A5046915708- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Genetics, Aging, and Longevity in Model Organisms
- Sirtuins and Resveratrol in Medicine
- Supramolecular Self-Assembly in Materials
- FOXO transcription factor regulation
- DNA and Nucleic Acid Chemistry
- Virus-based gene therapy research
- Force Microscopy Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Surface Modification and Superhydrophobicity
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Polymer Nanocomposite Synthesis and Irradiation
- thermodynamics and calorimetric analyses
Oregon Health & Science University
2018-2023
University of California, San Diego
2016-2021
La Jolla Bioengineering Institute
2019
Senescent cells accumulate in tissues over time as part of the natural ageing process and removal senescent has shown promise for alleviating many different age-related diseases mice. Cancer is an age-associated disease there are numerous mechanisms driving cellular senescence cancer that can be detrimental to recovery. Thus, it would beneficial develop a senolytic acts not only on but also prevent recurrence or progression.We used molecular modelling series rationally designed peptides...
High affinity and specificity are considered essential for reagents molecularly-targeted therapeutics, such as monoclonal antibodies. However, life's own molecular cellular machinery consists of lower affinity, highly multivalent interactions that metastable, but easily reversible or displaceable. With this inspiration, we have developed a DNA-based reagent platform uses massive avidity to achieve stable, specific recognition polyvalent targets. We previously selected these DNA reagents,...
Synthetic small-diameter vascular grafts (<6 mm) are used in the treatment of cardiovascular diseases, including coronary artery disease, but fail much more readily than similar made from autologous tissue. A promising approach to improve patency rates synthetic is promote adhesion endothelial cells luminal surface graft. In this study, we characterized chemical and topographic changes imparted on poly(vinyl alcohol) (PVA), an emerging hydrogel graft material, after exposure various reactive...
Dysregulated proteolytic activity has been observed in various human diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Thus, there is an immense need to develop simple sensitive methods monitor specific protease activities biological solutions for the detection prognosis of these In this article, we describe a fluorogenic label-free method using rationally designed β-sheet-rich nanoplatelet-forming peptide precursor intercalating dye, thioflavin T....
Background: Senescent cells accumulate in tissues over time as part of the natural aging process and removal senescent has shown promise for alleviating many different age-related diseases mice. Cancer is an age-associated disease there are numerous mechanisms driving cellular senescence cancer that can be detrimental to recovery. Thus, it would beneficial eliminate prevent recurrence or progression. Methods: We used molecular modeling develop a series rationally designed peptides mimic...