A5101568683- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Anomalies
- Oral and Maxillofacial Pathology
- Pediatric Urology and Nephrology Studies
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Parvovirus B19 Infection Studies
- Ultrasound Imaging and Elastography
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Ureteral procedures and complications
- Case Reports on Hematomas
- Cardiac Valve Diseases and Treatments
- Pituitary Gland Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
VA Portland Health Care System
2024
Churchill Hospital
2004-2019
University of Oxford
2006-2016
National Radio Research Agency
2008
Weatherford College
2008
Royal Marsden Hospital
1997-2006
St Bartholomew's Hospital
2000
Whittington Hospital
1993-1999
University College London
1993-1999
National Hospital for Neurology and Neurosurgery
1998
High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed evaluate the safety and feasibility of novel, extracorporeal HIFU device for treatment liver kidney tumours in Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFU™ Technology Company, China) has been used treat 30 patients according four trial protocols. Patients with...
To determine whether primary extracorporeal high-intensity focused ultrasound (HIFU) is safe, feasible and effective for managing small renal tumours.Although surgery currently remains the standard treatment localized cell carcinoma (RCC), increasing incidence of cancers has led to a shift towards nephron-sparing surgery, with associated morbidity in 20-25% cases, minimally invasive ablative therapies present an alternative management. HIFU results 'trackless' homogenous tissue ablation when...
Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pituitary, and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree penetrance, such that more than 95% patients develop clinical manifestations fifth decade, although this lower at approximately 50% age 20 yr. However, penetrance in younger group, which based on detecting hormone-secreting tumors, may be underestimate because have nonfunctioning tumors asymptomatic.The aim...
To assess the safety and feasibility of high-intensity focused ultrasound (HIFU) ablation liver tumours to determine whether post-operative MRI correlates with intra-operative imaging.31 patients were recruited into two ethically approved clinical trials (median age 64; mean BMI 26 kg m(-2)). Patients (primary or metastatic) underwent a single HIFU treatment monitored using B-mode ultrasound. Follow-up consisted radiology histology (surgical trial) alone (radiology trial). Radiological...
Cancer therapies usually depend on cross-sectional imaging for the assessment of treatment response. This study was designed to evaluate ability MRI predict zones necrosis following use high-intensity focused ultrasound (HIFU) treat liver metastases. Patients with metastases, who had been scheduled elective surgical resection their tumours, were recruited this non-randomized Phase II study. In each case, a proportion an index tumour target ablated. The response HIFU assessed after 12 days...
Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. commonly recur following surgery and radiotherapy, there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases, including epidermal growth factor (EGFR) type 1 insulin-like (IGF-1R), in chordoma biology. We report an adult female patient who presented 2003 with spinal chordoma, treated radiotherapy. She underwent further for recurrent 2008,...
Operative balloon dilatation of the aortic valve was performed in seven neonates with critical stenosis valve. The procedure followed by development severe regurgitation four patients. Necropsy three and revealed partial detachment right coronary cusp Damage to leaflet caused probably result using a diameter that too large relation ring shearing forces created wall contracting ventricle. inflated should not be larger than ring.
The aim of this study was to determine the accuracy MR imaging in revealing complex vaginal fistulas.Fifteen patients with clinical symptoms fistulas were examined imaging, using a combination T1-weighted, T2-weighted, and fast multiplanar inversion recovery sequences axial plane, along T2-weighted sagittal plane. Observers scans for fistula any associated masses or collections. findings recorded observers unaware results cystoscopy sigmoidoscopy under anesthesia. correlated examination...
A patient is reported on with a subarachnoid haemorrhage (SAH) from an aneurysm of the posterior communicating artery, who initially presented sentinel bleed into arachnoid cyst and normal magnetic resonance angiography (MRA) intracranial vasculature which led to delay in diagnosis. Although this very rare presentation relatively common condition, it important recognise importance intracystic such circumstances as well limitations MRA, diagnosis may have serious clinical consequences.
We report three cases of intra‐cardiac metastases from neuroendocrine tumours the carcinoid type. One presented in a manner identical to left atrial myxoma; one patient mass was noted during investigations for weight loss and lung mass; third, two right ventricular deposits were detected on echocardiography when with disseminated GHRH‐secreting tumour investigated dyspnoea. Although our knowledge this is only third these lesions, we believe that represents form heart disease distinct...
The aim of this study was to investigate the use time maximum enhancement (t(max)) for each voxel in contrast-enhanced MRI (CE-MRI) as a non-invasive tool determine areas necrosis following treatment liver tumours with high-intensity focused ultrasound (HIFU) and, having established utility t(max) maps, develop three-dimensional (3-D) representation display information concisely. 3-D T(1) weighted fast spoiled gradient echo images were acquired before and after administration contrast agent....
Chordoma is the most common malignant tumor of sacrum and associated with significant neurologic morbidity. Local recurrence very common, long-term prognosis poor. High-intensity focused ultrasound (HIFU) a noninvasive nonionising ablative therapy that has been successful in treating other types being evaluated as new for sacral chordoma. Contrast-enhanced magnetic resonance imaging typically used to evaluate perfusion following HIFU; however, its utility limited poorly perfused tumors....