A5101529561- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Blood disorders and treatments
- Histone Deacetylase Inhibitors Research
- Cardiac electrophysiology and arrhythmias
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Advanced X-ray and CT Imaging
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Nitrogen and Sulfur Effects on Brassica
- Signaling Pathways in Disease
- Sirtuins and Resveratrol in Medicine
- RNA regulation and disease
- Radiation Dose and Imaging
- Blood Pressure and Hypertension Studies
- Mass Spectrometry Techniques and Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Garlic and Onion Studies
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
Tongren Hospital
2025
Zhengzhou University
2014-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Ministry of Education of the People's Republic of China
2017-2023
First Affiliated Hospital of Kunming Medical University
2018-2023
Kunming Medical University
2018-2023
First Affiliated Hospital of Zhengzhou University
2019
Yulin University
2018
University of Cincinnati Medical Center
2008-2017
Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and repression. The up-regulated LSD1's expression has been reported several malignant tumors. In current study, we designed synthesized five series 1,2,3-triazole-dithiocarbamate hybrids screened their inhibitory activity toward LSD1. We found that some these compounds, especially compound 26, exhibited most robust inhibition Interestingly, 26...
Abnormal calcium cycling, characteristic of experimental and human heart failure, is associated with impaired sarcoplasmic reticulum uptake activity. This reflects decreases in the cAMP-pathway signaling increases type 1 phosphatase The increased protein activity partially due to dephosphorylation inactivation its inhibitor-1, promoting phospholamban inhibition calcium-pump. Indeed, cardiac-specific expression a constitutively active inhibitor-1 results selective enhancement phosphorylation...
Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several human cancers and recognized as a promising anticancer drug target. In the current study, we designed synthesized novel series of pyrimidine–thiourea hybrids evaluated their potential LSD1 inhibitory effect. One compounds, 6b, containing terminal alkyne appendage, shown most potent selective inhibitor vitro exhibited strong cytotoxicity against gastric cancer cells. Compound 6b also showed marked...
Significance The massive cell death, associated with a heart attack, is mainly due to disruption of mitochondrial membrane integrity upon activation the permeability transition pore. Thus, it important understand how this pore regulated prevent cardiac death. In study, we reported that hematopoietic-substrate-1 protein X-1 (HAX-1) an inhibitor and promotes survival. HAX-1 works through recruitment chaperone called Hsp90 from cyclophilin-D, major component Displacement cyclophilin-D...
Antioxidants provide a promising therapeutic effect for the cardiovascular disease. Luteolin, polyphenolic bioflavonoid, is known to confer cardioprotection, although underlying mechanisms, especially role of luteolin on antioxidant enzymes, such as peroxiredoxin family, remain unknown.
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Impaired sarcoplasmic reticulum (SR) Ca release has been suggested to contribute the depressed cardiac function in heart failure. The of from SR may be regulated by ryanodine receptor, triadin, junctin, calsequestrin, and a histidine-rich, Ca-binding protein (HRC). We observed that levels HRC were reduced animal models human To gain insight into physiological HRC, we infected adult rat myocytes with recombinant adenovirus contains full-length mouse cDNA. Overexpression (1.7-fold)...
This study aims to investigate serum metabolite changes in patients with early-stage (T1) lung adenocarcinoma, identify potential diagnostic biomarkers, and establish an early warning mechanism for T1 stage adenocarcinoma. The included two groups: a adenocarcinoma group healthy control group. Serum samples underwent non-targeted metabolomics analysis. Total ion chromatograms (TIC) were generated assess system stability. Chromatographic data analyzed using multivariate statistical methods,...
Human mutT homolog 1(MTH1), the oxidized dNTP pool sanitizer enzyme, has been reported to be highly expressed in various malignant tumors. However, oncogenic role of MTH1 gastric cancer remains determined. In current study, we found that was overexpressed human tissues and cells. Using an vitro inhibitor screening system, compounds available our laboratory were screened small molecules containing 5-cyano-6-phenylpyrimidine structure firstly show potently specifically inhibitory effect on...
Endometrial diseases, including endometrial polyps (EP), cancer (EC) and hyperplasia (EH), are common gynecological diseases that affect women of childbearing perimenopausal age. Clinically, biopsy or imaging methods usually used to screen diagnose these diseases; however, due the invasiveness heterogeneity tests, a noninvasive, convenient, objective accurate biomarker is needed for differential diagnosis EP, EC EH. In present study, serum samples from 326 patients with 225 healthy...
Abstract Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, ischemia-reperfusion injury been shown to limit therapeutic effects vascular recanalization. Protein HAX-1 reported as pro-survival protein that plays an important role in various disorders, particularly association with nervous system. However, mechanisms IR have yet be elucidated. So, we aimed investigate effect on microglial pyroptosis...
Esophageal cancer (EC) is an aggressive malignancy and the most common solid tumor of gastrointestinal tract all over world, with high incidence in Asia. The current study was designed to investigate anticancer efficacy mechanism that involved action a natural ent-kaurene diterpenoid, JDA-202, targeting EC.We found antioxidant protein peroxiredoxin I (Prx I) upregulated human EC tissues as well cell lines. novel compound isolated from Isodon rubescens (Labiatae), proved possess strong...
Hematopoietic-substrate-1 associated protein X-1 (HAX-1) has been reported as an anti-apoptosis that plays important role in several malignant tumors. However, the effect and mechanism of HAX-1 glioblastomas remains unknown. This study investigated glioblastoma cells explore mechanism. The results clone formation Edu proliferation assay showed slower multiplication knock-out cells. Apoptosis due to oxidative stress was increased after knocked out. Western-blot exhibited levels p21, Bax, p53...