A5101422397- Heat shock proteins research
- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Blood disorders and treatments
- Mitochondrial Function and Pathology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mass Spectrometry Techniques and Applications
- Cardiovascular Function and Risk Factors
- Pneumocystis jirovecii pneumonia detection and treatment
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Cell Image Analysis Techniques
- Neonatal Health and Biochemistry
- Coronary Artery Anomalies
- Ion channel regulation and function
- Pneumonia and Respiratory Infections
- Cardiovascular Disease and Adiposity
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Erythrocyte Function and Pathophysiology
- Cardiovascular Effects of Exercise
- Hippo pathway signaling and YAP/TAZ
University of Cincinnati
2014-2019
University of Cincinnati Medical Center
2014-2019
Sabin Vaccine Institute
2019
Guangdong General Hospital
2016
Guangdong Academy of Medical Sciences
2016
Columbia University
2015
Significance The massive cell death, associated with a heart attack, is mainly due to disruption of mitochondrial membrane integrity upon activation the permeability transition pore. Thus, it important understand how this pore regulated prevent cardiac death. In study, we reported that hematopoietic-substrate-1 protein X-1 (HAX-1) an inhibitor and promotes survival. HAX-1 works through recruitment chaperone called Hsp90 from cyclophilin-D, major component Displacement cyclophilin-D...
Abstract The chemokine (C‐X‐C motif) receptor 4 ( CXCR 4) is expressed on native cardiomyocytes and can modulate isolated cardiomyocyte contractility. This study examines the role of in response to ischaemia‐reperfusion (I/R) injury. Isolated adult rat ventricular were subjected hypoxia/reoxygenation (H/R) simulate I/R In H/R injury, decrease expression was associated with dysfunctional energy metabolism indicated by an increased adenosine diphosphate/adenosine triphosphate (ADP/ATP) ratio....
Cardiomyocyte-specific increases in phosphorylated Hsp20 (S16D-Hsp20) to levels similar those observed human failing hearts are associated with early fibrotic remodeling and depressed left ventricular function, symptoms which progress heart failure death. The underlying mechanisms appear involve translocation of the nucleus upregulation interleukin (IL)-6, subsequently activates cardiac fibroblasts a paracrine fashion through transcription factor STAT3 signaling. Accordingly, treatment...
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, systematic pipeline for efficient identification combination treatments could bring huge biomedical benefit. In order facilitate rational design therapies, we developed comprehensive computational model that incorporates available biological knowledge and relevant experimental data on life-and-death response individual cancer cells cisplatin or combined with TNF-related apoptosis-inducing ligand (TRAIL)....
The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) hosts with impaired immune systems. Current therapies for PCP, such trimethoprim-sulfamethoxazole (TMP-SMX), suffer from significant treatment failures multitude of serious side effects. Novel therapeutic approaches (i.e. newly developed drugs or novel combinations available drugs) are needed to treat this potentially opportunistic infection. Quantitative Systems...
HCLS1 Associated Protein X-1 (HAX1) promotes cell survival through attenuation of the damaged signals from endoplasmic reticulum and mitochondria, which are known as prominent intracellular compartments for autophagic process under stress conditions. This study investigates whether autophagy can be upregulated in response to HAX1 overexpression identifies functional motif responsible induction. Autophagosome accumulation, mitochondrial membrane potential (Δψm), apoptosis were assessed HEK293...
Sarcoplasmic reticulum (SR) calcium handling is central not only in the control of heart function during excitation-contraction coupling but also mitochondrial energetics and apoptosis. Recent studies have identified anti-apoptotic protein, HS-1 associated protein X-1 (HAX-1) as a novel regulator SR cycling. Although HAX-1 has been shown to localize mitochondria various tissues, we found out that it localizes through its interaction with phospholamban (PLN) cardiac muscle. Acute or chronic...
Background: Heat shock protein 20 (Hsp20) has emerged as a novel cardioprotector against stress-induced injury. In this study, we investigated the functional significance of human Hsp20 mutation (S10F) in peri-partum cardiomyopathy. Methods and Results: We identified S10F-Hsp20 mutant with frequency 2.8% dilated cardiomyopathy patients (470 screened), while did not find any normal subjects carrying (282 screened). To determine S10F-Hsp20, transgenic mice cardiac-specific overexpression were...
Introduction: Heat shock protein 20 (Hsp20) is the only small heat that can be phosphorylated by PKA upon β-adrenergic stimulation. Interestingly, phosphorylation of Hsp20 highly elevated following I/R injury and in human heart failure. However, functional significance this vivo currently unclear. Results: Transgenic lines with cardiac overexpression constitutively (S16D) were generated we chose one 10-fold to mimic levels observed failing hearts. Longitudinal assessment function via...