A5050242237- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Pancreatic and Hepatic Oncology Research
- Adolescent and Pediatric Healthcare
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Phagocytosis and Immune Regulation
- Liver Disease and Transplantation
- Macrophage Migration Inhibitory Factor
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Pancreatitis Pathology and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- CAR-T cell therapy research
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Drug-Induced Hepatotoxicity and Protection
- Peroxisome Proliferator-Activated Receptors
- Liver Diseases and Immunity
- Neuroinflammation and Neurodegeneration Mechanisms
- Sepsis Diagnosis and Treatment
The University of Texas Health Science Center at Houston
2021-2023
Cleveland Clinic Lerner College of Medicine
2018-2022
Cleveland Clinic
2015-2022
Michigan State University
2009-2015
University of Cartagena
2014
There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including most deadly form known as hepatitis (AH). However, mechanisms by which gut synergize with excessive alcohol intake promote injury are poorly understood. Furthermore, whether drugs selectively target microbial metabolism can improve ALD has never been tested. We used liquid chromatography tandem mass spectrometry quantify levels of microbe and host...
Abstract The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process tumorigenesis would aid in establishing targets for effective prevention therapy. Here, we interrogated differential molecular mechanisms dependent on cell origin subtype promote PDAC initiation established tumors. Transcriptomic analysis cell-of-origin–dependent epithelial gene signatures...
Pancreatic ductal adenocarcinoma (PDAC) presents a 5-year overall survival rate of 11%, despite efforts to improve clinical outcomes in the past two decades. Therapeutic resistance is hallmark this disease, due its dense and suppressive tumor microenvironment (TME). Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) promising local ablative potential immunomodulatory therapy for PDAC. In study, we performed RFA preclinical tumor-bearing KrasG12D; Trp53R172H/+; Pdx1:Cre (KPC)...
Complement plays a crucial role in microbial defense and clearance of apoptotic cells. Emerging evidence suggests complement is an important contributor to alcoholic liver disease. While component 1, Q subcomponent (C1q)-dependent activation contributes ethanol-induced injury, the alternative pathway injury unknown. Activation via classical pathways was detected hepatitis patients. Female C57BL/6J [wild type (WT)], C1q-deficient ( C1qa −/− , lacking activation), protein 4-deficient C4 lectin...
Given the lack of effective therapies and high mortality in acute alcohol-associated hepatitis (AH), it is important to develop rationally designed biomarkers for disease management. Complement, a critical component innate immune system, contributes uncontrolled inflammatory responses leading liver injury, but also involved hepatic regeneration. Here, we investigated whether panel complement proteins activation products would provide useful severity AH aid predicting 90-day mortality.
Mitophagy removes damaged mitochondria to maintain cellular homeostasis. Aryl hydrocarbon receptor (AhR) expression in the liver plays a crucial role supporting normal functions, but its impact on mitochondrial function is unclear. Here, we identified new of AhR regulation mitophagy control hepatic energy
Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In murine model of IDILI, otherwise nontoxic doses TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The depended on TVX-induced, small but significant prolongation tumor necrosis factor-<i>α</i> (TNF) appearance plasma. enhancement TNF expression by was reproduced vitro RAW 264.7 macrophages (RAW cells) stimulated with LPS. current...
Acute and chronic alcohol abuse has adverse impacts on both the innate adaptive immune response, which may result in reduced resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection promote progression of coronavirus disease 2019 (COVID-19). However, there are no large population-based data evaluating potential causal associations between consumption COVID-19.We conducted a Mendelian randomization study using from UK Biobank explore association risk SARS-CoV-2...
Background & Aims: Chronic ethanol exposure results in inflammation adipose tissue; this response is associated with activation of complement as well the development alcohol-related liver disease (ALD). Adipose communicates other organs, including liver, via release soluble mediators, such adipokines and cytokines, characterized "adipose secretome". Here we investigated role anaphaylatoxin receptors C3aR C5aR1 tissue regulation secretome murine ALD (mALD). Methods: Wild-type C57BL/6 (WT),...
Background Macrophage migration inhibitory factor ( MIF ), a pluripotent immune regulator, is an emerging mediator in alcohol‐related liver disease ALD ). associated with progression through its chemokine‐ and cytokine‐like activities. Methods Mechanistic studies into the role of ethanol (EtOH)‐induced injury were performed Mif −/− mice C57 BL /6J treated small‐molecule antagonist, 098, after Gao‐Binge (acute‐on‐chronic) EtOH feeding, feeding protocol hepatic neutrophilia induction unfolded...
Trovafloxacin (TVX) is a fluoroquinolone antibiotic known to cause idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanism underlying this toxicity remains unknown. Previously, an animal model of IDILI mice revealed that TVX synergizes with inflammatory stress from bacterial lipopolysaccharide (LPS) produce hepatotoxic interaction. required prolongation the appearance tumor necrosis factor-<i>α</i> (TNF) plasma. results presented here describe TVX/LPS coexposure RAW 264.7...
The chemokine system of ligands and receptors is implicated in the progression alcohol-associated hepatitis (AH). Finding upstream regulators could lead to novel therapies. This study involved coordinated expression chemokines livers healthy controls (HC) patients with AH 2 distinct cohorts various chronic liver diseases. Studies cultured hepatocytes tissue-specific KO were used for mechanistic insight into a potential regulator AH. Selected C-X-C members IL-8 family C-C CCL20 highly...
Increased body mass index (BMI) and metabolic abnormalities are controversial prognostic factors of lung cancer. However, the relationship between overweight/obesity phenotypes hospital readmission in patients with cancer is rarely reported.We established a retrospective cohort using United States (US) Nationwide Readmissions Database (NRD). We included adult diagnosed from January 1, 2018 to November 30, excluded combined other cancers, pregnancy, died during hospitalization, low weight,...