A5052180972- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Advanced Neuroimaging Techniques and Applications
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Glycogen Storage Diseases and Myoclonus
- Neurogenesis and neuroplasticity mechanisms
Northwestern University
2016-2023
Duke University Hospital
2016
Duke University
2016
Duke Medical Center
2016
Within the basal ganglia circuit, external globus pallidus (GPe) is critically involved in motor control. Aside from Foxp2 + neurons and ChAT that have been established as unique neuron types, there little consensus on classification of GPe neurons. Properties remaining types are poorly defined. In this study, we leverage new mouse lines, viral tools, molecular markers to better define subtypes. We found Sox6 represents a novel, defining marker for Lhx6 lack expression were devoid both...
The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in activity of GPe neurons during movement and their alterations Parkinson's disease (PD) argue that important motor control. Parvalbumin-positive (PV + ) Npas1 are two principal neuron classes GPe. distinct electrophysiological properties axonal projection patterns these serve different roles regulating output. However, causal relationship between remains to be established. Here, by using...
We have previously established that PV + neurons and Npas1 are distinct neuron classes in the external globus pallidus (GPe): they different topographical, electrophysiological, circuit, functional properties. Aside from Foxp2 neurons, which a unique subclass within class, we lack driver lines effectively capture other GPe subclasses. In this study, examined utility of Kcng4-Cre, Npr3-Cre, Npy2r-Cre mouse (both males females) for delineation subtypes. By using these novel lines, provided...
The prevailing circuit model predicts that hyperactivity of the striatopallidal pathway and subsequently increased inhibition external globus pallidus (GPe) neurons lead to hypokinetic symptoms Parkinson's disease (PD). It is believed due inactivity dopamine receptors on somatodendritic membrane neurons, but exact cellular underpinnings remain unclear. In this study, we show mouse GPe astrocytes critically control ambient glutamate level, which in turn gates transmission via activation...
The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway projection neurons (iSPNs), direct-pathway (dSPNs) innervate external globus pallidus (GPe). However, functions latter were not known. In this study, we interrogated organization principles striatopallidal projections and their roles full-body movement mice (both males females). contrast canonical motor-promoting response dSPNs...
Abstract We have previously established that PV + neurons and Npas1 are distinct neuron classes in the GPe— they different topographical, electrophysiological, circuit, functional properties. Aside from Foxp2 neurons, which a unique subclass within class, we lack driver lines effectively capture other GPe subclasses. In this study, examined utility of Kcng4-Cre, Npr3-Cre, Npy2r-Cre mouse (both males females) for delineation subtypes. By using these novel lines, provided most exhaustive...
Abstract The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway projection neurons (iSPNs), direct-pathway (dSPNs) innervate external globus pallidus (GPe). However, functions latter were not known. In this study, we interrogated organization principles striatopallidal projections and their roles full-body movement mice (both males females). contrast canonical motor-promoting...
Abstract The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in activity of GPe neurons during movement and their alterations Parkinson’s disease (PD) argue that important motor control. PV + Npas1 are two principal neuron classes GPe. distinct electrophysiological properties axonal projection patterns these serve different roles regulating output. However, causal relationship between remains to be established. Here, by using optogenetic...
The globus pallidus (GPe) of the basal ganglia has been underappreciated for decades due to poor understanding its cells and circuits. advent molecular tools sparked a resurgence in interest GPe. Here, we review recent flurry publications that unveiled complexity landscape cellular composition within These discoveries have revealed GPe neurons display number circuit features do not conform traditional views ganglia. Consistent with broad interconnectivity across brain, emerging evidence...