A5017601006- Glioma Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Cancer Mechanisms and Therapy
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Advanced NMR Techniques and Applications
- Cancer Genomics and Diagnostics
- Heat Transfer and Boiling Studies
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Enzyme Structure and Function
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Video Surveillance and Tracking Methods
- Fluid Dynamics and Mixing
- Environmental and Sediment Control
- Genetic Syndromes and Imprinting
- Acute Myeloid Leukemia Research
China General Nuclear Power Corporation (China)
2009-2024
New York University
2021-2022
NYU Langone Health
2019-2022
Jingning County People's Hospital
2022
Shanghai Normal University
2022
Nanjing University
2021
Neurological Surgery
2021
University of California, San Francisco
2021
Quadriga Biosciences (United States)
2021
Bristol-Myers Squibb (United States)
2021
To examine the local actions of IGF signaling in skeletal tissue a physiological context, we have used Cre-mediated recombination to disrupt selectively mouse osteoblasts gene encoding type 1 receptor (Igf1r). Mice carrying this bone-specific mutation were normal size and weight but, comparison with siblings, demonstrated striking decrease cancellous bone volume, connectivity, trabecular number, an increase spacing. These abnormalities correlated rate mineralization osteoid that occurred...
Insulin-like growth factor I (IGF-I) is an important for bone, yet the mechanisms that mediate its anabolic activity in skeleton are poorly understood. To examine effects of locally produced IGF-I bone vivo, we targeted expression to osteoblasts transgenic mice using a human osteocalcin promoter. The transgene was expressed OC-IGF-I at high levels absence any change serum levels, or total body growth. Bone formation rate distal femur 3-week-old approximately twice controls. By 6 weeks,...
Abstract RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP kinase-mediated phosphorylation. However, the specific contribution of each kinase to RUNX2-dependent not known. Here we investigate ERK regulation RUNX2 using unique P-RUNX2-specific antibody. Both kinases stimulated Ser319 phosphorylation transcriptional activity. clear preference ERK1 versus p38α/β was found when ability these MAPKs phosphorylate activate compared. Similarly,...
In many skeletal diseases, including osteoporosis and disuse osteopenia, defective osteoblast differentiation is associated with increased marrow adipogenesis. The relative activity of two transcription factors, RUNX2 PPARγ, controls whether a mesenchymal cell will differentiate into an or adipocyte. Herein we show that the ERK/MAP kinase pathway, important mediator mechanical hormonal signals in bone, stimulates osteoblastogenesis inhibits adipogenesis via phosphorylation PPARγ. Induction...
Angiogenesis and bone formation are intimately related processes. Hypoxia during early development stabilizes hypoxia-inducible factor-1α (HIF-1α) increases angiogenic signals including vascular endothelial growth factor (VEGF). Furthermore, stabilization of HIF-1α by genetic or chemical means stimulates formation. On the other hand, deficiency Runx2, a key osteogenic transcription factor, prevents invasion VEGF expression. This study explores possibility that Runx2 interact to activate...
ABSTRACT Osteoblasts, which orchestrate the deposition of small apatite crystals through expression nucleating proteins, have been shown to also express clock genes associated with circadian signaling pathway. We hypothesized that protein-mediated bone mineralization may be linked oscillator mechanisms functioning in peripheral tissue. In this study, Per1 ex vivo neonatal murine calvaria organ cultures was monitored for 6 days using a Per1-luciferase transgene as bioluminescent indicator...
Insulin-like growth factor I (IGF-I) is an important for bone, yet the mechanisms that mediate its anabolic activity in skeleton are poorly understood. To examine effects of locally produced IGF-I bone vivo, we targeted expression to osteoblasts transgenic mice using a human osteocalcin promoter. The transgene was expressed OC-IGF-I at high levels absence any change serum levels, or total body growth. Bone formation rate distal femur 3-week-old approximately twice controls. By 6 weeks,...
ABSTRACT Cell–extracellular matrix (ECM) interactions play major roles in controlling progenitor cell fate and differentiation. The receptor tyrosine kinase, discoidin domain 2 (DDR2), is an important mediator of between cells fibrillar collagens. DDR2 signals through both ERK1/2 p38 MAP which stimulate osteoblast differentiation bone formation. Here we show that critical for skeletal development marrow to osteoblasts while suppressing adipogenesis. Smallie mice (Ddr2slie/slie), contain a...
The response of arterial smooth muscle cells to injury is governed by a complex series events. Significant among them the paracrine production peptide growth factors. To determine impact local IGF-I gene expression on vascular injury, left carotid arteries SMP8-IGF-I mice (in which selectively overexpressed in means α-actin promoter) and wild-type controls were injured mechanically with an epon resin probe. After 7 14 d, progressive increase medial area was seen both mice, but they not...
This study investigates the impact of various auxiliary cooling techniques on machinability, energy consumption, carbon emissions, and economic factors in drilling process AA7075T6 aluminium alloy using TiO2 C-reinforced composites. The employed conditions (dry, MQL, CO2, hybrid MQL+CO2), with different cutting speeds feed rates, to evaluate their effects characteristics. findings indicated that combined MQL CO2 notably enhanced by reducing forces 32% surface roughness 65% compared dry...
Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection not possible, and chemotherapy radiotherapy are currently only palliative. This study aimed to identify potential therapeutic agents using a computational pipeline perform in silico screen for novel drugs. We then tested the identified drugs against panel of patient-derived DIPG cell lines. Using systematic approach with publicly available databases gene...
Insulin-like growth factor I (IGF-I) has been postulated to function as a vasodilator. We explored the vasoactive effects of chronic elevations arterial IGF-I levels in SMP8-IGF-I mice, which is overexpressed smooth muscle (SM) by means SM alpha-actin promoter. Denuded aortas from mice generated increased force response KCl or phenylephrine and had greater sensitivity depolarization. This not due desensitization NO pathway, pretreatment with n-omega-nitro-L-arginine affected both wild-type...
Introduction The standard treatment for glioblastoma (GBM) patients is surgical tumor resection, followed by radiation and chemotherapy with temozolomide (TMZ). Unfortunately, 60% of newly diagnosed GBM express high levels the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) are TMZ-resistant, all eventually become refractory to treatment. blood-brain barrier (BBB) an obstacle delivery chemotherapeutic agents GBM, BBB-permeable that efficacious in TMZ-resistant needed. large...
In real-world applications, hydraulic pressure control performance is influenced by model uncertainties, the bandwidths of valves and pumps, deviations from linear working region. To overcome aforementioned obstacles, a novel reference governor for disturbance observer (DOB)-based load proposed in this paper dual-actuator-driven electrohydraulic cylinder. First, control-oriented was developed. On basis this, nonlinear DOB-based feedback controller, as well mid-range architecture variable...