A5101917851- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Multiple Sclerosis Research Studies
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Neonatal and Maternal Infections
- Electrocatalysts for Energy Conversion
- NF-κB Signaling Pathways
- Lipid Membrane Structure and Behavior
- Ultrasound and Hyperthermia Applications
- Hippo pathway signaling and YAP/TAZ
- Diabetes Management and Research
- Hemoglobinopathies and Related Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Exercise and Physiological Responses
- T-cell and B-cell Immunology
- Burn Injury Management and Outcomes
- Dermatologic Treatments and Research
- Polyomavirus and related diseases
- TGF-β signaling in diseases
- Inorganic Chemistry and Materials
Zunyi Medical University
2020-2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
Fujian Medical University
2019-2025
Union Hospital
2019-2025
Huazhong University of Science and Technology
2024
Genomics Institute of the Novartis Research Foundation
2015-2023
John Jay College of Criminal Justice
2023
Guangdong Medical College
2020
The Ohio State University Wexner Medical Center
2018
<h3>Objective</h3> To determine the sensitivity of T2*-weighted gradient-echo (T2*GRE) and inversion recovery turbo-field-echo (TFE) sequences for cortical multiple sclerosis lesions at 7 T. <h3>Design, Setting, Participants</h3> Autopsied brain tissue from individuals with was scanned 3-dimensional T2*GRE white matter–attenuated TFE Cortical visible either sequence were scored each anatomical lesion type. Imaged then processed immunohistochemical analysis, identified by labeling antibody...
MRI phase imaging in multiple sclerosis (MS) patients and autopsy tissue have demonstrated the presence of iron depositions white matter lesions. The accumulation some but not all lesions suggests a specific, potentially disease-relevant process, however; its pathophysiological significance remains unknown. Here, we explore role lesional using approaches: immunohistochemical examination autoptic MS tissue, an vitro model iron-uptake human cultured macrophages ultra-highfield highly active...
Abstract Background Diabetic wounds are one of the most common and serious complications diabetes mellitus, characterized by dysfunction wound-healing-related cells in quantity quality. Our previous studies revealed that human amniotic epithelial (hAECs) could promote diabetic wound healing paracrine action. Interestingly, numerous demonstrated exosomes derived from stem critical vehicles for cell therapy. However, whether hAECs (hAECs-Exos) mediate effects on remains unclear. This study...
Diabetic foot ulcers (DFUs) are characterized by dynamic wound microbiome, the timely and accurate identification of pathogens in clinic is required to initiate precise individualized treatment. Metagenomic next-generation sequencing (mNGS) has been a useful supplement routine culture method for etiological diagnosis DFUs. In this study, we utilized mNGS analyze same DFU samples results were compared. Forty from patients with DFUs at tertiary medical center South China collected,...
Less apoptosis and excessive growth of fibroblasts contribute to the progression hypertrophic scar formation. Cuprous oxide nanoparticles (CONPs) could have not only inhibited tumor by inducing inhibiting proliferation cells, but also promoted wound healing. The objective this study was further explore therapeutic effects CONPs on formation in vivo vitro.In vivo, a rabbit ear model established New Zealand albino rabbits. Six full-thickness circular wounds (10 mm diameter) were made each ear....
Implant-related infections (IRIs) present a significant challenge in clinical treatment because of the formation biofilms. The complex architecture biofilms not only impedes antibiotic penetration, fostering evolution multidrug resistance bacteria under minimal selective pressure but also suppresses antimicrobial activity macrophages and induces their pyroptosis large quantities. This excessive impairs collective immune function macrophages, enabling pathogens to evade system clearance...
In this review article, we explore the characteristics of RNA viruses and their potential threats to humanity. We also provide a brief overview primary contemporary techniques used for early detection such viruses. After thoroughly analyzing strengths limitations these methods, highlight importance integrating nucleic acid testing with immunological assays in virus detection. Although notable methodological differences between immune pose challenges, emerging single-molecule...
Toll-like receptor (TLR) 7 and TLR8 are endosomal sensors of the innate immune system that activated by GU-rich single stranded RNA (ssRNA). Multiple genetic functional lines evidence link chronic activation TLR7/8 to pathogenesis systemic autoimmune diseases (sAID) such as Sjögren's syndrome (SjS) lupus erythematosus (SLE). This makes targeting TLR7/8-induced inflammation with small-molecule inhibitors an attractive approach for treatment patients suffering from diseases. Here, we describe...
Sepsis is a life-threatening multi-organ dysfunction syndrome (MODS) associated with dysregulated body responses to infection and the leading cause of death in intensive care units (1)(2)(3). In 2017, total 48.9 million cases sepsis 11 sepsis-related deaths were recorded worldwide, latter accounting for approximately 20% global (4-6). Despite decades research, substantial breakthroughs specific treatments have yet be achieved. High incidence mortality rates, coupled limited non-specific...
The cancer burden continues to escalate in China. This study was designed quantify the of deaths attributable modifiable risk factors for major cancers China from 2012 2035, and provide evidence-based recommendations management. Using nationally representative data on mortality, a comparative assessment approach employed calculate temporal trend population-attributable fractions (PAFs) 15 associated with PAF decreased 64.5% (95% uncertainty interval [UI]: 46.2%-75.3%) 59.3% UI: 40.6%-71.2%)...