A5051953893- Advanced Drug Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Hydrogels: synthesis, properties, applications
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Drug Solubulity and Delivery Systems
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Pharmaceutical Economics and Policy
- Clinical Nutrition and Gastroenterology
- HER2/EGFR in Cancer Research
- Pharmaceutical studies and practices
- Medication Adherence and Compliance
- Carbohydrate Chemistry and Synthesis
- 3D Printing in Biomedical Research
- Antibiotics Pharmacokinetics and Efficacy
- Enzyme Catalysis and Immobilization
- Proteoglycans and glycosaminoglycans research
Massachusetts Institute of Technology
2022-2025
Harvard University
2024
Brigham and Women's Hospital
2024
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations easier ingest, they lack the capacity localize therapeutics with excipients nor act as controlled release devices. Here we describe drug based on in situ-forming tough (LIFT) hydrogels that bridge advantages solid and dosage forms. LIFT form directly stomach through sequential ingestion crosslinker solution calcium dithiol crosslinkers, followed by drug-containing polymer alginate four-arm...
Oral drug delivery of proteins is limited by the degradative environment gastrointestinal tract and poor absorption, requiring parenteral administration these drugs. Luminal mucus represents initial steric dynamic barrier to absorption. To overcome this barrier, we report development RoboCap, an orally ingestible, robotic capsule that locally clears layer, enhances luminal mixing, topically deposits payload in small intestine enhance RoboCap’s mucus-clearing churning movements are...
Oral drug delivery is a widely used method of administration; however, achieving localized release at specific regions the gastrointestinal (GI) tract generally accomplished by using broad environmental differences. The GI complex system with regional differences in composition, such as selective expression mucin glycoproteins different organs. Here, we identify small molecule ligands that can selectively bind to mucins localize intestine and stomach. We demonstrate up 10-fold increase...
While most oncologists know that many chemotherapies are dosed on a body surface area (BSA) basis, fewer the equations used to estimate BSA based study done over 100 years ago using data from just 9 people. Moreover, two patients with same can have factors, such as composition and genetics, which impact drug’s pharmacokinetics pharmacodynamics, resulting in worse therapeutic outcomes. To solve this problem, we developed medical device personalize dose of chemotherapy patient during an...
Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost-effective improved health outcomes. Even though fixed dose combination (FDC) drug products are the only currently available single poly-pill regimens, lack flexibility adjustment a limits their efficacy. To fill existing gap personalization simplification commonly encountered cardiovascular disease, tuberculosis, tapering corticosteroid therapy, modular titratable polypill...
ABSTRACT Tablets and capsules are a cornerstone of medicine, but these solid dosage forms can be challenging to swallow for geriatric pediatric patients. While liquid formulations easier ingest, lack the capacity localize therapeutics excipients nor act as controlled release devices. To bridge advantages forms, here we describe drug based on in situ -forming tough (LIFT) hydrogels. Drug-loaded LIFT hydrogels formed directly stomach through sequential ingestion crosslinker solution calcium...