A5042597050- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Advanced Electron Microscopy Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Tuberculosis Research and Epidemiology
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Multiple Myeloma Research and Treatments
Cleveland Clinic Lerner College of Medicine
2023-2024
Mohammed V University
2017-2021
NUT carcinoma (NC) is an aggressive cancer with no effective treatment. About 70% of associated chromosome translocation events that lead to the formation a BRD4::NUTM1 fusion gene. Because gene unequivocally cytotoxic when ectopically expressed in cell lines, questions remain on whether can initiate NC. Here, we report first genetically engineered mouse model for recapitulates human t(15;19) mice. We demonstrated t(2;17) syntenic translocation, forming Brd4::Nutm1 gene, could induce...
The emergence of new omics approaches, such as genomic algorithms to identify tumor mutations and molecular modeling tools predict the three-dimensional structure proteins, has facilitated understanding dynamic mechanisms involved in pathogenesis low-grade gliomas including oligodendrogliomas astrocytomas.In this study, we targeted known gliomas, starting with sequencing regions encompassing exon 4 isocitrate dehydrogenase 1 (IDH1) 2 (IDH2) four exons (5-6 7-8) TP53 from 32 samples, followed...
Low-grade glioma is the most common type of primary intracranial tumor. In last 3 years, new observations molecular precursors in adults with gliomas have led to a modification histopathologic classification these brain tumors. Among biomarkers that been highlighted, we micro RNAs (miRNAs) which play crucial role regulation gene expression and long noncoding (lncRNAs) controlling various cellular metabolic pathways. our study, large-scale data on sequenced RNA miRNAs from 516 patients were...
Background: LMTK3 and AKT1 each have a role in carcinogenesis tumor progression. The analysis of single nucleotide polymorphisms could lead to more complete accurate risk estimates for colorectal cancer. Aim: We evaluated the association between (SNPs) cancer case-control study Moroccan population. Methods: Genomic DNA from 70 patients 50 healthy control subjects was extracted whole blood. Genotyping performed by direct sequencing after polymerase chain reactions 7 SNPs (AKT1rs1130214G/T,...
Tuberculosis is a contagious disease that usually attacks the lungs but sometimes other parts of body, such as kidneys, glands, and bones. It an endemic major public health problem in Morocco. transmitted through airways via inhalation microdroplets containing Mycobacterium tuberculosis We present here whole-genome shotgun sequences three multidrug-resistant M. strains isolated from
We report the nearly complete genome sequence and genetic variations of a clinical sample severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) collected from nasopharyngeal swab specimen male patient Harhoura-Rabat, Morocco. The sequence, which was obtained using Ion Torrent technology, is valuable as it carries recently described deletion (His69-Val70) substitution (Asn439Lys).
Abstract Nut carcinoma (NC) is an aggressive cancer with no effective treatment. The majority (70%) of NUT associated chromosome translocation events that lead to the formation a BRD4::NUTM1 fusion gene. However, because gene unequivocally cytotoxic when ectopically expressed in cell lines, questions remain on whether can initiate NC. Here, we report first genetically engineered mouse model (GEMM) for recapitulating human mutation. By stochastically inducing mirroring event, demonstrated...