using ascorbic acid, also known as R-5-(S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one, potent immune system booster for combating coronavirus. Objective: In...
Background: The combination of patients' unsustainable use antibiotics and doctors' inappropriate prescribing practices has resulted in challenges for disease control the community inadequate delivery healthcare services. Methods: General Public's understanding awareness AMR One Health Approach policy were evaluated through a cross-sectional study questionnaire. Results analysed statistically using SPSS software Study participants' knowledge, attitude, perspective scores predicted ordinal...
Mycobacterium tuberculosis is responsible for more than 1.6 million deaths per year. Overcoming failure from established therapies owing to multidrug resistance requires the identification of novel targets. One potential antibacterial target filamentous temperature sensitive protein Z (FtsZ), which bacterial homologue mammalian tubulin, a validated cancer target. M. FtsZ function essential, with its inhibition leading arrest cell division, elongation and eventual death. However, development...