A5021422677- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Antifungal resistance and susceptibility
- Phytochemistry Medicinal Plant Applications
- Advancements in Transdermal Drug Delivery
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial agents and applications
- Antimicrobial Peptides and Activities
- Plant Pathogens and Fungal Diseases
- Phytochemistry and Biological Activities
- Drug Solubulity and Delivery Systems
- Seaweed-derived Bioactive Compounds
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
- Ocular Surface and Contact Lens
- Pomegranate: compositions and health benefits
- Microbial Metabolites in Food Biotechnology
- Biochemical and Structural Characterization
- Bioactive Compounds and Antitumor Agents
- Insect Utilization and Effects
- Papaya Research and Applications
- Inhalation and Respiratory Drug Delivery
- Polysaccharides and Plant Cell Walls
- Chemical Synthesis and Analysis
- Ethnobotanical and Medicinal Plants Studies
Universidade Estadual Paulista (Unesp)
2013-2022
Centro Universitário de Araraquara
2020
Background: The incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, indicated therapy for control limitations. Hence, medicinal plants have emerged as an alternative in search new antifungal agents they present compounds, such essential oils, with important biological effects. Published data demonstrate pharmacological properties oil Cymbopogon nardus (L.) Rendle; these include anti-tumor, anti-nociceptive, and...
Abstract: Women often develop vaginal infections that are caused primarily by organisms of the genus Candida . The current treatments candidiasis usually involve azole-based antifungals, though fungal resistance to these compounds has become prevalent. Therefore, much attention been given molecules with antifungal properties from natural sources, such as curcumin (CUR). However, CUR poor solubility in aqueous solvents and oral bioavailability. This study attempted overcome this problem...
The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy treat diseases caused by bacteria. Infections Helicobacter pylori attracted attention because they directly related severe gastric medical conditions. Casearia sylvestris Swartz, popularly known guaçatonga, largely employed disorders in Brazilian folk medicine. This plant species has aroused much interest mainly...
Vulvovaginal candidiasis (VVC) is the most common infection caused by Candida albicans and greatly reduces quality of life women affected it. Due to ineffectiveness conventional treatments, there growing interest in research involving compounds natural origin. One such compound curcumin (CUR), which has been proven be effective against this microorganism. However, some CUR's physicochemical properties, especially its low aqueous solubility, make therapeutic application difficult. Thus,...
Abstract: The genus Astronium (Anacardiaceae) includes species, such as fraxinifolium , graveolens and urundeuva which possess anti-inflammatory, anti-ulcerogenic, healing, antimicrobial properties. Nanostructured lipid systems are able to potentiate the action of plant extracts, reducing required dose side effects improving activity. This work aims evaluate a nanostructured system that was developed strategy improve anti- Candida albicans activity hydroethanolic extracts stems leaves from...
Terminalia catappa L. (Combretaceae) is a medicinal plant listed as pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was evaluate the gastroprotective and healing effect aqueous fraction (FrAq) obtained leaves determine antiulcer mechanism action in experimental rodent models its activity Helicobacter pylori. In rodents, FrAq challenged by different necrotizing agents, such absolute ethanol ischemia–reperfusion injury. assessed effects after seven 14 days...
Herbal-loaded drug delivery nanotechnological systems have been extensively studied recently. The antimicrobial activity of medicinal plants has shown better pharmacological action when such are loaded into a system than they not loaded. Syngonanthus nitens Bong. (Rhul.) belongs to the Eriocaulaceae family and presents antiulcerogenic, antioxidant, antibacterial, antifungal activity. aim this study was evaluate (S. nitens) extract that (E) or (SE) liquid crystal precursor (S) for treatment...
Antimicrobial peptides can be used systemically, however, their susceptibility to proteases is a major obstacle in peptide-based therapeutic development. In the present study, serum stability of p-BthTX-I (KKYRYHLKPFCKK) and (p-BthTX-I)₂, disulfide-linked dimer, were analyzed by mass spectrometry analytical high-performance liquid chromatography (HPLC). activities assessed determining minimum inhibitory concentrations (MIC) using cation-adjusted Mueller-Hinton broth. Furthermore, biofilm...
Infectious diseases are among the leading global causes of death, increasing search for novel antibacterial agents. Among these, biologically active peptides an excellent research tool. Using solid-phase peptide synthesis (SPPS), this work aimed to synthesize derived from C-terminal region Bothropstoxin-I (BthTX-I) (p-BthTX-I, sequence: KKYRYHLKPFCKK), and its disulfide-linked dimeric form, obtained via air oxidation (p-BthTX-I)2. Two other were synthesized evaluate dimerization effect on...
In this study, was evaluated the chemical composition of a fraction from Syngonanthus nitens extract and its antimicrobial potential unloaded (Fr3) loaded (F9Fr3) into nanoemulsion (F9) composed cholesterol as oil phase (10%), polyoxyethylene 20-cetyl ether soy phosphatidylcholine (2:1) surfactant (20%), solution phosphate buffer (pH 7.4) plus chitosan polymer dispersion (0.25%) aqueous (70%) to use for VVC treatment. Phytochemical procedures showed that Fr3 is rich in luteolin, which...
Abstract: Vaginal infections caused by Candida krusei are a problem of extreme complexity due to the intrinsic resistance azole drugs. The species Syngonanthus nitens (Bong.) Ruhland is plant Eriocaulaceae family that has demonstrated promising antifungal activity. In phyto-formulation research, liquid crystal precursor mucoadhesive systems (LCPM) stand out as drug delivery for vaginal administration because they increase activity and overcome problems associated with plant-based medicines....
We have previously reported on the activity of different extracts from Astronium sp. against Candida albicans, with hydroethanolic extract prepared leaves A. urundeuva, an arboreal species widely distributed in arid environments South America and often used folk medicine, displaying highest vitro activity. Here we further evaluated antifungal this strains C. albicans glabrata, two most common etiological agents candidiasis. The was tested alone loaded into a nanostructured lipid system (10%...
Staphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It also dangerous pathogen that can cause serious and even lethal infections. The topical administration metronidazole via nanotechnology-based drug delivery systems, such as liquid crystalline modulate both permeation activity, decreasing its side effects increasing potent activity against bacteria. This study aimed at: (1) structurally developing characterizing systems composed chitosan...
Purpose: Vulvovaginal candidiasis (VVC) is an opportunistic fungal infection that adversely affects a woman's health, due to unpleasant symptoms, therapeutic challenges, and the emergence of resistant strains. The association natural products nanotechnology important improve antifungal potential medicinal plants. We aimed evaluate in vitro vivo anti- Candida albicans activity unloaded (EO) loaded (ME+EO) essential oil Cymbopogon nardus microemulsion (ME). Methods: chemical analysis EO was...
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract B. leaves has gastroprotective healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) water (AcoAq), obtained from characterize antiulcer effects these partitions mechanisms action medicinal plant. The on duodenal mucosa were...