A5065664689- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Bariatric Surgery and Outcomes
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Cell Adhesion Molecules Research
- Liver physiology and pathology
- Bone health and osteoporosis research
- Metabolism, Diabetes, and Cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Bone health and treatments
- Bone Metabolism and Diseases
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cardiovascular Disease and Adiposity
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Fluid Dynamics and Vibration Analysis
- Dietary Effects on Health
- Cardiac Fibrosis and Remodeling
Shanghai Jiao Tong University
2024
Ruijin Hospital
2024
First Affiliated Hospital of Chengdu Medical College
2019-2024
Beijing Shijitan Hospital
2021-2023
Capital Medical University
2015-2023
Genomics Institute of the Novartis Research Foundation
2006-2023
John Jay College of Criminal Justice
2023
Southern Medical University
2023
Wuhan University of Technology
2004-2022
Jilin University
2016
The synthesis, preclinical profile, and in vivo efficacy rat xenograft models of the novel selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) described as well rational design strategy employed to overcome development deficiencies first generation ALK 4 (TAE684). Compound is currently phase 1 2 clinical trials with substantial antitumor activity being observed ALK-positive cancer patients.
NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of pathway has been associated with a number autoinflammatory disorders. To date, direct inhibitors have not described due to technical challenges targeting the oligomeric complex. Receptor interacting kinase 2 (RIPK2) intracellular serine/threonine/tyrosine kinase, key signaling partner,...
The emergence of targeted therapies for MET exon 14 (METex14) skipping mutations has significantly changed the treatment landscape NSCLC and other solid tumors. METex14 results in activating MET-HGF pathway promoting tumor cell proliferation, migration, preventing apoptosis. Type Ib inhibitors, designed to selectively target "DFG-in" conformation MET, characteristically bind ATP-binding pocket a U-shaped conformation, extending into solvent-accessible region interact strongly with residue...
Objective To investigate the clinical significance of detection bone mineral density (BMD) and turnover markers (BTM) in older women with osteoporosis, to compare their predictive power for osteoporotic fractures (OF). Methods In this retrospective study, 96 patients OF 107 osteoporosis who were hospitalized Department Orthopedics at First Affiliated Hospital Chengdu Medical College examined from October 2017 February 2019. All selected divided into either fracture group (96 cases, 47.3%) or...
Numerical computation was conducted to investigate the flow-induced sunroof buffeting noise at low Mach numbers. In order avoid stiffness problem which occurs in solving compressible fluid equations numbers, new governing were derived with assumption that there is a slight compressibility effect. The mechanisms of investigated by considering three-dimensional model cavity. Extensive wind tunnel tests verify computational scheme developed present study. results demonstrated strong pressure...
Protein kinases intrinsically translate their conformations between active and inactive states, which is key to enzymatic activities. The conformational flipping of the three-residue conservative motif, Asp-Phe-Gly (DFG), crucial for many kinases' biological functions. Obtaining a detailed demonstration DFG process its corresponding dynamical thermodynamical features could broaden our understanding conformation-activity relationship. In this study, we employed metadynamics simulation, widely...
Toll-like receptor (TLR) 7 and TLR8 are endosomal sensors of the innate immune system that activated by GU-rich single stranded RNA (ssRNA). Multiple genetic functional lines evidence link chronic activation TLR7/8 to pathogenesis systemic autoimmune diseases (sAID) such as Sjögren's syndrome (SjS) lupus erythematosus (SLE). This makes targeting TLR7/8-induced inflammation with small-molecule inhibitors an attractive approach for treatment patients suffering from diseases. Here, we describe...
To assess the correlation between body components with insulin resistance (IR) and islet beta cell function in patients newly diagnosed type 2 diabetes mellitus (T2DM) or pre-diabetes (pre-DM) to explore whether this differs males females.111 diabetic pre-diabetic were recruited cross-sectional study. 75g oral glucose tolerance test was used determine diagnosis of DM pre-DM. Homeostasis model assessment (HOMA-IR) disposition index (DI30) calculated IR function, respectively. Whole-body...
To investigate the association of bedtime with risk early-onset diabetes mellitus (DM) and islet beta cell function.138 participants treat-naïve DM were included in this study. All underwent a 75g oral glucose tolerance test. Sleep habit was obtained through standardized questionnaire. Bedtime categorized as < 22:00, 22:00-24:00, ≥ 24:00 Multivariate logistic regression multiple linear used to estimate between function, respectively.Patients had later than those late-onset DM. Individuals...
We aimed to analyze the serum vitamin D level in Chinese patients with type 2 diabetes mellitus (T2DM) and discuss its correlation nonalcoholic fatty liver disease (NAFLD).A total of 300 T2DM (92 without NAFLD 208 NAFLD) were enrolled, 25-hydroxyvitamin [25-(OH)D] levels compared between two groups. Second, fibrosis score (NFS) index (FLI) used group complicated by NAFLD, differences 25-(OH)D different degrees compared. Third, multiple regression analysis was independent predictors NAFLD.The...
The tyrosine-protein kinase Met (c-Met) is an important signaling molecule involved in cellular growth and division. dysregulation of c-Met may induce many fatal diseases, including non-small cell lung cancer, gastrointestinal cancers, hepatocellular carcinoma, etc. activation the dominant by structure dynamics functional motifs, which are regulated adenosine triphosphate (ATP) binding. inhibitors bind to ATP-binding site or allosteric pocket compete with ATP molecules alter conformation...