A5101799849- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced Drug Delivery Systems
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Psoriasis: Treatment and Pathogenesis
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Additive Manufacturing and 3D Printing Technologies
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Inflammatory Bowel Disease
The Ohio State University Wexner Medical Center
2025
University of Arizona
2021-2025
Shenzhen Bay Laboratory
2021-2024
Chinese Academy of Sciences
2014-2024
Institute of Zoology
2021-2024
Tiangong University
2024
Tsinghua University
2017-2023
University of Chinese Academy of Sciences
2018-2021
Shenzhen Institutes of Advanced Technology
2014-2021
Southern University of Science and Technology
2021
Butyrate is an energy source for colonocytes that formed by bacterial fermentation of dietary fiber in the colon and exerts broad anti-inflammatory activities. Although administration butyrate improves homeostasis patients ameliorates IBD (Inflammatory Bowel Disease)-related lesions symptoms, mechanisms still remain unclear. To explore impact on Treg (Regulatory T cell)/Th17 (T helper 17 cell) differentiation colitis rats.The effect expression markers related to both Tregs Th17 cells were...
SIRT1 is a member of the mammalian sirtuin family with ability to deacetylate histone and nonhistone proteins. The correlation between expression tumor metastasis in several types cancer has aroused widespread concern. This study investigated its prognostic value hepatocellular carcinoma (HCC). function hepatocarcinogenesis was further cell culture mouse models. Western blotting immunohistochemistry were used explore HCC lines primary clinical specimens. functions migration invasion line...
MicroRNAs (MiRs) are short noncoding RNAs that can regulate gene expression. It has been reported miR-21 suppresses apoptosis in activated T cells, but the molecular mechanism remains undefined. Tumor suppressor Tipe2 (or tumor necrosis factor-α-induced protein 8 (TNFAIP8)-like 2 (TNFAIP8L2)) is a newly identified anti-inflammatory of TNFAIP8 family essential for maintaining immune homeostasis. We report here direct target nuclear factor-κB and could expression coding region-dependent...
Sufficient mucosal permeability is the bottleneck problem in developing an efficient intestinal delivery system of insulin. Cell-penetrating peptide-based nanocomplexes for enhanced permeation insulin were developed this study. Penetratin, a cell-penetrating peptide was site-specifically modified with bis-β-cyclodextrin group. Insulin-loaded prepared by self-assembly using penetratin or its derivative (P-bis-CD). A stronger intermolecular interaction and higher complex stability observed...
Aim: The purpose of this study was to develop a new orally delivered nanoparticulate system improve the bioavailability salmon calcitonin (sCT). Materials & methods: Four sCT-loaded solid lipid nanoparticles (SLNs) were prepared successfully by micelle–double emulsion technique via either sole use stearic acid (SA) or combined SA and triglycerides (including tripalmitin [TP], trimyristin trilaurin). Results: Compared with other SLNs, combination TP could not only significantly colloidal...
Abstract Serum circulating micro RNA s (c‐mi s) are serving as useful biomarkers for cancer diagnosis. Here, we describe the development of a one‐step branched rolling circle amplification ( BRCA ) method to measure serum c‐mi levels early diagnosis breast cancer. Four s, 16 (c‐miR‐16), 21 (c‐miR‐21), 155 (c‐miR‐155), and 195 (c‐miR‐195) were isolated from 49 patients (stages I‐ IV 19 healthy controls, analyzed using . The c‐miR16, c‐miR21, c‐miR155, c‐miR195 higher P < 0.0001) in stage I...
3D printing is an effective technology for recreating skeletal muscle tissuein vitro. To achieve clinical injury repair, relatively large volumes of highly aligned cells are required; obtaining these still a challenge. It currently unclear how individual and their neighbouring components co-ordinate to establish anisotropic architectures in homogeneous orientations. Here, we demonstrated strategy followed by sequential culture processes engineer tissue. The effects confined on the during...
PROteolysis-TArgeting Chimeras (PROTACs) are a powerful class of drugs that selectively degrade the proteins interest (POIs) through cellular ubiquitination mechanisms. Estrogen receptor α (ERα) plays vital role in pathogenesis and treatment breast cancer. In this work, DNA-binding domain (DBD) ERα was selected as target to avoid drug resistance caused by ligand-binding (LBD) ERα. The estrogen response element (ERE), natural DNA sequence binding with DBD ERα, chosen recognized unit PROTAC....
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Macrophages play important roles in the regulation of innate and adaptive immune responses. Classically activated macrophages alternatively are two major forms have opposing functionalities. Tumor necrosis factor-α-induced protein 8-2 is expressed primarily by cells negatively regulates type 1 responses to maintain tolerance. While previous studies indicate that TIPE2 promotes M2 but inhibits M1 macrophage differentiation, underlying molecular mechanism which differentiation remains unclear....
Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery for large number of patients at advanced stage hepatocellular carcinoma (HCC). However, role PADI4 chemoresistance HCC has not been identified.MTT PI/Annexin V assay were employed examine proliferation apoptosis cell lines. The MDR1 detected by Realtime PCR. GFP tagged LC3 vector electron...
Autoimmune Th1 and Th17 responses are critical for the development of central nervous system (CNS) pathology in experimental autoimmune encephalomyelitis (EAE), an animal model human multiple sclerosis. Although macrophages play important roles responses, whether modulating macrophage gene transcription can diminish Th1- cell-induced CNS is unclear. In this study, we successfully silenced expression factor c-Rel mice with EAE (including those infiltrating CNS) using chemically modified...
Colon cancer (CC), one of the most frequently diagnosed malignancies deriving from digestive system, has greatly threatened human health and life. Fatty acid binding protein 7 (FABP7), an intracellular with tissue-specific expression pattern, been reported to be implicated in diverse types tumors. However, biological role FABP7 CC is still poorly understood. The current study aimed investigate illuminate potential molecular mechanisms. In this present study, we found that was highly...
The purpose of this study was to formulate nanoparticles with an elaborate structure for oral delivery exendin-4 using a simple preparation process. possessed mixed lipid shell and aqueous core which contained drug-loaded micelles. Formulation optimized by central composite design the validated. efficacy evaluated both in vitro vivo. drug encapsulation efficiency reached 97.7%. greatly enhanced cellular uptake transport encapsulated vitro. situ showed that could be transported across...