A5109914270- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Lipoproteins and Cardiovascular Health
- Genomics and Rare Diseases
- Glycogen Storage Diseases and Myoclonus
- Genetic Syndromes and Imprinting
- Carbohydrate Chemistry and Synthesis
- Congenital heart defects research
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Acute Myocardial Infarction Research
- Intensive Care Unit Cognitive Disorders
- Prenatal Screening and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
- Infant Nutrition and Health
- Intestinal Malrotation and Obstruction Disorders
- Radiomics and Machine Learning in Medical Imaging
- Cellular Mechanics and Interactions
- Galectins and Cancer Biology
- Anesthesia and Neurotoxicity Research
- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Atrial Fibrillation Management and Outcomes
Mackay Memorial Hospital
2019-2025
University at Buffalo, State University of New York
2023-2025
Mackay Medical College
2019-2024
National Cheng Kung University
2024
Taipei Medical University-Shuang Ho Hospital
2024
Taipei Medical University
2022-2023
National Health Research Institutes
2011-2023
Taipei City Hospital
2022
Buddhist Tzu Chi Medical Foundation
2022
Taipei Tzu Chi Hospital
2022
There has been a long search for the chemical identity of acrasin, chemotactic substance responsible aggregation amoebae in development cellular slime molds. With help new, quantitative assay, it was possible to show that supernatants from bacterium Escherichia coli contained an attractant Dictyostelium discoideum, and now is known this cyclic 3', 5'-AMP. Furthermore, we have evidence AMP synthesized by related species Polysphondylium pallidum. It also D. discoideum synthesizes attractant,...
Adenosine-3′,5′-cyclic monophosphate was shown to be the compound found in Escherichia coli responsible for attraction of amoebae cellular slime mold Dictyostelium discoideum . A number other nucleotides were tested and following active: tubercidin-3′,5′-cyclic monophosphate, N 6 -2′- O -dibutyryl-adenosine-3′,5′-cyclic 5′-methylene adenosine-3′,5′-cyclic monophosphonate, guanosine-3′,5′-cyclic uridine-3′,5′-cyclic cytidine-3′,5′-cyclic inosine-3′,5′-cyclic thymidine-3′,5′-cyclic...
Hepatocellular carcinoma is one of the most common cancer types worldwide. In cases advanced-stage disease, sorafenib considered treatment choice. However, resistance to remains a major obstacle for effective clinical application. Based on integrated phosphoproteomic and The Cancer Genome Atlas (TCGA) data, we identified transcription factor, Y-box binding protein-1 (YB-1), with elevated phosphorylation Ser102 in sorafenib-resistant HuH-7R cells. Phosphoinositide-3-kinase (PI3K) protein...
Background and Clinical Significance: Mucopolysaccharidosis type VII (MPS VII), an ultrarare lysosomal storage disorder caused by β-glucuronidase deficiency, presents significant therapeutic challenges. Given its extreme rarity limited treatment experience in Asian populations, documenting long-term outcomes is crucial for advancing clinical knowledge improving patient care. Case Presentation: We report a 3-year follow-up of enzyme replacement therapy (ERT) the first Taiwanese case MPS VII....
Background/Objectives: Mucopolysaccharidosis (MPS) is a group of progressive lysosomal storage disorders affecting multiple organ systems. Although newborn screening enables early detection, comprehensive imaging assessment during pre-symptomatic stages remains poorly understood. This study analyzed skeletal radiographic and cardiac abdominal ultrasonographic findings in infants diagnosed by to establish an integrated model. Methods: retrospective examined 277 patients (15 MPS I, 113 II, 127...
Some people are more prone to experience and value nostalgia – an emotion that often reminds us of important relationships than others. In this research, we propose propensity may not only influence how remember our social ties, but also directly affect the structure network. Across three studies involving undergraduate students, online panel participants, a population-based longitudinal sample (N = 1,467), found trait-like was associated with increased motivation maintain networks, which in...
Some people are more prone to experience and value nostalgia—an emotion that often reminds us of important relationships—than others. In this research, we propose propensity may not only influence how remember our social ties, but also directly affect the structure network. Across three studies involving undergraduate students, online panel participants, a population-based longitudinal sample (N = 1,467), found trait-like nostalgia was associated with increased motivation maintain networks,...
Background: Silver-Russell Syndrome (SRS) is a genetic disorder characterized by prenatal and postnatal growth retardation. Affected individuals commonly present with low birth weight, intrauterine restriction, short stature, hemihypotrophy, characteristic facial features, body asymmetry. Methods: This study included 24 Taiwanese children SRS aged 2 years to 13 3 months who were recruited at MacKay Memorial Hospital other Taiwan hospitals between January 2013 December 2024. Functional...
Background/Objectives: Mucopolysaccharidosis (MPS) is a group of progressive lysosomal storage disorders affecting multiple organ systems. Although newborn screening enables early detection, comprehensive imaging assessment during pre-symptomatic stages remains poorly understood. This study analyzed skeletal radiographic and cardiac abdominal ultrasonographic findings in infants diagnosed by to establish an integrated model. Methods: retrospective examined 277 screen-positive cases (15 MPS...
Background: Silver-Russell syndrome (SRS) is a genetic disorder characterized by prenatal and postnatal growth retardation. Affected individuals commonly present with low birth weight, intrauterine restriction, short stature, hemihypotrophy, characteristic facial features, body asymmetry. Methods: This study includes 24 Taiwanese children SRS aged 2 years to 13 3 months who were recruited at MacKay Memorial Hospital other Taiwan hospitals between January 2013 December 2024. Functional...
People are less likely to help others when they view time as a scarce resource. Does changing people’s perception of influence their willingness help? We hypothesized that people would be more willing and allocate helping nonzero-sum resource (i.e., merely exists or can created moment-by-moment with interactions others) versus zero-sum commodity lost, taken, given away). Study 1 measured in hypothetical vignettes. Studies 2 3 manipulated the examine its effect on amount wanted spend helping....
Hunter syndrome (mucopolysaccharidosis II; MPS II) is caused by a defect of the iduronate-2-sulfatase (IDS) gene. Few studies have reported integrated mutation data Taiwanese II phenotypes. In this study, we summarized genotype and phenotype correlations confirmed patients asymptomatic infants in Taiwan. Regular polymerase chain reaction DNA sequencing were used to identify genetic abnormalities 191 cases, including 51 unrelated with 140 infants. IDS activity was analyzed individual novel...
Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases (LSDs) caused by an inherited gene defect. MPS patients can remain undetected unless the initial signs or symptoms have been identified. Newborn screening (NBS) programs for MPSs implemented in Taiwan since 2015, and more than 48.5% confirmed cases referred from these NBS programs. The purpose this study was to report current status update gold standard criteria required make confirmative diagnosis MPS, which requires...
Binding of von Willebrand factor (vWF) to platelet glycoprotein (GP) Ib-IX-V mediates activation in the early stage thrombus formation. Kistomin, a snake venom metalloproteinase (SVMP) purified from <i>Calloselasma rhodostoma</i>, has been shown inhibit vWF-induced aggregation. However, its action mechanism, structure-function relationship, and vivo antithrombotic effects are still largely unknown. In present study, cDNA encoding kistomin precursor was cloned revealed that is P-I class SVMP...
Mucopolysaccharidosis II (MPS II) is an X-linked disorder resulting from a deficiency in lysosomal enzyme iduronate-2-sulfatase (IDS), which causes the accumulation of glycosaminoglycans (GAGs) lysosomes many tissues and organs, leading to progressive cellular dysfunction. An MPS newborn screening program has been available Taiwan since 2015. The aim current study was collect analyze long-term follow-up data screen-positive subjects this program.From August 2015 April 2022, 548,624 newborns...
Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by genetic defects that result in deficiency of one specific enzyme activity, consequently impairing the stepwise degradation glycosaminoglycans (GAGs). Except for MPS II, other types have autosomal recessive inheritance which two copies an abnormal allele must be present order to develop. In this study, we status variant alleles and biochemistry results found infants suspected having I, IVA, VI. A total 324 infants, including...
The mucopolysaccharidoses (MPSs) are a group of rare lysosomal storage disorders characterized by the accumulation glycosaminoglycans (GAGs) and which eventually cause progressive damage to various tissues organs. We developed feasible MPS screening algorithm established cross-specialty collaboration platform between medical geneticists other specialists based on at-risk criteria allow for an earlier confirmative diagnosis MPS.Children (<19 years age) with clinical signs symptoms compatible...
Background: Mucopolysaccharidoses (MPSs) are lysosomal storage disorders wherein glycosaminoglycans accumulate because the enzymes that degrade them insufficient.The earliest symptoms, which main reasons for seeking consultation, otorhinolaryngological and commonly occur in MPS I, II, IV, VI.This retrospective study aimed to determine occurrence of manifestations patients Taiwan analyze prognosis surgical intervention, including its effect on symptoms.Methods: We reviewed 42 (30 males 12...