A5011445856- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
Saga University
2016-2025
The Japanese Society of Gastroenterological Surgery
2019-2024
Saga-Ken Medical Centre Koseikan
2019
Creative Research Enterprises (United States)
2018
Saga Medical School Hospital
2016
Kyushu Hospital
2008-2012
University of Maryland, College Park
2011
Society of Thoracic Surgeons
2011
Kyushu University
1998-2007
Society of Surgical Oncology
2007
Allergic inflammation triggered by exposure of an allergen frequently leads to the onset chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanisms underlying chronicity in allergic remain unresolved. Periostin, a recently characterized matricellular protein, interacts with several cell surface integrin molecules, providing signals for tissue development remodeling. Here we show that periostin is critical mediator amplification persistence using mouse...
Importance Evidence of implementation laparoscopic gastrectomy for locally advanced gastric cancer is currently insufficient, as the primary end point in previous prospective studies was evaluated at a median follow-up time 3 years. More robust evidence necessary to verify noninferiority gastrectomy. Objective To compare 5-year survival outcomes between laparoscopy-assisted distal (LADG) and open (ODG) with D2 lymph node dissection cancer. Design, Setting, Participants This multicenter,...
A large-scale multicenter historical cohort study was conducted to investigate the efficacy of laparoscopic gastrectomy (LG) in comparison open (OG) for locally advanced gastric cancer.LG is now practiced widely, but its applicability cancer still controversial. As oncologic outcomes randomized trials are pending, there an urgent need information that would be relevant current practice.Through a consensus meeting involving surgeons and biostatisticians, 30 preoperative variables possibly...
Patients with scirrhous gastric cancer (SGC) frequently develop peritoneal dissemination, which leads to poor prognosis. The secreted protein angiopoietin-like-4 (ANGPTL4), is induced by hypoxia, exerts diverse effects on progression. Here, we aimed determine the biological function of ANGPTL4 in SGC cells under hypoxia. levels were higher hypoxia than other types cells. Hypoxia-induced mRNA expression was regulated hypoxia-inducible factor-1α (HIF-1α). Under hypoxic conditions, monolayer...
Aim Hepatocellular carcinoma ( HCC ) is the second leading cause of cancer mortality worldwide. An excess iron in liver tissue causes oxidative stress, to hepatocellular carcinogenesis. Iron metabolism, which regulated by a complex mechanism, important for cell survival. The aim this study clarify role regulatory protein progression and patient outcome. Methods results We first investigated mRNA level metabolism‐related genes, including hepcidin, ferroportin 1 FPN ‐1) transferrin receptor...
In this retrospective review, we evaluated the advantages and disadvantages of LADG for patients heavier weight with early gastric cancer.LADG has been used to treat cancer. We others have reported less operative blood loss, pain, recovery bowel activity, restart oral intake, a shorter hospital stay compared conventional open method. There is, however, little information on obese cancer.Between January 1996 March 2002, 76 preoperatively diagnosed carcinoma underwent in our department....
Diffusion-weighted magnetic resonance imaging (DW-MRI) permits non-invasive assessment of tumor characteristics.To assess the value DW-MRI as a potential marker aggressiveness in rectal cancer by analyzing relationship between tumoral apparent diffusion coefficient (ADC) values MRI and histopathologic prognostic parameters that are not affected preoperative chemoradiation therapy.Forty patients with were assessed primary staging 3-T MRI, including DWI, before undergoing surgical therapy. In...
Mitochondrial autophagy (mitophagy) is a selective form of and critical step in excluding mitochondria damaged by stress, including hypoxia. This study aimed to determine whether the integrity mitophagy affected production mitochondrial reactive oxygen species (mtROS), hypoxia inducible factor (HIF)-1α expression aggressive characteristics GC cells under Three cell lines, 44As3, 58As9 MKN45, were investigated this study. HIF-1α was induced three lines hypoxia, with higher observed 44As3...
Abstract Background and Objectives It has been shown that the hedgehog (Hh) signaling pathway is activated in gastric cancer. To investigate viability of Hh as a therapeutic target, we analyzed activation Methods Surgically resected carcinoma specimens lymph nodes were immunohistochemically. We used percentage cancer cells with nuclear translocation Gli1 marker activation. Results Nuclear localization was higher 28 undifferentiated‐type tumors than 30 differentiated‐type tumors. Eighteen...