A5101954828- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- T-cell and Retrovirus Studies
- Helicobacter pylori-related gastroenterology studies
- Trypanosoma species research and implications
- Head and Neck Cancer Studies
- Cytomegalovirus and herpesvirus research
- Diabetes Treatment and Management
- Respiratory viral infections research
- Eosinophilic Disorders and Syndromes
- Medical Research and Treatments
- Galectins and Cancer Biology
- Metabolism, Diabetes, and Cancer
- Nerve injury and regeneration
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Studies
- Winter Sports Injuries and Performance
- Diabetes Management and Research
- Bone Metabolism and Diseases
- Neonatal Health and Biochemistry
- Virus-based gene therapy research
- Bacterial Infections and Vaccines
Jiangxi University of Traditional Chinese Medicine
2023-2025
Shanxi Medical University
2025
Baogang Group (China)
2023-2024
Second Hospital of Shandong University
2023
Lee University
2023
Inner Mongolia University
2021
Chang Gung Memorial Hospital
2021
Linkou Chang Gung Memorial Hospital
2021
National Vaccine and Serum Institute
2010-2020
Xuzhou Medical College
2011-2020
Abstract This study aimed to assess independent effects of EBV and cigarette smoking on nasopharyngeal carcinoma, which have never been assessed in long-term follow-up studies. A cohort 9,622 men was enrolled from 1984 1986. Blood samples collected at entry were tested for antibodies against antigens (anti-EBV) viral capsid antigen immunoglobulin DNase. The habit inquired through questionnaire interview. Newly developed carcinoma cases ascertained computerized linkage with national cancer...
An efficient and general strategy for the dispersion of multi-walled carbon nanotubes in water organic media was developed first time via combination mussel-inspired chemistry Michael addition reaction.
The inhibition of demyelination and the promotion remyelination are both considerable challenges in therapeutic process for many central nervous system (CNS) diseases. Increasing evidence has demonstrated that neuroglial activation neuroinflammation responsible myelin sheath damage during demyelinating disorders. It been revealed nonselective cation channel transient receptor potential vanilloid 4 (TRPV4) profoundly affects a variety physiological processes, including inflammation. However,...
Abstract A serological survey using antibody to EpsteinBarr virus (EBV)‐specific DNase activity as a marker for the identification of patients with nasopharyngeal carcinoma (NPC) has been carried out on healthy subjects who visited Government Employees' Clinic Center (GECC) routine health examination and individuals residing in NPC high‐risk areas (HRA) Taiwan. During 3‐year prospective study, 22,596 9,869 sera were collected from GECC HRA groups, respectively. Taking neutralization 2 or...
BACKGROUND Anecdotal reports have suggested that systemic chemotherapy with agents better cross the blood-brain barrier may result in long term disease remission some patients central nervous system (CNS) lymphoma. This treatment strategy has advantage of sparing late neurologic complications from brain irradiation. METHODS Eligible were required to 1) tissue-proven and measurable non-acquired immunodeficiency syndrome (AIDS)- related primary or metastatic CNS lymphoma; 2) normal hemogram,...
Abstract Human herpesvirus‐6 (HHV‐6) is a newly identified human pathogen. Currently clinicians rely mainly on blood lymphocyte culture and serological tests to diagnose HHV‐6 infection. The polymerase chain reaction (PCR) was carried out the plasma or sera of patients determine value PCR in diagnosis A total 30 entered study; 10 were experiencing acute infections 20 healthy served as controls. DNA detected by serum cases with infections. All controls had no their sera. time for become...
Background A case-control study was conducted to evaluate the role of adult diet on nasopharyngeal carcinoma (NPC) in Taiwan. Methods total 375 incident NPC cases and 327 controls matched sex, age, residence were recruited between July 1991 December 1994. structured questionnaire inquiring complete dietary history, socio-demographic characteristics, other potential confounding factors used personal interview. Unconditional logistic regression analysis estimate multivariate-adjusted odds...
Abstract Serum samples from 154 patients with nasopharyngeal carcinoma (NPC), 374 other cancers, 1,000 normal controls Government Employees' Clinic Center (GECC), and 3,642 individuals of various ethnic‐dialect groups living in high‐risk areas for NPC were collected the concentration antibodies to Epstein‐Barr virus (EBV)‐specific DNase activity was determined. Taking a serum sample where 1 ml will neutralize two or more units as positive, 24 low level, 446 medium than 6 high level antibody,...
The aim of this study was to further confirm that glial cell line-derived neurotrophic factor (GDNF) exerts a neuro-protective effect on dopaminergic neurons (DAs) and investigate the protective mechanism. Cadherins are calcium-dependent adhesion proteins, N-cadherins found in neurons. Our attempted ascertain whether GDNF activates PI3K/Akt signaling pathway through mediation N-cadherin confer DAs. Flow cytometry Hoechst 33258 staining results indicated apoptosis rate damaged neurocytes...
Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases (LSDs) caused by an inherited gene defect. MPS patients can remain undetected unless the initial signs or symptoms have been identified. Newborn screening (NBS) programs for MPSs implemented in Taiwan since 2015, and more than 48.5% confirmed cases referred from these NBS programs. The purpose this study was to report current status update gold standard criteria required make confirmative diagnosis MPS, which requires...
Dopamine D3 receptor (DRD3) was demonstrated to have important implications in schizophrenia, because it binds antipsychotic drugs and is abundant the limbic system of brain. Several groups attempted find an association between a serine-to-glycine polymorphism at codon 9 DRD3 gene (Ser9Gly) schizophrenia; however, results were inconsistent. We conducted case-control study Han Chinese schizophrenic patients from Taiwan, examine relationship this schizophrenia. noted no significant differences...
The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve screening test for individuals who are at high risk developing NPC. We previously demonstrated unaffected from high-risk families had elevated anti-EBV antibody levels compared to community controls. In this study, we measured using 2 different real-time PCR assays (targeting BamH1W and polymerase gene sequences, respectively) carried out independent research labs serum...
We have previously shown that high levels of antibody to Epstein-Barr virus (EBV)-specific DNase may be a useful marker for the early diagnosis nasopharyngeal carcinoma (NPC). Sera from 3,368 males in an area with risk development NPC were examined presence EBV-specific activity. Significant found 430 these sera. As result, 32 individuals attended out-patient department otolaryngology clinical examination. Among them, one individual was stage II carcinoma. This result supports value...
Mucopolysaccharidosis II (MPS II) is an X-linked disorder resulting from a deficiency in lysosomal enzyme iduronate-2-sulfatase (IDS), which causes the accumulation of glycosaminoglycans (GAGs) lysosomes many tissues and organs, leading to progressive cellular dysfunction. An MPS newborn screening program has been available Taiwan since 2015. The aim current study was collect analyze long-term follow-up data screen-positive subjects this program.From August 2015 April 2022, 548,624 newborns...