A5021954808- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Maternal Mental Health During Pregnancy and Postpartum
- Gut microbiota and health
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Microplastics and Plastic Pollution
- Infant Development and Preterm Care
- Prenatal Substance Exposure Effects
- Effects and risks of endocrine disrupting chemicals
- Parvovirus B19 Infection Studies
- Reproductive tract infections research
- Pharmacological Effects and Toxicity Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Alcohol Consumption and Health Effects
- Opioid Use Disorder Treatment
- Pregnancy and Medication Impact
- Recycling and Waste Management Techniques
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
University of Hawaiʻi at Mānoa
2017-2025
University of Hawaii System
2017-2022
Mount Sinai Beth Israel
2018
Indiana University School of Medicine
2012-2017
Indiana University – Purdue University Indianapolis
2012-2017
Icahn School of Medicine at Mount Sinai
2009-2016
Hadassah Medical Center
2015
Cancer Treatment Centers of America
2014
Centers for Disease Control and Prevention
2009
New York University
1995-2007
Microplastics are created for commercial use, shed from textiles, or result the breakdown of larger plastic items. Recent reports have shown that microplastics accumulate in human tissues and may adverse health consequences. Currently, there no standardized environmental monitoring systems to track microplastic accumulation within tissues. Using Raman spectroscopy, we investigated temporal exposures pollution Hawai'i noted a significant increase discarded placentas over past 15 years, with...
Genomic imprinting refers to silencing of one parental allele in the zygotes gametes depending upon parent origin. Loss (LOI) is gain function from silent that can have a maximum effect doubling gene dosage. LOI may play significant role etiology intrauterine growth restriction (IUGR). Using placental tissue ten normal and seven IUGR pregnancies, we conducted systematic survey expression panel 74 "putatively" imprinted genes using quantitative RT-PCR. We found 52/74 ( approximately 70%) were...
Silencing of DEP-domain containing mTOR-interacting protein (DEPTOR), an endogenous inhibitor the mammalian target rapamycin (mTOR) pathway, increases mTOR signaling and System A/L amino acid transport activity in cultured primary human trophoblast cells. However, there is no evidence supporting regulatory role DEPTOR placental function vivo. We hypothesized that trophoblast-specific Deptor knockdown (KD) mice signaling, transport, enhances fetal growth. generated DeptorKD transgenic mice,...
AbstractLoss of imprinting (LOI) is the gain expression from silent allele an imprinted gene normally expressed only one parental copy. LOI has been associated with neurodevelopmental disorders and reproductive abnormalities. The mechanisms are varied, DNA methylation representing one. We have developed a functional transcriptional assay for that not limited to single mechanism imprinting. method employs allele-specific PCR analysis RT-PCR products containing common readout polymorphisms....
Gravida's poor periodontal health is emerging as a modifiable independent risk factor for preterm delivery and low birth weight.To test the hypothesis that oral bacteria other than pathogens are also associated with pregnancy outcomes, specific bacterial levels measured during were evaluated in relation to gestational age weight while controlling demographic, medical, dental variables. The study population consisted of 297 predominantly African- American women who pregnant first time....
<i>Objective:</i> To classify and compare articles, based on the study design, in four leading US obstetrics gynecology journals. <i>Methods:</i> One year of each journal, <i>American Journal Obstetrics Gynecology</i> (AJOG), <i>Obstetrics (O&#38;G), <i>Gynecologic Oncology</i> (GO), <i>Fertility Sterility</i> (F&#38;S), beginning May 1997, was reviewed. Supplementary issues were excluded from review. The percentage...
Abstract Background Consumption of a diet with high adherence to Mediterranean pattern (MDP) has been associated favorable gastrointestinal tract (GIT) microbiome. A healthy GIT microbiome in pregnancy, as defined by increased alpha diversity, is lower chance adverse perinatal outcomes. This study aimed evaluate the impact an MDP on microbial diversity longitudinally throughout pregnancy. Methods Adherence was scored Alternate (aMED) Diet Quality Score, after being applied validated Food...
Substance use including opioids, methamphetamines, benzodiazepines, and barbiturates during pregnancy is harmful for the pregnant person fetus. Routine screening using validated questionnaires recommended, but often biologic sampling done instead. There bias in urine drug on labor delivery units.
The human placenta is a glucocorticoid (GC)-responsive organ consisting of multiple cell types including smooth muscle cells, fibroblasts, and trophoblast that demonstrate changes in gene expression after hormone treatment. However, little known about the relative or activity GC receptor (GR) among various placental types. Normal term placentas were examined by immunohistochemistry using either GR phosphorylation site-specific antibodies are markers for activation states antibody recognizes...
Background: Elevation in prepregnancy body mass index (BMI) has been linked to a host of perinatal complications, but increases charges or costs associated with obesity during pregnancy have not quantified. Methods: To evaluate the economic impact as diagnosis on hospitalizations pregnant women, we performed descriptive, univariate, and multivariable analysis 1999 2005 Nationwide Inpatient Sample, nationally representative sample admissions US community hospitals. Results: Hospitalizations...
Introduction: Intrauterine growth restriction (IUGR) is a major pregnancy complication with significant postnatal implications. IUGR characterized by high placental oxidative stress (OS) and increased mitochondrial DNA (mtDNA) abundance that altogether alter the metabolism. Such alterations may be captured changes in expression of mitochondrial-encoded phosphorylation genes glycolysis-regulatory genes.Study design: We aimed here to determine association between all 13 protein-coding seven...
Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms several genes. We investigated whether the same gene loci confer a for gestational diabetes mellitus (GDM) women from Hawaii, and particular, Pacific Islander Filipino populations.Blood was collected 291 with GDM 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 controls; Filipinos: 162 395 Japanese: 58 142 controls). Maternal DNA used...
In utero colonization or deposition of beneficial microorganisms and their by-products likely occurs through various mechanisms, such as hematogenous spread ascension from the reproductive tract. With high-throughput sequencing techniques, identification microbial components in first-pass neonatal meconium has been achieved. While these are low-biomass often not abundant enough to culture, presence DNA signatures may promote fetal immune tolerance epigenetic regulation prior birth. The aim...
Extracellular matrix (ECM) proteins synthesized by human placental mesenchymal cells (PMCs) provide structural support for the villus. Aberrant expression of ECM PMCs has been associated with intrauterine growth restriction (IUGR). To insight into mechanisms protein regulation in stroma villus, current study, we examined interaction glucocorticoid (GC) and transforming factor-β (TGFβ) modulation cultures isolated from term placentas. Initial results obtained ELISA showed that combined...
Purpose: The purpose of this study is to evaluate the incidence maternal cell contamination (MCC) in first few milliliters amniotic fluid withdrawn during amniocentesis.Methods: A prospective observational was performed. initial 2–3 ml amniocentesis divided into direct analysis (uncultured) and cultured samples. matching buccal swab obtained for MCC testing. determined by short-tandem repeat analysis. primary outcome measurement clinically significant (MCC >5%). Secondary outcomes included...
Understanding how maternal diet affects in utero neonatal gut microbiota and epigenetic regulation may provide insight into disease origins long-term health. The impact of Mediterranean pattern adherence (MDA) on fetal microbiome was assessed 33 pregnant women. Participants completed a validated food frequency questionnaire each trimester pregnancy; the alternate (aMED) score applied. Umbilical cord blood, placental tissue, meconium were collected from offspring. DNA methylation patterns...