A5035701625- Ocular Oncology and Treatments
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Voice and Speech Disorders
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Cutaneous Melanoma Detection and Management
- DNA and Nucleic Acid Chemistry
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Mast cells and histamine
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Head and Neck Anomalies
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
Second Hospital of Shanxi Medical University
2024-2025
Shanxi Medical University
2024-2025
Second Military Medical University
1997-2025
Changhai Hospital
1997-2025
Dongguan University of Technology
2025
Sanofi (United States)
2025
Shanghai University of Traditional Chinese Medicine
2024
Seventh People's Hospital of Shanghai
2014-2024
Yangzhou University
2024
Peking University First Hospital
2003-2024
The proximal 5'-flanking region of the human platelet-derived growth factor A (PDGF-A) promoter contains one nuclease hypersensitive element (NHE) that is critical for PDGF-A gene transcription. On basis circular dichroism (CD) and electrophoretic mobility shift assay (EMSA), we have shown guanine-rich (G-rich) strand DNA in this can form stable intramolecular parallel G-quadruplexes under physiological conditions. Taq polymerase stop has G-rich NHE two major G-quadruplex structures, which...
Abstract Interleukin (IL)-1–mediated inflammation is proposed to contribute the development and progression of some cancers. IL-1 family member proteins are known be expressed constitutively in many melanoma tumor cells, we hypothesize that these support molecular pathways facilitate growth. To investigate expression IL-1α IL-1β patients, their association with disease progression, immunohistochemical staining was carried out on tissues from 170 patients including benign nevi, primary...
Human papillomaviruses (HPVs) play a major role in development of cervical cancer, and HPV oncoproteins are being targeted by immunotherapies. Although these treatments show promising results the clinic, many patients do not benefit or durability is limited. In addition to antigens, neoantigens derived from somatic mutations may also generate an effective immune response, represent additional distinct immunotherapy strategy against this other HPV-associated cancers. To explore landscape...
Hepatocellular carcinoma (HCC), the most common aggressive malignancy of liver, is third leading cause cancer death across world. Laminin gamma 1 (Lamc1), encodes laminin-γ1, an extracellular matrix protein involved in various progresses such as tumor cell proliferation and metabolism. In present study, high expression Lamc1 PKM2 was observed tissues HCC patients. vitro, down-regulation inhibited cells by promoting death, reduced glucose consumption lactate production, accompanied a decrease...
To understand the mechanisms controlling platelet-derived growth factor receptor β (PDGFR-β) expression in malignancies, we have cloned and characterized first functional promoter of human PDGFR-β gene, which has been confirmed by luciferase reporter gene assays. The transcription initiation sites were mapped primer extension. Promoter deletion experiments demonstrate that proximal, highly GC-rich region (positions −165 to −139) is crucial for basal activity. This sensitive S1 nuclease...
Abstract Melanoma is molecularly and structurally heterogeneous, with some tumor cells existing under hypoxic conditions. Our cell growth assays showed that controlled conditions, BRAF(V600E) melanoma rapidly became resistant to vemurafenib. By employing both a three-dimensional (3D) spheroid model two-dimensional (2D) culture system hypoxia in vivo, we identified upregulation of HGF/MET signaling as major mechanism associated vemurafenib resistance compared 2D standard tissue ambient air....
To date, no systemic therapy, including immunotherapy, exists to improve clinical outcomes in metastatic uveal melanoma (UM) patients. understand the role of immune infiltrates genesis, metastasis, and response treatment for UM, we systematically characterized profiles UM primary tumors, as well samples from patients treated with immunotherapies. Relevant markers (CD3, CD8, FoxP3, CD68, PD-1, PD-L1) were analyzed by immunohistochemistry on 27 31 tumors 47 UM. Immune gene expression profiling...
The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with reputable cutaneous (CM) patients. To characterize the mechanisms responsible for resistance UM, we performed immune profiling tumors from 10 metastatic UM patients and CM by immunohistochemistry (IHC). Although there is no difference infiltrating CD8+ T cells between CM, a significant decrease programmed death-1 (PD-1)-positive lymphocytes was observed lower levels of death ligand-1 (PD-L1) metastases...
We previously showed that inducible nitric oxide synthase (iNOS) protein expression in melanoma tumor cells is associated with poor patient prognosis. Here, we analyzed the association between iNOS and oncogenic PI3K-AKT pathway. TCGA data show phospho-Akt Ser473 were significantly only subset of tumors genetically intact PTEN. Employing a stage III TMA, presence shorter survival PTEN expression. These findings led to our hypothesis product, (NO), suppresses function stimulates PI3K-Akt...
Abstract Background Hyperoside (quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and Crataegus genera that reportedly exhibits an array of anti-inflammatory, antioxidant, antitumor properties such it has been used to treat various diseases. Whether can serve as effective treatment for chronic myeloid leukemia (CML) cells, however, yet be established. The present study was thus devised assess therapeutic effects hyperoside on CML cells...
The sensitivity of cancer cells to anticancer drugs is a crucial factor for developing effective treatments. However, it still challenging precisely predict the effectiveness therapeutics in humans within complex genomic and molecular context. We developed an interface which allows user rapidly explore drug gene expression associations. Predictions how various genes affect activity are available all set based on data from cell lines different origin Cancer Cell Line Encyclopedia Genomics...
Vascular calcification (VC) is a major adverse cardiovascular event in chronic kidney disease (CKD) patients. N6-methyladenosine (m6A) modification vital for many biological processes, but its function and possible molecular mechanisms VC are poorly understood. This study aimed to clarify the of N6-adenosine-methyltransferase-like 3 (METTL3) VC. The results bioinformatic analysis showed that METTL3 expression was significantly upregulated calcified VSMCs. finding corroborated by...
To investigate the feasibility of an endoscopic-assisted postauricular-groove approach parotidectomy and to evaluate advantages limitations such approach.A total 72 patients with parotid gland tumors underwent a procedure between January 2014 2016. Of aforementioned patients, 15 were treated by (group I), whereas remaining 57 Blair "S" incision II).Difference in visual analogue scale score for aesthetic outcome (0 vs 3) median intraoperative blood loss (30 50 mL) was statistically...
Basilar vascular smooth muscle cells (BASMCs) hyperplasia is a prominent feature of cerebrovascular remodeling and stroke during the development hypertension. Tanshinone IIA (Tan) has been reported to exhibit protective effect against pathological features Previous studies have shown that phosphoinostitide-3 kinase (PI3K)/3′-phosphoinostitide dependent (PDK1)/AKT pathway involved in regulation proliferation various cell types. Therefore, there may be crosstalk between Tan antihypertension...
Vascular calcification is a complication that frequently encountered in patients affected by atherosclerosis, diabetes, and chronic kidney disease (CKD), characterized the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). At present, there remains pressing lack any effective therapies can treat this condition. The sodium-glucose transporter 2 (SGLT2) inhibitor dapagliflozin (DAPA) has shown beneficial effects cardiovascular disease. role context calcification, however,...