A5041525266- Family and Disability Support Research
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Language Development and Disorders
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Infant Development and Preterm Care
- Reading and Literacy Development
- Child and Adolescent Psychosocial and Emotional Development
- Assistive Technology in Communication and Mobility
- Behavioral and Psychological Studies
- Adolescent and Pediatric Healthcare
- Child Abuse and Trauma
- Genomic variations and chromosomal abnormalities
- Neurobiology of Language and Bilingualism
- Child Abuse and Related Trauma
- Homicide, Infanticide, and Child Abuse
- Telecommunications and Broadcasting Technologies
- Multimedia Communication and Technology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Family Support in Illness
- Text Readability and Simplification
King's College London
2015-2025
Evelina London Children's Healthcare
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2011-2024
St Thomas' Hospital
2016-2020
Guy's Hospital
2000-2011
University of Cambridge
2002-2009
Background: In early typical language development, children understand words before they are able to use them in speech. Children with autism spectrum disorders (ASD) generally show impairments both the comprehension and production of language. However, relative degree delay or impairment each these sub‐domains may also be atypical remains less well‐understood. Aims: Relative receptive expressive skills was examined within a large sample preschoolers autism. Children's abilities varied from...
Background There has been increasing interest in the potential for pre‐emptive interventions prodrome of autism, but little investigation as to their effect. Methods A two‐site, two‐arm assessor‐blinded randomised controlled trial ( RCT ) a 12‐session parent‐mediated social communication intervention delivered between 9 and 14 months age (Intervention British Autism Study Infant Siblings‐Video Interaction Promoting Positive Parenting), against no intervention. Fifty‐four infants (28...
Risk markers for later autism identified in the first year of life present plausible intervention targets during early development. We aimed to assess effect a parent-mediated infants at high risk on these markers. did two-site, two-arm assessor-blinded randomised controlled trial families with an infant familial aged 7–10 months, testing adapted Video Interaction Promote Positive Parenting (iBASIS-VIPP) versus no intervention. Families were randomly assigned or groups using permuted block...
<h3>Importance</h3> Intervention for individuals with autism spectrum disorder (ASD) typically commences after diagnosis. No trial of an intervention administered to infants before diagnosis has shown effect on diagnostic outcomes date. <h3>Objective</h3> To determine the efficacy a preemptive ASD beginning during prodromal period. <h3>Design, Setting, and Participants</h3> This 2-site, single rater–blinded randomized clinical vs usual care was conducted at 2 Australian research centers...
Paediatric speech and language therapist (SLT) roles often involve planning individualized intervention for specific children, working collaboratively with families education staff, providing advice, training coaching raising awareness. A tiered approach to service delivery is currently recommended whereby services become increasingly specialized children greater needs.To stimulate discussion regarding of SLT by examining evidence the effectiveness (1) disorders at different tiers (2) within...
Background The PACT randomised‐controlled trial evaluated a parent‐mediated communication‐focused treatment for children with autism, intended to reduce symptom severity as measured by modified Autism Diagnostic Observation Schedule‐Generic ( ADOS ‐G) algorithm score. therapy targeted parental behaviour, no direct interaction between therapist and child. While nonsignificant group differences were found on ‐G score, significant both parent child intermediate outcomes. This study aimed better...
Delays in development of early social behaviors babies with Down syndrome are likely to affect patterns interaction their caregivers. We videotaped 23 face-to-face mothers at 8 and 20 weeks age compared them typically developing infants mothers. Social behaviors, mothers' quality were rated. At weeks, significantly less communicative lively than the babies. Their did not differ but weeks. Although improved over time, qualitative differences remained.
We examined predictors of mental health difficulties and wellbeing in caregivers children with autism the Pre-school Autism Communication Trial cohort middle childhood (N = 104). Child's intellectual disability, daily living skills impairment, elevated emotional behavioural difficulties, high educational level caregiver household income below median significantly predicted caregivers' but severity, child communication family circumstances did not. Lower was by difficulties. The need to...
Autistic children can have difficulty generalising treatment effects beyond the immediate context. Paediatric Autism Communication Therapy (PACT) has been successful when delivered in clinic. Here we tested Therapy-Generalised (PACT-G) intervention combined between home and education settings for its overall effect mechanistic transmission of across contexts.In this parallel, single-blind, randomised, controlled trial, recruited autistic aged 2-11 years urban or semi-urban areas Manchester,...
Systematic data from a multidisciplinary clinical assessment of large series females with Rett syndrome (RS; n=87) is presented. Participants' ages ranged 2 years 1 month to 44 10 months. Areas assessed included oromotor skills, feeding problems, growth, breathing abnormalities, mobility, postural abnormalities and joint deformities, epilepsy, hand use stereotypies, self-care, cognitive communication skills. Many previously reported trends in the presentation RS over time were confirmed,...
Systematic data from a multidisciplinary clinical assessment of large series females with Rett syndrome (RS; n =87) is presented. Participants’ ages ranged 2 years 1 month to 44 10 months. Areas assessed included oromotor skills, feeding problems, growth, breathing abnormalities, mobility, postural abnormalities and joint deformities, epilepsy, hand use stereotypies, self‐care, cognitive communication skills. Many previously reported trends in the presentation RS over time were confirmed,...
Background There are very few mechanistic studies of the long‐term impact psychosocial interventions in childhood. The parent‐mediated Paediatric Autism Communication Therapy (PACT) RCT showed sustained effects on autistic child outcomes from pre‐school to mid‐childhood. We investigated mechanism by which PACT intervention achieved these effects. Methods Of 152 children randomised receive or treatment as usual between 2 and 5 years age, 121 (79.6%) were followed 5–6 after endpoint at a mean...
The aim of this study was to assess whether any memory impairment co-occurring with language is global, affecting both verbal and visual domains, or domain specific.Visual memory, learning, processing speed were assessed in children aged 6 years 16 11 months (mean 9 y m, SD 2 mo) current, resolved, no using the Wide Range Assessment Memory Learning (WRAML), a standardized learning test for children, Children's Test Non-Word Repetition (CNRep), phonological short-term memory. Fifty-one (38...