A5101776992- Epigenetics and DNA Methylation
- Renal and related cancers
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Chalcogenide Semiconductor Thin Films
- Botanical Studies and Applications
- Periodontal Regeneration and Treatments
- RNA Research and Splicing
- Advanced Thermoelectric Materials and Devices
- Paleontology and Stratigraphy of Fossils
- Plant Pathogens and Fungal Diseases
- Genetics and Neurodevelopmental Disorders
- Geology and Paleoclimatology Research
- Evolution and Paleontology Studies
- Mesenchymal stem cell research
- Yeasts and Rust Fungi Studies
- Quantum Dots Synthesis And Properties
Capital Medical University
2025
Guangzhou Institutes of Biomedicine and Health
2017-2021
Chinese Academy of Sciences
2020-2021
Shanghai University
2021
Guangzhou Medical University
2017-2020
Institute of Earth Environment
2020
Beijing Forestry University
2016
Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutionarily conserved play critical roles in development cancer. However, their cell fate decisions early embryonic remain poorly understood. Here we report knockout of polycomb genes human stem cells causes pluripotency loss spontaneous differentiation toward a meso-endoderm fate, owing to de-repression BMP signalling. Moreover, with deletion EZH1 or EZH2 fail differentiate into ectoderm lineages. We...
Abstract The first major build-up of Antarctic glaciation occurred in two consecutive stages across the Eocene–Oligocene transition (EOT): EOT-1 cooling event at ~34.1–33.9 Ma and Oi-1 ~33.8–33.6 Ma. Detailed orbital-scale terrestrial environmental responses to these events remain poorly known. Here we present magnetic geochemical climate records from northeastern Tibetan Plateau margin that are dated precisely ~35.5 31 by combined magneto- astro-chronology. These suggest a hydroclimate...
Neurogenesis, a highly orchestrated process, entails the transition from pluripotent to neural state and involves progenitor cells (NPCs) neuronal/glial subtypes. However, precise epigenetic mechanisms underlying fate decision remain poorly understood. Here, we delete KDM6s (JMJD3 and/or UTX), H3K27me3 demethylases, in human embryonic stem (hESCs) show that their deletion does not impede NPC generation hESCs. KDM6-deficient NPCs exhibit poor proliferation failure differentiate into neurons...
The genetic control of plant architecture is a promising approach to breed desirable cultivars, particularly in ornamental flowers. In this study, the F1 population (142 seedlings) derived from Lagerstroemia fauriei (non-dwarf) × L. indica 'Pocomoke' (dwarf) was phenotyped for six traits (plant height (PH), internode length (IL), number, primary lateral branch (PLBH), secondary and number), IL PLBH were positively correlated with PH trait considered representative indexes PH. Fifty non-dwarf...
Abstract Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here this study, by employing an array of different approaches, such as gene knock-out, RNA-seq, ChIP-seq, et al., we uncover that EZH2, important PRC factor, specifies normal fate decision through repressing competing meso/endoderm program. EZH2 −/− hESCs show aberrant re-activation genes during...