A5029456413- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Natural Antidiabetic Agents Studies
- Flavonoids in Medical Research
- Head and Neck Cancer Studies
- Metabolism, Diabetes, and Cancer
- Radiation Effects and Dosimetry
- Musculoskeletal pain and rehabilitation
- Nigella sativa pharmacological applications
- Phytochemicals and Antioxidant Activities
- Pancreatic function and diabetes
- Pharmacological Effects and Toxicity Studies
- Advanced X-ray and CT Imaging
- Digital Radiography and Breast Imaging
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Diabetes Management and Research
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Advanced Optical Sensing Technologies
- Healthcare cost, quality, practices
- Infrared Target Detection Methodologies
Johns Hopkins Medicine
2013-2024
Johns Hopkins University
2013-2024
Chang Gung Memorial Hospital
1997-2024
Health Sciences Centre
2022-2023
Sunnybrook Health Science Centre
2022-2023
Johns Hopkins Hospital
2019-2023
United States Department of Defense
2023
International Paper (United States)
2023
Novem (Netherlands)
2023
Stanford University
2007-2019
Chlorogenic acid (CGA) has been shown to delay intestinal glucose absorption and inhibit gluconeogenesis. Our aim was investigate the role of CGA in regulation transport skeletal muscle isolated from db/db mice L6 cells. Oral tolerance test performed on treated with soleus for 2-deoxyglucose study. 2DG also examined myotubes or without inhibitors such as wortmannin compound c. AMPK knocked down AMPKα1/2 siRNA study its effect CGA-stimulated transport. GLUT 4 translocation, phosphorylation...
Due to narrow therapeutic window of cancer agents and the development resistance against these agents, there is a need discover novel treat breast cancer. The antitumor activities thymoquinone (TQ), compound isolated from Nigella sativa oil, were investigated in carcinoma vitro vivo. Cell responses after TQ treatment assessed by using different assays including MTT assay, annexin V-propidium iodide staining, Mitosox staining Western blot. effect was studied tumor xenograft mouse model,...
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator poor prognosis in patients breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against cancer metastasis. In this study, we examined the effect thymoquinone (TQ), derived from seeds Nigella sativa, on regulation cells. TQ was inhibit MDA-MB-231 triple negative (TNBC) cells a dose- time-dependent...
Abstract BACKGROUND: The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated definitive chemoradiotherapy by either intensity‐modulated radiation therapy (IMRT) or conventional radiotherapy (CRT). METHODS: Forty‐six received from January 1993 August 2009 included. Forty‐five 5‐fluorouracil mitomycin C (n = 39) cisplatin 6). Seventeen (37%) CRT and 29 (63%) IMRT. median dose 54 Gy both groups. Median follow‐up 26 months...
Breast cancer is currently the leading cause of cancer-related deaths among women globally. Notably, medicinal plant extracts may be a potential source for treatments breast cancer. Vernonia amygdalina (VA) woody shrub reported to have not only diverse therapeutic effects but also anti-cancer properties. However, current research about mechanisms VA has been limited. This study aimed investigate action that underlie its in human cell lines (MCF-7 and MDA-MB-231 cells). Results from MTT assay...
Abstract BACKGROUND: The current study was performed to compare the clinical outcomes and toxicity in patients treated with postoperative chemoradiotherapy for gastric cancer using intensity‐modulated radiotherapy (IMRT) versus 3‐dimensional conformal (3D CRT). METHODS: Fifty‐seven or gastroesophageal junction were postoperatively: 26 3D CRT 31 IMRT. Concurrent chemotherapy capecitabine (n = 31), 5‐fluorouracil (5‐FU) 25), none 1). median radiation dose 45 Gy. Dose volume histogram...
Oxidative stress is the root cause of diabetic macro- and microvascular complications. Biochemical epidemiological studies indicate that current treatments for diabetes do not reduce risks developing complications, suggesting their inability to alleviate levels oxidative stress. This study in streptozotocin (STZ)-induced rats was carried out investigate effect combining antidiabetic drug, metformin, with an ethanolic extract Scutellaria baicalensis, a plant whose known its radical scavenging...
Purpose: The dosimetric leaf gap (DLG) in the Varian Eclipse treatment planning system is determined during commissioning and used to model effect of rounded leaf‐end multileaf collimator (MLC). This parameter attempts physical difference between radiation light field account for inherent leakage tips. With increased use single fraction high dose treatments requiring larger monitor units comes an enhanced concern accuracy calculations, as it accounts much patient dose. study serves verify...
Abstract Background Hyperglycemia‐induced superoxide production in the mitochondria is known to be primary cause of diabetic micro‐ and macro‐vascular complications mitochondrial membranal damage. This study streptozotocin‐induced Wistar rats investigated anti‐hyperglycemic membrane protection effects baicalin, a flavonoid for its radical scavenging activity. Methods The following oral treatments were given 30 days: (1) metformin 500 mg/kg, (2) baicalin 120 (3) mg/kg & with...
This study was designed to examine the feasibility of utilizing transabdominal ultrasound for real‐time monitoring target motion during a radiotherapy fraction. A clinical Acuson 128/XP scanner used image various stationary and moving phantoms while an Elekta SL25 linear accelerator treatment machine operating. The transducer positioned from outer edge field at all times. Images were acquired videotape analyzed using in‐house tracking algorithms determine effect on quality displacement...
This study investigated the antioxidant and antidiabetic effects of baicalin, as well its in combination with drug metformin. Three groups streptozotocin-induced diabetic rats were given following treatments for 30 days: (1) 500 mg/kg metformin; (2) 120 baicalin; (3) metformin + baicalin. In addition, vehicle-treated nondiabetic controls used experiment. The treated baicalin had significantly elevated (p < 0.05) hepatic activities superoxide dismutase, catalase, glutathione peroxidase...
The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and practice medical physics. AAPM has more than 8000 members principal organization physicists US. will periodically define new guidelines for physics help science improve quality service patients throughout Existing be reviewed purpose revision or renewal, as appropriate, on their fifth anniversary sooner. Each guideline represents...
This study investigated the effects of Rehmannia glutinosa individually as well in combination with oral hypoglycemic agent, metformin streptozotocin (STZ)-induced diabetic Wistar rats. R. ethanolic extract was prepared and constituents were characterized using fractionation by column chromatography, followed high performance liquid chromatography-mass spectrometry. STZ (65 mg/kg) injected intraperitoneally to induce diabetes The rats divided into following groups (each n = 6) received...
The Varian's new digital linear accelerator (LINAC), TrueBeam™ STx, is equipped with a high dose rate flattening filter free (FFF) mode (6 MV and 10 MV), definition multileaf collimator (2.5 mm leaf width), as well onboard imaging capabilities. A series of end-to-end phantom tests were performed, TrueBeam-based image guided radiation therapy (IGRT), to determine the geometric accuracy image-guided setup delivery process for all beam modalities delivered using intensity modulated (IMRT)...
Limited data evaluate intensity-modulated radiotherapy (IMRT) for cancers of the hypopharynx and larynx. We report clinical outcomes failure patterns these patients.Between September 2001 December 2007, 42 patients with squamous cell carcinoma (SCC) (n = 23) larynx 19) underwent IMRT, 11 postoperatively 31 definitively. Thirty-six received systemic therapy. Median follow-up was 30 months among surviving patients.Three local failures occurred within high-dose region 3 in regional nodes. Seven...
To develop and implement an automated plan check (APC) tool using a Six Sigma methodology with the aim of improving safety efficiency in external beam radiotherapy.The define-measure-analyze-improve-control (DMAIC) framework was used by measuring defects stemming from treatment planning that were reported to departmental incidence learning system (ILS). The common error pathways observed data combined our physics list, AAPM TG-275 identified items. Prioritized risk priority number (RPN)...
The chloroform and hexane fractions their sub-fractions of Polygonum bistorta (Polygonaceae) were evaluated for cytotoxic activity against P338 (Murine lymphocytic leukaemia), HepG2 (Hepatocellular carcinoma), J82 (Bladder transitional HL60 (Human MCF7 breast cancer) LL2 (Lewis lung carcinoma) cancer cell lines in culture. Both the a few showed moderate to very good P388, lines. active non-active further investigated chemical constituents. A total nine compounds, viz....