A5109835463- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Drug Transport and Resistance Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- RNA and protein synthesis mechanisms
- Amoebic Infections and Treatments
- Signaling Pathways in Disease
- Biochemical and Molecular Research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and genetic disorders
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Apelin-related biomedical research
- Gallbladder and Bile Duct Disorders
Harbin Medical University
2014-2025
First Affiliated Hospital of Harbin Medical University
2014-2025
Sir Run Run Shaw Hospital
2024-2025
Zhejiang University
2024-2025
Shanxi Medical University
2025
Second Hospital of Shanxi Medical University
2025
XinHua Hospital
2015-2019
Ministry of Education of the People's Republic of China
2019
Abstract Background & aims Pyogenic liver abscesses (PLA) are space‐occupying lesions in the that produce high morbidity and mortality. The clinical characteristics prognosis of is different depending on bacterial culture results require strategies for management. aim this study was to investigate prognostic factors patients with PLA. Methods Clinical features, laboratory tests etiology PLA between 2006 2011 2012 2017 a single hospital were retrospectively reviewed. incidence mortality...
Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission involved in aldosterone-induced podocyte apoptosis. However, it not clear whether p53-induced critical for hypertensive Angiotensin II (AngII)-induced cardiomyocyte In this study, we inhibition of the protein Drp1 (dynamin-related 1) by Mdivi-1 prevented and remodeling SHRs. vitro treatment cultured neonatal rat cardiomyocytes...
Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro vivo. However, recent phase II trials that single agent arsenic was poorly hepatocellular carcinoma (HCC), which might be due to resistance. Mutation detection of p53 gene resistant HCC cell lines performed. The therapeutic effects Nutlin-3 on were evaluated A series experiments including MTT, apoptosis assays, co-Immunoprecipitation, siRNA transfection, lentiviral...
BackgroundHepatocellular carcinoma (HCC) is a highly fatal malignant cancer worldwide. Elucidating the underlying molecular mechanism of HCC progression critical for identification new therapeutic targets HCC. This study aimed to determine role Non-SMC condensin II complex subunit G2 (NCAPG2) in proliferation and metastasis.MethodsWe detected NCAPG2 expression tissues using immunohistochemistry, western blotting real-time PCR. The effects on cell metastasis were evaluated both vitro vivo....
Abstract Background ATP binding cassette subfamily A member 8 (ABCA8) belongs to the (ABC) transporter superfamily. ABCA8 is a transmembrane responsible for transport of organics, such as cholesterol, and drug efflux. Some members ABC subfamily, ABCA1, may inhibit cancer development. However, mechanism in process activation still ambiguous. Methods The expression human hepatocellular carcinoma (HCC) tissues cell lines was examined using qPCR, immunoblotting, immunohistochemical staining....
Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting enhanced myeloid cell leukemia 1 (Mcl-1) expression resistance to apoptosis. FTY720, a new immunosuppressant, derived from ISP-1, has been studied for its putative anti-cancer properties. This study aimed elucidate the mechanism by which FTY720 mediates antitumor effects (CC) cells.
Abstract Background Hyperoside (quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and Crataegus genera that reportedly exhibits an array of anti-inflammatory, antioxidant, antitumor properties such it has been used to treat various diseases. Whether can serve as effective treatment for chronic myeloid leukemia (CML) cells, however, yet be established. The present study was thus devised assess therapeutic effects hyperoside on CML cells...
Abstract Cystatin SN, a specific cysteine protease inhibitor, is thought to be involved in various malignant tumors. Therefore, we evaluated the role of cystatin SN hepatocellular carcinoma (HCC). Notably, was elevated tumorous samples and cells. Moreover, overexpression correlated with tumor diameter TNM stage. Cox multivariate analysis displayed that an independent prognosis indicator high level associated dismal prognosis. enhancement facilitated proliferation, migratory, invasive...
Vascular calcification (VC) is a major adverse cardiovascular event in chronic kidney disease (CKD) patients. N6-methyladenosine (m6A) modification vital for many biological processes, but its function and possible molecular mechanisms VC are poorly understood. This study aimed to clarify the of N6-adenosine-methyltransferase-like 3 (METTL3) VC. The results bioinformatic analysis showed that METTL3 expression was significantly upregulated calcified VSMCs. finding corroborated by...
Introduction The FANCI gene, an essential element of the Fanconi anemia pathway, has been associated with a variety cancer types. This investigation seeks to clarify expression profiles, prognostic relevance, and diagnostic capabilities across multiple malignancies, along its links immune cell infiltration, genetic alterations, protein-protein interactions, functional roles. Methods By utilizing data from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases, we conducted...
As a main rate-limiting subunit of the 2-oxoglutarate dehydrogenase multienzyme complex, oxoglutarate like (OGDHL) is involved in tricarboxylic acid cycle, and frequently downregulated human carcinoma suppresses tumor growth. However, little known about role OGDHL cancer, especially pancreatic cancer. Our goal to study underlying mechanism define novel signaling pathway controlled by modulating cancer progression.The expression functional analysis OGDHL, miR-214, TWIST1 tissues, cell lines,...
Abstract Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel–Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis organ- cell-specific way. In this study, human samples were collected from hepatitis C-, alcoholic-, cholestatic-associated fibrotic healthy individuals. Two mouse models established: bile duct ligation carbon tetrachloride injection. We constructed adenovirus vectors to overexpress VHL, normoxia-active lentiviral silence...
Vascular calcification is a complication that frequently encountered in patients affected by atherosclerosis, diabetes, and chronic kidney disease (CKD), characterized the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). At present, there remains pressing lack any effective therapies can treat this condition. The sodium-glucose transporter 2 (SGLT2) inhibitor dapagliflozin (DAPA) has shown beneficial effects cardiovascular disease. role context calcification, however,...
Abstract BackgroundDysregulation of RNA binding protein (RBP) expression has been reported in various malignant tumors, and it is related to the occurrence development cancer. However, role RBPs colon cancer remains unclear.MethodsWe downloaded sequencing data from The Cancer Genome Atlas (TCGA) database, determined differently expressed between normal tissues. Then, through a series bioinformatics analysis, we systematically studied prognostic value these RBPs.ResultA total 490 different...